DOI: 10.1242/dev.129.6.1339. Zeste maintains repression of<i>Ubx</i>transgenes: support for a new model of Polycomb repression

Zeste maintains repression ofUbxtransgenes: support for a new model of Polycomb repression

10.1242/dev.129.6.1339

Crossref journal-article

The Company of Biologists

Development (237)

Abstract

During late embryogenesis, the expression domains of homeotic genes are maintained by two groups of ubiquitously expressed regulators: the Polycomb repressors and the Trithorax activators. It is not known how the activities of the two maintenance systems are initially targeted to the correct genes. Zeste and GAGA are sequence-specific DNA-binding proteins previously shown to be Trithorax group activators of the homeotic gene Ultrabithorax (Ubx). We demonstrate that Zeste and GAGA DNA-binding sites at the proximal promoter are also required to maintain, but not to initiate, repression of Ubx. Furthermore, the repression mediated by Zeste DNA-binding site is abolished in zeste null embryos. These data imply that Zeste and probably GAGA mediate Polycomb repression. We present a model in which the dual transcriptional activities of Zeste and GAGA are an essential component of the mechanism that chooses which maintenance system is to be targeted to a given promoter.

Bibliography

Hur, M.-W., Laney, J. D., Jeon, S.-H., Ali, J., & Biggin, M. D. (2002). Zeste maintains repression ofUbxtransgenes: support for a new model of Polycomb repression. Development, 129(6), 1339â1343.

Authors 5

Man-Wook Hur (first)
Jeffrey D. Laney (additional)
Sang-Hack Jeon (additional)
Janann Ali (additional)
Mark D. Biggin (additional)

References 31 Referenced 46

Dates

Type	When
Created	4 years, 4 months ago (April 26, 2021, 1:03 a.m.)
Deposited	2 years, 8 months ago (Dec. 25, 2022, 6:59 a.m.)
Indexed	1 year, 2 months ago (June 9, 2024, 12:52 p.m.)
Issued	23 years, 5 months ago (March 15, 2002)
Published	23 years, 5 months ago (March 15, 2002)
Published Print	23 years, 5 months ago (March 15, 2002)

Funders 0

None

BibTeX

@article{Hur_2002, title={Zeste maintains repression ofUbxtransgenes: support for a new model of Polycomb repression}, volume={129}, ISSN={0950-1991}, url={http://dx.doi.org/10.1242/dev.129.6.1339}, DOI={10.1242/dev.129.6.1339}, number={6}, journal={Development}, publisher={The Company of Biologists}, author={Hur, Man-Wook and Laney, Jeffrey D. and Jeon, Sang-Hack and Ali, Janann and Biggin, Mark D.}, year={2002}, month=mar, pages={1339–1343} }

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  "abstract": "<jats:p>During late embryogenesis, the expression domains of homeotic genes are maintained by two groups of ubiquitously expressed regulators: the Polycomb repressors and the Trithorax activators. It is not known how the activities of the two maintenance systems are initially targeted to the correct genes. Zeste and GAGA are sequence-specific DNA-binding proteins previously shown to be Trithorax group activators of the homeotic gene Ultrabithorax (Ubx). We demonstrate that Zeste and GAGA DNA-binding sites at the proximal promoter are also required to maintain, but not to initiate, repression of Ubx. Furthermore, the repression mediated by Zeste DNA-binding site is abolished in zeste null embryos. These data imply that Zeste and probably GAGA mediate Polycomb repression. We present a model in which the dual transcriptional activities of Zeste and GAGA are an essential component of the mechanism that chooses which maintenance system is to be targeted to a given promoter.</jats:p>",
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