DOI: 10.1242/jcs.110.3.295. Centrosome-microtubule nucleation

10.1242/jcs.110.3.295

Crossref journal-article

The Company of Biologists

Journal of Cell Science (237)

Abstract

ABSTRACT In many cell types the formation of microtubules from tubulin subunits is initiated at defined nucleation sites at the centrosome. Thesse sites contain the conserved γ-tubulin which is in association with additional not very well characterised proteins, identified as components of a γ-tubulin ring complex from Xenopus egg extracts or from suppressor screens in the yeast Saccharomyces cerevisiae. In this review we discuss two recently proposed models of how the γ-tubulin complex assists in the assembly of tubulin to form microtubules. These models propose different roles for γ-tubulin and the other proteins in the complex in tubulin assembly. While the structure and composition of a microtubule nucleation site is becoming clearer, it is still unknown how the cell-cycle dependent regulation of microtubule nucleation sites is achieved and whether they disassemble after microtubule formation in order to allow microtubule fluxes towards the centrosome which have been observed in mitotic cells.

Bibliography

Pereira, G., & Schiebel, E. (1997). Centrosome-microtubule nucleation. Journal of Cell Science, 110(3), 295â300.

Authors 2

Gislene Pereira (first)
Elmar Schiebel (additional)

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Dates

Type	When
Created	4 years, 4 months ago (April 25, 2021, 12:49 p.m.)
Deposited	1 year, 7 months ago (Jan. 3, 2024, 7:04 p.m.)
Indexed	1 year, 5 months ago (March 28, 2024, 10:30 p.m.)
Issued	28 years, 6 months ago (Feb. 1, 1997)
Published	28 years, 6 months ago (Feb. 1, 1997)
Published Online	28 years, 6 months ago (Feb. 1, 1997)
Published Print	28 years, 6 months ago (Feb. 1, 1997)

Funders 0

None

BibTeX

@article{Pereira_1997, title={Centrosome-microtubule nucleation}, volume={110}, ISSN={1477-9137}, url={http://dx.doi.org/10.1242/jcs.110.3.295}, DOI={10.1242/jcs.110.3.295}, number={3}, journal={Journal of Cell Science}, publisher={The Company of Biologists}, author={Pereira, Gislene and Schiebel, Elmar}, year={1997}, month=feb, pages={295–300} }

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  "URL": "http://dx.doi.org/10.1242/jcs.110.3.295",
  "relation": {},
  "ISSN": [
    "0021-9533",
    "1477-9137"
  ],
  "subject": [],
  "published": {
    "date-parts": [
      [
        1997,
        2,
        1
      ]
    ]
  }
}