DOI: 10.1242/jcs.072421. An RNA-zipcode-independent mechanism that localizes<i>Dia1</i>mRNA to the perinuclear ER through interactions between Dia1 nascent peptide and Rho

An RNA-zipcode-independent mechanism that localizesDia1mRNA to the perinuclear ER through interactions between Dia1 nascent peptide and Rho–GTP

10.1242/jcs.072421

Crossref journal-article

The Company of Biologists

Journal of Cell Science (237)

Abstract

Signal-peptide-mediated ER localization of mRNAs encoding for membrane and secreted proteins, and RNA-zipcode-mediated intracellular targeting of mRNAs encoding for cytosolic proteins are two well-known mechanisms for mRNA localization. Here, we report a previously unidentified mechanism by which mRNA encoding for Dia1, a cytosolic protein without the signal peptide, is localized to the perinuclear ER in an RNA-zipcode-independent manner in fibroblasts. Dia1 mRNA localization is also independent of the actin and microtubule cytoskeleton but requires translation and the association of Dia1 nascent peptide with the ribosome–mRNA complex. Sequence mapping suggests that interactions of the GTPase binding domain of Dia1 peptide with active Rho are important for Dia1 mRNA localization. This mechanism can override the β-actin RNA zipcode and redirect β-actin mRNA to the perinuclear region, providing a new way to manipulate intracellular mRNA localization.

Bibliography

Liao, G., Ma, X., & Liu, G. (2011). An RNA-zipcode-independent mechanism that localizesDia1mRNA to the perinuclear ER through interactions between Dia1 nascent peptide and RhoâGTP. Journal of Cell Science, 124(4), 589â599.

Authors 3

Guoning Liao (first)
Xinghong Ma (additional)
Gang Liu (additional)

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Dates

Type	When
Created	14 years, 7 months ago (Jan. 25, 2011, 9:06 p.m.)
Deposited	1 year, 4 months ago (April 3, 2024, 8:48 a.m.)
Indexed	4 months, 3 weeks ago (April 9, 2025, 12:49 a.m.)
Issued	14 years, 6 months ago (Feb. 15, 2011)
Published	14 years, 6 months ago (Feb. 15, 2011)
Published Print	14 years, 6 months ago (Feb. 15, 2011)

Funders 0

None

BibTeX

@article{Liao_2011, title={An RNA-zipcode-independent mechanism that localizesDia1mRNA to the perinuclear ER through interactions between Dia1 nascent peptide and Rho–GTP}, volume={124}, ISSN={0021-9533}, url={http://dx.doi.org/10.1242/jcs.072421}, DOI={10.1242/jcs.072421}, number={4}, journal={Journal of Cell Science}, publisher={The Company of Biologists}, author={Liao, Guoning and Ma, Xinghong and Liu, Gang}, year={2011}, month=feb, pages={589–599} }

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  "abstract": "<jats:p>Signal-peptide-mediated ER localization of mRNAs encoding for membrane and secreted proteins, and RNA-zipcode-mediated intracellular targeting of mRNAs encoding for cytosolic proteins are two well-known mechanisms for mRNA localization. Here, we report a previously unidentified mechanism by which mRNA encoding for Dia1, a cytosolic protein without the signal peptide, is localized to the perinuclear ER in an RNA-zipcode-independent manner in fibroblasts. Dia1 mRNA localization is also independent of the actin and microtubule cytoskeleton but requires translation and the association of Dia1 nascent peptide with the ribosome\u2013mRNA complex. Sequence mapping suggests that interactions of the GTPase binding domain of Dia1 peptide with active Rho are important for Dia1 mRNA localization. This mechanism can override the \u03b2-actin RNA zipcode and redirect \u03b2-actin mRNA to the perinuclear region, providing a new way to manipulate intracellular mRNA localization.</jats:p>",
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