Leading the way: directional sensing through phosphatidylinositol 3-kinase and other signaling pathways
10.1242/jcs.00703
Crossref journal-article
The Company of Biologists
Journal of Cell Science (237)
Abstract

Chemoattractant-responsive cells are able to translate a shallow extracellular chemical gradient into a steep intracellular gradient resulting in the localization of F-actin assembly at the front and an actomyosin network at the rear that moves the cell forward. Recent evidence suggests that one of the first asymmetric cellular responses is the localized accumulation of PtdIns(3,4,5)P3, the product of class I phosphoinositide 3-kinase (PI3K) at the site of the new leading edge. The strong accumulation of PtdIns(3,4,5)P3 results from the localized activation of PI3K and also from feedback loops that amplify PtdIns(3,4,5)P3 synthesis at the front and control its degradation at the side and back of cells. These different pathways are temporally and spatially regulated and integrate with other signaling pathways during directional sensing and chemotaxis.

Bibliography

Merlot, S., & Firtel, R. A. (2003). Leading the way: directional sensing through phosphatidylinositol 3-kinase and other signaling pathways. Journal of Cell Science, 116(17), 3471–3478.

Authors 2
  1. Sylvain Merlot (first)
  2. Richard A. Firtel (additional)
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Dates
Type When
Created 22 years, 1 month ago (July 31, 2003, 11:25 p.m.)
Deposited 4 years, 2 months ago (June 8, 2021, 9:44 p.m.)
Indexed 2 months ago (July 3, 2025, 10:32 a.m.)
Issued 22 years ago (Sept. 1, 2003)
Published 22 years ago (Sept. 1, 2003)
Published Print 22 years ago (Sept. 1, 2003)
Funders 0

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@article{Merlot_2003, title={Leading the way: directional sensing through phosphatidylinositol 3-kinase and other signaling pathways}, volume={116}, ISSN={0021-9533}, url={http://dx.doi.org/10.1242/jcs.00703}, DOI={10.1242/jcs.00703}, number={17}, journal={Journal of Cell Science}, publisher={The Company of Biologists}, author={Merlot, Sylvain and Firtel, Richard A.}, year={2003}, month=sep, pages={3471–3478} }