DOI: 10.1242/dev.128.4.603. <i>Drosophila</i> homologues of the transcriptional coactivation complex subunits TRAP240 and TRAP230 are required for identical processes in eye-antennal disc development

Drosophila homologues of the transcriptional coactivation complex subunits TRAP240 and TRAP230 are required for identical processes in eye-antennal disc development

10.1242/dev.128.4.603

Crossref journal-article

The Company of Biologists

Development (237)

Abstract

ABSTRACT We have identified mutations in two genes, blind spot and kohtalo, that encode Drosophila homologues of human TRAP240 and TRAP230, components of a large transcriptional coactivation complex homologous to the yeast Mediator complex. Loss of either blind spot or kohtalo has identical effects on the development of the eye-antennal disc. Eye disc cells mutant for either gene can express decapentaplegic and atonal in response to Hedgehog signaling, but they maintain inappropriate expression of these genes and fail to differentiate further. Mutant cells in the antennal disc lose expression of Distal-less and misexpress eyeless, suggesting a partial transformation towards the eye fate. blind spot and kohtalo are not required for cell proliferation or survival, and their absence cannot be rescued by activation of the Hedgehog or Notch signaling pathways. These novel and specific phenotypes suggest that TRAP240 and TRAP230 act in concert to mediate an unknown developmental signal or a combination of signals.

Bibliography

Treisman, J. E. (2001). Drosophila homologues of the transcriptional coactivation complex subunits TRAP240 and TRAP230 are required for identical processes in eye-antennal disc development. Development, 128(4), 603â615.

Authors 1

Jessica E. Treisman (first)

References 107 Referenced 99

10.1016/S0092-8674(00)80292-5 / Cell / Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor by Aza-Blanc (1997)
10.1101/gad.10.24.3183 / Genes Dev / Segmentation and specification of the Drosophila mesoderm by Azpiazu (1996)
10.1016/S0960-9822(02)70715-X / Curr. Biol / Evolution of proneural atonal expression during distinct regulatory phases in the developing Drosophila eye by Baker (1996)
10.1016/S0960-9822(06)00056-X / Curr. Biol / Proneural function of neurogenic genes in the developing Drosophila eye by Baker (1997)
10.1016/S0092-8674(00)80837-5 / Cell / act up controls actin polymerization to alter cell shape and restrict Hedgehog signaling in the Drosophila eye disc by Benlali (2000)
10.1242/dev.111.3.657 / Development / An extensive 3′ cis-regulatory region directs the imaginal disc expression of decapentaplegic, a member of the TGF-β family in Drosophila by Blackman (1991)
10.1016/S0092-8674(00)80799-0 / Cell / Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4 by Bohni (1999)
10.1242/dev.124.23.4819 / Development / The Drosophila eyes absent gene directs ectopic eye formation in a pathway conserved between flies and vertebrates by Bonini (1997)
10.1016/0092-8674(93)90115-7 / Cell / The eyes absent gene: genetic control of cell survival and differentiation in the developing Drosophila eye by Bonini (1993)
10.1006/dbio.1998.8888 / Dev. Biol / Mutual regulation of decapentaplegic and hedgehog during the initiation of differentiation in the Drosophila retina by Borod (1998)
{'key': '2023090514444749000_DEVELOP_128_4_603C11', 'first-page': '2906', 'volume': '14', 'author': 'Boube', 'year': '2000', 'journal-title': 'Drosophila homologs of transcriptional mediator complex subunits are required for adult cell and segment identity specification. Genes Dev'} / Drosophila homologs of transcriptional mediator complex subunits are required for adult cell and segment identity specification. Genes Dev by Boube (2000)
10.1038/20466 / Nature / Mammalian Srb/Mediator complex is targeted by adenovirus E1A protein by Boyer (1999)
10.1242/dev.128.1.1 / Development / Broad-complex, but not Ecdysone receptor, is required for progression of the morphogenetic furrow in the Drosophila eye by Brennan (2001)
10.1016/0092-8674(95)90291-0 / Cell / Hairy and emc negatively regulate morphogenetic furrow progression in the Drosophila eye by Brown (1995)
10.1242/dev.113.4.1245 / Development / hairy genefunction in the Drosophila eye: normal expression is dispensable but ectopic expression alters cell fates by Brown (1991)
10.1006/dbio.1996.0267 / Dev. Biol / Hedgehog-dependent patterning in the Drosophila eye can occur in the absence of dpp signaling by Burke (1996)
{'key': '2023090514444749000_DEVELOP_128_4_603C17', 'first-page': '1099', 'volume': '3', 'author': 'Cagan', 'year': '1989', 'journal-title': 'Notch is required for successive cell decisions in the developingDrosophila retina. Genes Dev'} / Notch is required for successive cell decisions in the developingDrosophila retina. Genes Dev by Cagan (1989)
10.1038/33706 / Nature / Control of antennal versus leg development in Drosophila by Casares (1998)
10.1242/dev.127.9.1921 / Development / The Iroquois homeobox genes function as dorsal selectors in the Drosophila head by Cavodeassi (2000)
10.1242/dev.124.2.559 / Development / Role of decapentaplegic in initiation and progression of the morphogenetic furrow in the developing Drosophila retina by Chanut (1997)
10.1016/S0092-8674(00)80481-X / Cell / Dachshund and eyes absent proteins form a complex and function synergistically to induce ectopic eye development in Drosophila by Chen (1997)
10.1242/dev.126.16.3607 / Development / Mutants of cubitus interruptus that are independent of PKA regulation are independent of hedgehog signaling by Chen (1999)
10.1016/0896-6273(94)90308-5 / Neuron / The Drosophila sine oculis locus encodes a homeodomain-containing protein required for the development of the entire visual system by Cheyette (1994)
10.1038/24394 / Nature / Fringe is essential for mirror symmetry and morphogenesis in the Drosophila eye by Cho (1998)
10.1016/S0092-8674(00)00124-0 / Cell / Novel signaling from the peripodial membrane is essential for eye disc patterning in Drosophila by Cho (2000)
10.1093/emboj/18.24.7029 / EMBO J / Osa associates with the Brahma chromatin remodeling complex and promotes the activation of some target genes by Collins (1999)
10.1128/MCB.19.2.1159 / Mol. Cell. Biol / The trithorax group gene moira encodes a brahma-associated putative chromatin-remodeling factor in Drosophila melanogaster by Crosby (1999)
10.1242/dev.127.6.1325 / Development / Morphogenetic furrow initiation and progression during eye development in Drosophila: the roles of decapentaplegic, hedgehog and eyes absent by Curtiss (2000)
10.1016/S1097-2765(00)80457-8 / Mol. Cell / twin of eyeless, a second Pax-6 gene of Drosophila, acts upstream of eyeless in the control of eye development by Czerny (1999)
10.1006/dbio.1995.1251 / Dev. Biol / A nuclear GFP that marks nuclei in living Drosophila embryos; maternal supply overcomes a delay in the appearance of zygotic fluorescence by Davis (1995)
10.1038/372175a0 / Nature / Cell interaction between compartments establishes the proximal-distal axis of Drosophila legs by Diaz-Benjumea (1994)
10.1101/gad.10.4.421 / Genes Dev / Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation by Doherty (1996)
10.1038/24402 / Nature / A dorsal/ventral boundary established by Notch controls growth and polarity in the Drosophila eye by Dominguez (1998)
10.1242/dev.126.11.2345 / Development / Dual role for hedgehog in the regulation of the proneural gene atonal during ommatidia development by Dominguez (1999)
10.1101/gad.11.23.3254 / Genes Dev / Hedgehog directly controls initiation and propagation of retinal differentiation in the Drosophila eye by Dominguez (1997)
10.1016/S0960-9822(98)70441-5 / Curr. Biol / Multiple functions of the EGF receptor in Drosophila eye development by Dominguez (1998)
10.1242/dev.127.2.209 / Development / Coexpression of the homeobox genes Distal-less and homothorax determines Drosophila antennal identity by Dong (2000)
10.1242/dev.125.12.2263 / Development / Identifying loci required for follicular patterning using directed mosaics by Duffy (1998)
10.1073/pnas.93.16.8329 / Proc. Natl. Acad. Sci. USA / Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex by Fondell (1996)
10.1016/S0092-8674(00)81385-9 / Cell / Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye by Freeman (1996)
10.1242/dev.126.24.5795 / Development / Progression of the morphogenetic furrow in the Drosophila eye: the roles of Hedgehog, Decapentaplegic and the Raf pathway by Greenwood (1999)
10.1016/S1097-2765(00)80178-1 / Mol. Cell / A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation by Gu (1999)
10.1242/dev.125.12.2181 / Development / Eyeless initiates the expression of both sine oculis and eyes absent during Drosophila compound eye development by Halder (1998)
10.1126/science.7892602 / Science / Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila by Halder (1995)
10.1242/dev.125.18.3741 / Development / decapentaplegic and wingless are regulated by eyes absent and eyegone and interact to direct the pattern of retinal differentiation in the eye disc by Hazelett (1998)
10.1038/373709a0 / Nature / Growth and differentiation in the Drosophila eye coordinated by hedgehog by Heberlein (1995)
10.1016/0092-8674(93)90535-X / Cell / The TGFβ homolog dpp and the segment polarity gene hedgehog are required for propagation of a morphogenetic wave in the Drosophila retina by Heberlein (1993)
10.1093/emboj/18.19.5380 / EMBO J / Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins by Hittelman (1999)
10.1016/S1097-2765(00)80463-3 / Mol. Cell / Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators by Ito (1999)
10.1016/S1097-2765(00)80247-6 / Mol. Cell / Involvement of the TRAP220 component of the TRAP/SMCC coactivator complex in embryonic development and thyroid hormone action by Ito (2000)
10.1016/S0092-8674(00)80657-1 / Cell / gigas, a Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle by Ito (1999)
10.1016/0092-8674(93)90358-W / Cell / atonal is a proneural gene that directs chordotonal organ formation in the Drosophila peripheral nervous system by Jarman (1993)
10.1038/369398a0 / Nature / atonal is the proneural gene for Drosophila photoreceptors by Jarman (1994)
10.1242/dev.121.7.2019 / Development / Role of the proneural gene, atonal, in formation of Drosophila chordotonal organs and photoreceptors by Jarman (1995)
10.1073/pnas.95.15.8538 / Proc. Natl. Acad. Sci. USA / Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways by Jiang (1998)
10.1073/pnas.89.5.1919 / Proc. Natl. Acad. Sci. USA / Altering the insertional specificity of a Drosophila transposable element by Kassis (1992)
10.1073/pnas.85.21.8136 / Proc. Natl. Acad. Sci. USA / Dosage-dependent modifiers of Polycomb and Antennapedia mutations in Drosophila by Kennison (1988)
10.1016/0092-8674(94)90221-6 / Cell / A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II by Kim (1994)
10.1101/gad.13.18.2339 / Genes Dev / ATP-dependent remodeling and acetylation as regulators of chromatin fluidity by Kingston (1999)
10.1242/dev.125.19.3875 / Development / Dissecting the roles of the Drosophila EGF receptor in eye development and MAP kinase activation by Kumar (1998)
10.1073/pnas.040556497 / Proc. Natl. Acad. Sci. USA / Notch signaling and the determination of appendage identity by Kurata (2000)
10.1073/pnas.96.26.14990 / Proc. Natl. Acad. Sci. USA / Caenorhabditis elegans mediator complexes are required for developmental-specific transcriptional activation by Kwon (1999)
10.1038/40563 / Nature / Proximal-distal axis formation in the Drosophila leg by Lecuit (1997)
10.1006/dbio.1998.9121 / Dev. Biol / Several levels of EGF receptor signaling during photoreceptor specification in wild-type, Ellipse, and null mutant Drosophila by Lesokhin (1999)
10.1016/0092-8674(93)90536-Y / Cell / The segment polarity gene hedgehog is required for progression of the morphogenetic furrow in the developing Drosophila eye by Ma (1993)
10.1242/dev.121.8.2279 / Development / wingless and patched are negative regulators of the morphogenetic furrow and can affect tissue polarity in the developing Drosophila compound eye by Ma (1995)
10.1016/S1097-2765(00)80254-3 / Mol. Cell / The USA-derived transcriptional coactivator PC2 is a submodule of TRAP/SMCC and acts synergistically with other PCs by Malik (2000)
10.1016/S0968-0004(00)01596-6 / Trends Biochem. Sci / Transcriptional regulation through mediator-like coactivators in yeast and metazoan cells by Malik (2000)
10.1242/dev.120.12.3473 / Development / dachsund encodes a nuclear protein required for normal eye and leg development in Drosophila by Mardon (1994)
10.1242/dev.127.5.1007 / Development / pannier acts upstream of wingless to direct dorsal eye disc development in Drosophila by Maurel-Zaffran (2000)
10.1101/gad.4.11.1848 / Genes Dev / Isolation and expression of scabrous, a gene regulating neurogenesis in Drosophila by Mlodzik (1990)
{'key': '2023090514444749000_DEVELOP_128_4_603C72', 'first-page': '211', 'volume': '42', 'author': 'Morata', 'year': '1975', 'journal-title': 'Minutes: mutants autonomously affecting cell division rate in Drosophila. Dev. Biol'} / Minutes: mutants autonomously affecting cell division rate in Drosophila. Dev. Biol by Morata (1975)
10.1038/255614a0 / Nature / Control of compartment development by the engrailed gene in Drosophila by Morata (1975)
10.1016/0925-4773(95)00397-J / Mech. Dev / The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways by Motzny (1995)
10.1038/19789 / Nature / Composite co-activator ARC mediates chromatin-directed transcriptional activation by Naar (1999)
10.1242/dev.127.4.851 / Development / Analysis of Drosophila photoreceptor axon guidance in eye-specific mosaics by Newsome (2000)
10.1101/gad.12.3.435 / Genes Dev / The Homothorax homeoprotein activates the nuclear localization of another homeoprotein, Extradenticle, and suppresses eye development in Drosophila by Pai (1998)
{'key': '2023090514444749000_DEVELOP_128_4_603C78', 'first-page': '543', 'article-title': 'cAMP-dependent protein kinase and hedgehog act antagonistically in regulating decapentaplegic transcription in Drosophila imaginal discs. Cell', 'volume': '80', 'author': 'Pan', 'year': '1995'} / cAMP-dependent protein kinase and hedgehog act antagonistically in regulating decapentaplegic transcription in Drosophila imaginal discs. Cell by Pan (1995)
10.1073/pnas.95.26.15508 / Proc. Natl. Acad. Sci. USA / Targeted expression of teashirt induces ectopic eyes in Drosophila by Pan (1998)
10.1126/science.281.5385.2031 / Science / Dorsal-ventral signaling in the Drosophila eye by Papayannopoulos (1998)
10.1242/dev.125.20.3955 / Development / The Drosophila trithorax group proteins BRM, ASH1 and ASH2 are subunits of distinct protein complexes by Papoulas (1998)
10.1016/S0925-4773(00)00372-5 / Mech. Dev / homothorax and iroquois-C genes are required for the establishment of territories within the developing eye disc by Pichaud (2000)
10.1016/S0092-8674(00)80480-8 / Cell / The eye specification proteins so and eya form a complex and regulate multiple steps in Drosophila eye development by Pignoni (1997)
10.1126/science.7914031 / Science / Homology of the eyeless gene of Drosophila to the Small eye gene in mice and Aniridia in humans by Quiring (1994)
10.1038/19783 / Nature / Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex by Rachez (1999)
10.1101/gad.12.12.1787 / Genes Dev / A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system by Rachez (1998)
10.1016/0012-1606(76)90225-6 / Dev. Biol / Development of the Drosophila retina, a neurocrystalline lattice by Ready (1976)
10.1002/neu.480220503 / J. Neurobiol / Characterization and spatial distribution of the ELAV protein during Drosophila melanogaster development by Robinow (1991)
10.1242/dev.124.23.4793 / Development / Establishing primordia in the Drosophila eye-antennal imaginal disc: the roles of decapentaplegic, wingless and hedgehog by Royet (1997)
10.1002/j.1460-2075.1989.tb08461.x / EMBO J / The Drosophila hairy protein acts in both segmentation and bristle patterning and shows homology to N-myc by Rushlow (1989)
10.1038/17141 / Nature / The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1 by Ryu (1999)
10.1242/dev.127.9.1879 / Development / The Drosophila homeobox gene optix is capable of inducing ectopic eyes by an eyeless-independent mechanism by Seimiya (2000)
10.1093/genetics/138.4.1137 / Genetics / sine oculis is a homeobox gene required for Drosophila visual system development by Serikaku (1994)
10.1242/dev.124.1.45 / Development / Ectopic eye development in Drosophila induced by directed dachshund expression by Shen (1997)
10.1242/dev.124.17.3233 / Development / Hedgehog is an indirect regulator of morphogenetic furrow progression in the Drosophila eye disc by Strutt (1997)
10.1038/373705a0 / Nature / Regulation of furrow progression in the Drosophila eye by cAMP-dependent protein kinase A by Strutt (1995)
10.1016/S1097-2765(00)80131-8 / Mol. Cell / tNAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription by Sun (1998)
10.1242/dev.122.12.3939 / Development / Developmental territories created by mutual antagonism between Wingless and Decapentaplegic by Theisen (1996)
10.1242/dev.124.2.343 / Development / The Drosophila TGFα homolog Spitz acts in photoreceptor recruitment in the developing retina by Tio (1997)
10.1242/dev.121.11.3519 / Development / wingless inhibits morphogenetic furrow movement in the Drosophila eye disc by Treisman (1995)
10.1006/dbio.1994.1203 / Dev. Biol / A cell-autonomous, ubiquitous marker for the analysis of Drosophila genetic mosaics by Vincent (1994)
10.1242/dev.122.7.2153 / Development / Mad acts downstream of dpp receptors, revealing a differential requirement for dpp signaling in initiation and propagation of morphogenesis in the Drosophila eye by Wiersdorff (1996)
10.1242/dev.126.1.109 / Development / Proximodistal axis formation in the Drosophila leg: subdivision into proximal and distal domains by Homothorax and Distal-less by Wu (1999)
10.1242/dev.117.4.1223 / Development / Analysis of genetic mosaics in developing and adult Drosophila tissues by Xu (1993)
10.1073/pnas.95.14.7939 / Proc. Natl. Acad. Sci. USA / The TRAP220 component of a thyroid hormone receptor-associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion by Yuan (1998)
10.1242/dev.124.13.2499 / Development / A role for ultraspiracle, the Drosophila RXR, in morphogenetic furrow movement and photoreceptor cluster formation by Zelhof (1997)
10.1101/gad.814700 / Genes Dev / A C. elegans mediator protein confers regulatory selectivity on lineage-specific expression of a transcription factor gene by Zhang (2000)

Dates

Type	When
Created	4 years, 4 months ago (April 26, 2021, 12:47 a.m.)
Deposited	1 year, 11 months ago (Sept. 5, 2023, 10:45 a.m.)
Indexed	3 weeks ago (Aug. 12, 2025, 5:33 p.m.)
Issued	24 years, 6 months ago (Feb. 15, 2001)
Published	24 years, 6 months ago (Feb. 15, 2001)
Published Online	24 years, 6 months ago (Feb. 15, 2001)
Published Print	24 years, 6 months ago (Feb. 15, 2001)

Funders 0

None

BibTeX

@article{Treisman_2001, title={Drosophila homologues of the transcriptional coactivation complex subunits TRAP240 and TRAP230 are required for identical processes in eye-antennal disc development}, volume={128}, ISSN={1477-9129}, url={http://dx.doi.org/10.1242/dev.128.4.603}, DOI={10.1242/dev.128.4.603}, number={4}, journal={Development}, publisher={The Company of Biologists}, author={Treisman, Jessica E.}, year={2001}, month=feb, pages={603–615} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        12
      ]
    ],
    "date-time": "2025-08-12T21:33:47Z",
    "timestamp": 1755034427002
  },
  "reference-count": 107,
  "publisher": "The Company of Biologists",
  "issue": "4",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2001,
            2,
            15
          ]
        ],
        "date-time": "2001-02-15T00:00:00Z",
        "timestamp": 982195200000
      },
      "content-version": "vor",
      "delay-in-days": 0,
      "URL": "http://www.biologists.com/user-licence-1-1/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2001,
        2,
        15
      ]
    ]
  },
  "abstract": "<jats:title>ABSTRACT</jats:title>\n               <jats:p>We have identified mutations in two genes, blind spot and kohtalo, that encode Drosophila homologues of human TRAP240 and TRAP230, components of a large transcriptional coactivation complex homologous to the yeast Mediator complex. Loss of either blind spot or kohtalo has identical effects on the development of the eye-antennal disc. Eye disc cells mutant for either gene can express decapentaplegic and atonal in response to Hedgehog signaling, but they maintain inappropriate expression of these genes and fail to differentiate further. Mutant cells in the antennal disc lose expression of Distal-less and misexpress eyeless, suggesting a partial transformation towards the eye fate. blind spot and kohtalo are not required for cell proliferation or survival, and their absence cannot be rescued by activation of the Hedgehog or Notch signaling pathways. These novel and specific phenotypes suggest that TRAP240 and TRAP230 act in concert to mediate an unknown developmental signal or a combination of signals.</jats:p>",
  "DOI": "10.1242/dev.128.4.603",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2021,
        4,
        26
      ]
    ],
    "date-time": "2021-04-26T04:47:36Z",
    "timestamp": 1619412456000
  },
  "page": "603-615",
  "source": "Crossref",
  "is-referenced-by-count": 99,
  "title": "<i>Drosophila</i> homologues of the transcriptional coactivation complex subunits TRAP240 and TRAP230 are required for identical processes in eye-antennal disc development",
  "prefix": "10.1242",
  "volume": "128",
  "author": [
    {
      "given": "Jessica E.",
      "family": "Treisman",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Skirball Institute for Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine , 540 First Avenue, New York, NY 10016, USA (e-mail: treisman@saturn.med.nyu.edu )"
        }
      ]
    }
  ],
  "member": "237",
  "published-online": {
    "date-parts": [
      [
        2001,
        2,
        15
      ]
    ]
  },
  "reference": [
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C1",
      "doi-asserted-by": "publisher",
      "first-page": "1043",
      "DOI": "10.1016/S0092-8674(00)80292-5",
      "article-title": "Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor",
      "volume": "89",
      "author": "Aza-Blanc",
      "year": "1997",
      "journal-title": "Cell"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C2",
      "doi-asserted-by": "publisher",
      "first-page": "3183",
      "DOI": "10.1101/gad.10.24.3183",
      "article-title": "Segmentation and specification of the Drosophila mesoderm",
      "volume": "10",
      "author": "Azpiazu",
      "year": "1996",
      "journal-title": "Genes Dev"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C3",
      "doi-asserted-by": "publisher",
      "first-page": "1290",
      "DOI": "10.1016/S0960-9822(02)70715-X",
      "article-title": "Evolution of proneural atonal expression during distinct regulatory phases in the developing Drosophila eye",
      "volume": "6",
      "author": "Baker",
      "year": "1996",
      "journal-title": "Curr. Biol"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C4",
      "doi-asserted-by": "publisher",
      "first-page": "122",
      "DOI": "10.1016/S0960-9822(06)00056-X",
      "article-title": "Proneural function of neurogenic genes in the developing Drosophila eye",
      "volume": "7",
      "author": "Baker",
      "year": "1997",
      "journal-title": "Curr. Biol"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C5",
      "doi-asserted-by": "publisher",
      "first-page": "271",
      "DOI": "10.1016/S0092-8674(00)80837-5",
      "article-title": "act up controls actin polymerization to alter cell shape and restrict Hedgehog signaling in the Drosophila eye disc",
      "volume": "101",
      "author": "Benlali",
      "year": "2000",
      "journal-title": "Cell"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C6",
      "doi-asserted-by": "publisher",
      "first-page": "657",
      "DOI": "10.1242/dev.111.3.657",
      "article-title": "An extensive 3\u2032 cis-regulatory region directs the imaginal disc expression of decapentaplegic, a member of the TGF-\u03b2 family in Drosophila",
      "volume": "111",
      "author": "Blackman",
      "year": "1991",
      "journal-title": "Development"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C7",
      "doi-asserted-by": "publisher",
      "first-page": "865",
      "DOI": "10.1016/S0092-8674(00)80799-0",
      "article-title": "Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4",
      "volume": "97",
      "author": "Bohni",
      "year": "1999",
      "journal-title": "Cell"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C8",
      "doi-asserted-by": "publisher",
      "first-page": "4819",
      "DOI": "10.1242/dev.124.23.4819",
      "article-title": "The Drosophila eyes absent gene directs ectopic eye formation in a pathway conserved between flies and vertebrates",
      "volume": "124",
      "author": "Bonini",
      "year": "1997",
      "journal-title": "Development"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C9",
      "doi-asserted-by": "publisher",
      "first-page": "379",
      "DOI": "10.1016/0092-8674(93)90115-7",
      "article-title": "The eyes absent gene: genetic control of cell survival and differentiation in the developing Drosophila eye",
      "volume": "72",
      "author": "Bonini",
      "year": "1993",
      "journal-title": "Cell"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C10",
      "doi-asserted-by": "publisher",
      "first-page": "187",
      "DOI": "10.1006/dbio.1998.8888",
      "article-title": "Mutual regulation of decapentaplegic and hedgehog during the initiation of differentiation in the Drosophila retina",
      "volume": "197",
      "author": "Borod",
      "year": "1998",
      "journal-title": "Dev. Biol"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C11",
      "first-page": "2906",
      "volume": "14",
      "author": "Boube",
      "year": "2000",
      "journal-title": "Drosophila homologs of transcriptional mediator complex subunits are required for adult cell and segment identity specification. Genes Dev"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C12",
      "doi-asserted-by": "publisher",
      "first-page": "276",
      "DOI": "10.1038/20466",
      "article-title": "Mammalian Srb/Mediator complex is targeted by adenovirus E1A protein",
      "volume": "399",
      "author": "Boyer",
      "year": "1999",
      "journal-title": "Nature"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C13",
      "doi-asserted-by": "publisher",
      "first-page": "1",
      "DOI": "10.1242/dev.128.1.1",
      "article-title": "Broad-complex, but not Ecdysone receptor, is required for progression of the morphogenetic furrow in the Drosophila eye",
      "volume": "128",
      "author": "Brennan",
      "year": "2001",
      "journal-title": "Development"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C14",
      "doi-asserted-by": "publisher",
      "first-page": "879",
      "DOI": "10.1016/0092-8674(95)90291-0",
      "article-title": "Hairy and emc negatively regulate morphogenetic furrow progression in the Drosophila eye",
      "volume": "80",
      "author": "Brown",
      "year": "1995",
      "journal-title": "Cell"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C15",
      "doi-asserted-by": "publisher",
      "first-page": "1245",
      "DOI": "10.1242/dev.113.4.1245",
      "article-title": "hairy genefunction in the Drosophila eye: normal expression is dispensable but ectopic expression alters cell fates",
      "volume": "113",
      "author": "Brown",
      "year": "1991",
      "journal-title": "Development"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C16",
      "doi-asserted-by": "publisher",
      "first-page": "360",
      "DOI": "10.1006/dbio.1996.0267",
      "article-title": "Hedgehog-dependent patterning in the Drosophila eye can occur in the absence of dpp signaling",
      "volume": "179",
      "author": "Burke",
      "year": "1996",
      "journal-title": "Dev. Biol"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C17",
      "first-page": "1099",
      "volume": "3",
      "author": "Cagan",
      "year": "1989",
      "journal-title": "Notch is required for successive cell decisions in the developingDrosophila retina. Genes Dev"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C18",
      "doi-asserted-by": "publisher",
      "first-page": "723",
      "DOI": "10.1038/33706",
      "article-title": "Control of antennal versus leg development in Drosophila",
      "volume": "392",
      "author": "Casares",
      "year": "1998",
      "journal-title": "Nature"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C19",
      "doi-asserted-by": "publisher",
      "first-page": "1921",
      "DOI": "10.1242/dev.127.9.1921",
      "article-title": "The Iroquois homeobox genes function as dorsal selectors in the Drosophila head",
      "volume": "127",
      "author": "Cavodeassi",
      "year": "2000",
      "journal-title": "Development"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C20",
      "doi-asserted-by": "publisher",
      "first-page": "559",
      "DOI": "10.1242/dev.124.2.559",
      "article-title": "Role of decapentaplegic in initiation and progression of the morphogenetic furrow in the developing Drosophila retina",
      "volume": "124",
      "author": "Chanut",
      "year": "1997",
      "journal-title": "Development"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C21",
      "doi-asserted-by": "publisher",
      "first-page": "893",
      "DOI": "10.1016/S0092-8674(00)80481-X",
      "article-title": "Dachshund and eyes absent proteins form a complex and function synergistically to induce ectopic eye development in Drosophila",
      "volume": "91",
      "author": "Chen",
      "year": "1997",
      "journal-title": "Cell"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C22",
      "doi-asserted-by": "publisher",
      "first-page": "3607",
      "DOI": "10.1242/dev.126.16.3607",
      "article-title": "Mutants of cubitus interruptus that are independent of PKA regulation are independent of hedgehog signaling",
      "volume": "126",
      "author": "Chen",
      "year": "1999",
      "journal-title": "Development"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C23",
      "doi-asserted-by": "publisher",
      "first-page": "977",
      "DOI": "10.1016/0896-6273(94)90308-5",
      "article-title": "The Drosophila sine oculis locus encodes a homeodomain-containing protein required for the development of the entire visual system",
      "volume": "12",
      "author": "Cheyette",
      "year": "1994",
      "journal-title": "Neuron"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C24",
      "doi-asserted-by": "publisher",
      "first-page": "272",
      "DOI": "10.1038/24394",
      "article-title": "Fringe is essential for mirror symmetry and morphogenesis in the Drosophila eye",
      "volume": "396",
      "author": "Cho",
      "year": "1998",
      "journal-title": "Nature"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C25",
      "doi-asserted-by": "publisher",
      "first-page": "331",
      "DOI": "10.1016/S0092-8674(00)00124-0",
      "article-title": "Novel signaling from the peripodial membrane is essential for eye disc patterning in Drosophila",
      "volume": "103",
      "author": "Cho",
      "year": "2000",
      "journal-title": "Cell"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C26",
      "doi-asserted-by": "publisher",
      "first-page": "7029",
      "DOI": "10.1093/emboj/18.24.7029",
      "article-title": "Osa associates with the Brahma chromatin remodeling complex and promotes the activation of some target genes",
      "volume": "18",
      "author": "Collins",
      "year": "1999",
      "journal-title": "EMBO J"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C27",
      "doi-asserted-by": "publisher",
      "first-page": "1159",
      "DOI": "10.1128/MCB.19.2.1159",
      "article-title": "The trithorax group gene moira encodes a brahma-associated putative chromatin-remodeling factor in Drosophila melanogaster",
      "volume": "19",
      "author": "Crosby",
      "year": "1999",
      "journal-title": "Mol. Cell. Biol"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C28",
      "doi-asserted-by": "publisher",
      "first-page": "1325",
      "DOI": "10.1242/dev.127.6.1325",
      "article-title": "Morphogenetic furrow initiation and progression during eye development in Drosophila: the roles of decapentaplegic, hedgehog and eyes absent",
      "volume": "127",
      "author": "Curtiss",
      "year": "2000",
      "journal-title": "Development"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C29",
      "doi-asserted-by": "publisher",
      "first-page": "297",
      "DOI": "10.1016/S1097-2765(00)80457-8",
      "article-title": "twin of eyeless, a second Pax-6 gene of Drosophila, acts upstream of eyeless in the control of eye development",
      "volume": "3",
      "author": "Czerny",
      "year": "1999",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C30",
      "doi-asserted-by": "publisher",
      "first-page": "726",
      "DOI": "10.1006/dbio.1995.1251",
      "article-title": "A nuclear GFP that marks nuclei in living Drosophila embryos; maternal supply overcomes a delay in the appearance of zygotic fluorescence",
      "volume": "170",
      "author": "Davis",
      "year": "1995",
      "journal-title": "Dev. Biol"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C31",
      "doi-asserted-by": "publisher",
      "first-page": "175",
      "DOI": "10.1038/372175a0",
      "article-title": "Cell interaction between compartments establishes the proximal-distal axis of Drosophila legs",
      "volume": "372",
      "author": "Diaz-Benjumea",
      "year": "1994",
      "journal-title": "Nature"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C32",
      "doi-asserted-by": "publisher",
      "first-page": "421",
      "DOI": "10.1101/gad.10.4.421",
      "article-title": "Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation",
      "volume": "10",
      "author": "Doherty",
      "year": "1996",
      "journal-title": "Genes Dev"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C33",
      "doi-asserted-by": "publisher",
      "first-page": "276",
      "DOI": "10.1038/24402",
      "article-title": "A dorsal/ventral boundary established by Notch controls growth and polarity in the Drosophila eye",
      "volume": "396",
      "author": "Dominguez",
      "year": "1998",
      "journal-title": "Nature"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C34",
      "doi-asserted-by": "publisher",
      "first-page": "2345",
      "DOI": "10.1242/dev.126.11.2345",
      "article-title": "Dual role for hedgehog in the regulation of the proneural gene atonal during ommatidia development",
      "volume": "126",
      "author": "Dominguez",
      "year": "1999",
      "journal-title": "Development"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C35",
      "doi-asserted-by": "publisher",
      "first-page": "3254",
      "DOI": "10.1101/gad.11.23.3254",
      "article-title": "Hedgehog directly controls initiation and propagation of retinal differentiation in the Drosophila eye",
      "volume": "11",
      "author": "Dominguez",
      "year": "1997",
      "journal-title": "Genes Dev"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C36",
      "doi-asserted-by": "publisher",
      "first-page": "1039",
      "DOI": "10.1016/S0960-9822(98)70441-5",
      "article-title": "Multiple functions of the EGF receptor in Drosophila eye development",
      "volume": "8",
      "author": "Dominguez",
      "year": "1998",
      "journal-title": "Curr. Biol"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C37",
      "doi-asserted-by": "publisher",
      "first-page": "209",
      "DOI": "10.1242/dev.127.2.209",
      "article-title": "Coexpression of the homeobox genes Distal-less and homothorax determines Drosophila antennal identity",
      "volume": "127",
      "author": "Dong",
      "year": "2000",
      "journal-title": "Development"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C38",
      "doi-asserted-by": "publisher",
      "first-page": "2263",
      "DOI": "10.1242/dev.125.12.2263",
      "article-title": "Identifying loci required for follicular patterning using directed mosaics",
      "volume": "125",
      "author": "Duffy",
      "year": "1998",
      "journal-title": "Development"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C39",
      "doi-asserted-by": "publisher",
      "first-page": "8329",
      "DOI": "10.1073/pnas.93.16.8329",
      "article-title": "Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex",
      "volume": "93",
      "author": "Fondell",
      "year": "1996",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C40",
      "doi-asserted-by": "publisher",
      "first-page": "651",
      "DOI": "10.1016/S0092-8674(00)81385-9",
      "article-title": "Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye",
      "volume": "87",
      "author": "Freeman",
      "year": "1996",
      "journal-title": "Cell"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C41",
      "doi-asserted-by": "publisher",
      "first-page": "5795",
      "DOI": "10.1242/dev.126.24.5795",
      "article-title": "Progression of the morphogenetic furrow in the Drosophila eye: the roles of Hedgehog, Decapentaplegic and the Raf pathway",
      "volume": "126",
      "author": "Greenwood",
      "year": "1999",
      "journal-title": "Development"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C42",
      "doi-asserted-by": "publisher",
      "first-page": "97",
      "DOI": "10.1016/S1097-2765(00)80178-1",
      "article-title": "A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation",
      "volume": "3",
      "author": "Gu",
      "year": "1999",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C43",
      "doi-asserted-by": "publisher",
      "first-page": "2181",
      "DOI": "10.1242/dev.125.12.2181",
      "article-title": "Eyeless initiates the expression of both sine oculis and eyes absent during Drosophila compound eye development",
      "volume": "125",
      "author": "Halder",
      "year": "1998",
      "journal-title": "Development"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C44",
      "doi-asserted-by": "publisher",
      "first-page": "1788",
      "DOI": "10.1126/science.7892602",
      "article-title": "Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila",
      "volume": "267",
      "author": "Halder",
      "year": "1995",
      "journal-title": "Science"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C45",
      "doi-asserted-by": "publisher",
      "first-page": "3741",
      "DOI": "10.1242/dev.125.18.3741",
      "article-title": "decapentaplegic and wingless are regulated by eyes absent and eyegone and interact to direct the pattern of retinal differentiation in the eye disc",
      "volume": "125",
      "author": "Hazelett",
      "year": "1998",
      "journal-title": "Development"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C46",
      "doi-asserted-by": "publisher",
      "first-page": "709",
      "DOI": "10.1038/373709a0",
      "article-title": "Growth and differentiation in the Drosophila eye coordinated by hedgehog",
      "volume": "373",
      "author": "Heberlein",
      "year": "1995",
      "journal-title": "Nature"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C47",
      "doi-asserted-by": "publisher",
      "first-page": "913",
      "DOI": "10.1016/0092-8674(93)90535-X",
      "article-title": "The TGF\u03b2 homolog dpp and the segment polarity gene hedgehog are required for propagation of a morphogenetic wave in the Drosophila retina",
      "volume": "75",
      "author": "Heberlein",
      "year": "1993",
      "journal-title": "Cell"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C48",
      "doi-asserted-by": "publisher",
      "first-page": "5380",
      "DOI": "10.1093/emboj/18.19.5380",
      "article-title": "Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins",
      "volume": "18",
      "author": "Hittelman",
      "year": "1999",
      "journal-title": "EMBO J"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C49",
      "doi-asserted-by": "publisher",
      "first-page": "361",
      "DOI": "10.1016/S1097-2765(00)80463-3",
      "article-title": "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators",
      "volume": "3",
      "author": "Ito",
      "year": "1999",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C50",
      "doi-asserted-by": "publisher",
      "first-page": "683",
      "DOI": "10.1016/S1097-2765(00)80247-6",
      "article-title": "Involvement of the TRAP220 component of the TRAP/SMCC coactivator complex in embryonic development and thyroid hormone action",
      "volume": "5",
      "author": "Ito",
      "year": "2000",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C51",
      "doi-asserted-by": "publisher",
      "first-page": "529",
      "DOI": "10.1016/S0092-8674(00)80657-1",
      "article-title": "gigas, a Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle",
      "volume": "96",
      "author": "Ito",
      "year": "1999",
      "journal-title": "Cell"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C52",
      "doi-asserted-by": "publisher",
      "first-page": "1307",
      "DOI": "10.1016/0092-8674(93)90358-W",
      "article-title": "atonal is a proneural gene that directs chordotonal organ formation in the Drosophila peripheral nervous system",
      "volume": "73",
      "author": "Jarman",
      "year": "1993",
      "journal-title": "Cell"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C53",
      "doi-asserted-by": "publisher",
      "first-page": "398",
      "DOI": "10.1038/369398a0",
      "article-title": "atonal is the proneural gene for Drosophila photoreceptors",
      "volume": "369",
      "author": "Jarman",
      "year": "1994",
      "journal-title": "Nature"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C54",
      "doi-asserted-by": "publisher",
      "first-page": "2019",
      "DOI": "10.1242/dev.121.7.2019",
      "article-title": "Role of the proneural gene, atonal, in formation of Drosophila chordotonal organs and photoreceptors",
      "volume": "121",
      "author": "Jarman",
      "year": "1995",
      "journal-title": "Development"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C55",
      "doi-asserted-by": "publisher",
      "first-page": "8538",
      "DOI": "10.1073/pnas.95.15.8538",
      "article-title": "Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways",
      "volume": "95",
      "author": "Jiang",
      "year": "1998",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C56",
      "doi-asserted-by": "publisher",
      "first-page": "1919",
      "DOI": "10.1073/pnas.89.5.1919",
      "article-title": "Altering the insertional specificity of a Drosophila transposable element",
      "volume": "89",
      "author": "Kassis",
      "year": "1992",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C57",
      "doi-asserted-by": "publisher",
      "first-page": "8136",
      "DOI": "10.1073/pnas.85.21.8136",
      "article-title": "Dosage-dependent modifiers of Polycomb and Antennapedia mutations in Drosophila",
      "volume": "85",
      "author": "Kennison",
      "year": "1988",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C58",
      "doi-asserted-by": "publisher",
      "first-page": "599",
      "DOI": "10.1016/0092-8674(94)90221-6",
      "article-title": "A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II",
      "volume": "77",
      "author": "Kim",
      "year": "1994",
      "journal-title": "Cell"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C59",
      "doi-asserted-by": "publisher",
      "first-page": "2339",
      "DOI": "10.1101/gad.13.18.2339",
      "article-title": "ATP-dependent remodeling and acetylation as regulators of chromatin fluidity",
      "volume": "13",
      "author": "Kingston",
      "year": "1999",
      "journal-title": "Genes Dev"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C60",
      "doi-asserted-by": "publisher",
      "first-page": "3875",
      "DOI": "10.1242/dev.125.19.3875",
      "article-title": "Dissecting the roles of the Drosophila EGF receptor in eye development and MAP kinase activation",
      "volume": "125",
      "author": "Kumar",
      "year": "1998",
      "journal-title": "Development"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C61",
      "doi-asserted-by": "publisher",
      "first-page": "2117",
      "DOI": "10.1073/pnas.040556497",
      "article-title": "Notch signaling and the determination of appendage identity",
      "volume": "97",
      "author": "Kurata",
      "year": "2000",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C62",
      "doi-asserted-by": "publisher",
      "first-page": "14990",
      "DOI": "10.1073/pnas.96.26.14990",
      "article-title": "Caenorhabditis elegans mediator complexes are required for developmental-specific transcriptional activation",
      "volume": "96",
      "author": "Kwon",
      "year": "1999",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C63",
      "doi-asserted-by": "publisher",
      "first-page": "139",
      "DOI": "10.1038/40563",
      "article-title": "Proximal-distal axis formation in the Drosophila leg",
      "volume": "388",
      "author": "Lecuit",
      "year": "1997",
      "journal-title": "Nature"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C64",
      "doi-asserted-by": "publisher",
      "first-page": "129",
      "DOI": "10.1006/dbio.1998.9121",
      "article-title": "Several levels of EGF receptor signaling during photoreceptor specification in wild-type, Ellipse, and null mutant Drosophila",
      "volume": "205",
      "author": "Lesokhin",
      "year": "1999",
      "journal-title": "Dev. Biol"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C65",
      "doi-asserted-by": "publisher",
      "first-page": "927",
      "DOI": "10.1016/0092-8674(93)90536-Y",
      "article-title": "The segment polarity gene hedgehog is required for progression of the morphogenetic furrow in the developing Drosophila eye",
      "volume": "75",
      "author": "Ma",
      "year": "1993",
      "journal-title": "Cell"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C66",
      "doi-asserted-by": "publisher",
      "first-page": "2279",
      "DOI": "10.1242/dev.121.8.2279",
      "article-title": "wingless and patched are negative regulators of the morphogenetic furrow and can affect tissue polarity in the developing Drosophila compound eye",
      "volume": "121",
      "author": "Ma",
      "year": "1995",
      "journal-title": "Development"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C67",
      "doi-asserted-by": "publisher",
      "first-page": "753",
      "DOI": "10.1016/S1097-2765(00)80254-3",
      "article-title": "The USA-derived transcriptional coactivator PC2 is a submodule of TRAP/SMCC and acts synergistically with other PCs",
      "volume": "5",
      "author": "Malik",
      "year": "2000",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C68",
      "doi-asserted-by": "publisher",
      "first-page": "277",
      "DOI": "10.1016/S0968-0004(00)01596-6",
      "article-title": "Transcriptional regulation through mediator-like coactivators in yeast and metazoan cells",
      "volume": "25",
      "author": "Malik",
      "year": "2000",
      "journal-title": "Trends Biochem. Sci"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C69",
      "doi-asserted-by": "publisher",
      "first-page": "3473",
      "DOI": "10.1242/dev.120.12.3473",
      "article-title": "dachsund encodes a nuclear protein required for normal eye and leg development in Drosophila",
      "volume": "120",
      "author": "Mardon",
      "year": "1994",
      "journal-title": "Development"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C70",
      "doi-asserted-by": "publisher",
      "first-page": "1007",
      "DOI": "10.1242/dev.127.5.1007",
      "article-title": "pannier acts upstream of wingless to direct dorsal eye disc development in Drosophila",
      "volume": "127",
      "author": "Maurel-Zaffran",
      "year": "2000",
      "journal-title": "Development"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C71",
      "doi-asserted-by": "publisher",
      "first-page": "1848",
      "DOI": "10.1101/gad.4.11.1848",
      "article-title": "Isolation and expression of scabrous, a gene regulating neurogenesis in Drosophila",
      "volume": "4",
      "author": "Mlodzik",
      "year": "1990",
      "journal-title": "Genes Dev"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C72",
      "first-page": "211",
      "volume": "42",
      "author": "Morata",
      "year": "1975",
      "journal-title": "Minutes: mutants autonomously affecting cell division rate in Drosophila. Dev. Biol"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C73",
      "doi-asserted-by": "publisher",
      "first-page": "614",
      "DOI": "10.1038/255614a0",
      "article-title": "Control of compartment development by the engrailed gene in Drosophila",
      "volume": "255",
      "author": "Morata",
      "year": "1975",
      "journal-title": "Nature"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C74",
      "doi-asserted-by": "publisher",
      "first-page": "137",
      "DOI": "10.1016/0925-4773(95)00397-J",
      "article-title": "The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways",
      "volume": "52",
      "author": "Motzny",
      "year": "1995",
      "journal-title": "Mech. Dev"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C75",
      "doi-asserted-by": "publisher",
      "first-page": "828",
      "DOI": "10.1038/19789",
      "article-title": "Composite co-activator ARC mediates chromatin-directed transcriptional activation",
      "volume": "398",
      "author": "Naar",
      "year": "1999",
      "journal-title": "Nature"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C76",
      "doi-asserted-by": "publisher",
      "first-page": "851",
      "DOI": "10.1242/dev.127.4.851",
      "article-title": "Analysis of Drosophila photoreceptor axon guidance in eye-specific mosaics",
      "volume": "127",
      "author": "Newsome",
      "year": "2000",
      "journal-title": "Development"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C77",
      "doi-asserted-by": "publisher",
      "first-page": "435",
      "DOI": "10.1101/gad.12.3.435",
      "article-title": "The Homothorax homeoprotein activates the nuclear localization of another homeoprotein, Extradenticle, and suppresses eye development in Drosophila",
      "volume": "12",
      "author": "Pai",
      "year": "1998",
      "journal-title": "Genes Dev"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C78",
      "first-page": "543",
      "article-title": "cAMP-dependent protein kinase and hedgehog act antagonistically in regulating decapentaplegic transcription in Drosophila imaginal discs. Cell",
      "volume": "80",
      "author": "Pan",
      "year": "1995"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C79",
      "doi-asserted-by": "publisher",
      "first-page": "15508",
      "DOI": "10.1073/pnas.95.26.15508",
      "article-title": "Targeted expression of teashirt induces ectopic eyes in Drosophila",
      "volume": "95",
      "author": "Pan",
      "year": "1998",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C80",
      "doi-asserted-by": "publisher",
      "first-page": "2031",
      "DOI": "10.1126/science.281.5385.2031",
      "article-title": "Dorsal-ventral signaling in the Drosophila eye",
      "volume": "281",
      "author": "Papayannopoulos",
      "year": "1998",
      "journal-title": "Science"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C81",
      "doi-asserted-by": "publisher",
      "first-page": "3955",
      "DOI": "10.1242/dev.125.20.3955",
      "article-title": "The Drosophila trithorax group proteins BRM, ASH1 and ASH2 are subunits of distinct protein complexes",
      "volume": "125",
      "author": "Papoulas",
      "year": "1998",
      "journal-title": "Development"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C82",
      "doi-asserted-by": "publisher",
      "first-page": "15",
      "DOI": "10.1016/S0925-4773(00)00372-5",
      "article-title": "homothorax and iroquois-C genes are required for the establishment of territories within the developing eye disc",
      "volume": "96",
      "author": "Pichaud",
      "year": "2000",
      "journal-title": "Mech. Dev"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C83",
      "doi-asserted-by": "publisher",
      "first-page": "881",
      "DOI": "10.1016/S0092-8674(00)80480-8",
      "article-title": "The eye specification proteins so and eya form a complex and regulate multiple steps in Drosophila eye development",
      "volume": "91",
      "author": "Pignoni",
      "year": "1997",
      "journal-title": "Cell"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C84",
      "doi-asserted-by": "publisher",
      "first-page": "785",
      "DOI": "10.1126/science.7914031",
      "article-title": "Homology of the eyeless gene of Drosophila to the Small eye gene in mice and Aniridia in humans",
      "volume": "265",
      "author": "Quiring",
      "year": "1994",
      "journal-title": "Science"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C85",
      "doi-asserted-by": "publisher",
      "first-page": "824",
      "DOI": "10.1038/19783",
      "article-title": "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex",
      "volume": "398",
      "author": "Rachez",
      "year": "1999",
      "journal-title": "Nature"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C86",
      "doi-asserted-by": "publisher",
      "first-page": "1787",
      "DOI": "10.1101/gad.12.12.1787",
      "article-title": "A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system",
      "volume": "12",
      "author": "Rachez",
      "year": "1998",
      "journal-title": "Genes Dev"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C87",
      "doi-asserted-by": "publisher",
      "first-page": "217",
      "DOI": "10.1016/0012-1606(76)90225-6",
      "article-title": "Development of the Drosophila retina, a neurocrystalline lattice",
      "volume": "53",
      "author": "Ready",
      "year": "1976",
      "journal-title": "Dev. Biol"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C88",
      "doi-asserted-by": "publisher",
      "first-page": "443",
      "DOI": "10.1002/neu.480220503",
      "article-title": "Characterization and spatial distribution of the ELAV protein during Drosophila melanogaster development",
      "volume": "22",
      "author": "Robinow",
      "year": "1991",
      "journal-title": "J. Neurobiol"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C89",
      "doi-asserted-by": "publisher",
      "first-page": "4793",
      "DOI": "10.1242/dev.124.23.4793",
      "article-title": "Establishing primordia in the Drosophila eye-antennal imaginal disc: the roles of decapentaplegic, wingless and hedgehog",
      "volume": "124",
      "author": "Royet",
      "year": "1997",
      "journal-title": "Development"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C90",
      "doi-asserted-by": "publisher",
      "first-page": "3095",
      "DOI": "10.1002/j.1460-2075.1989.tb08461.x",
      "article-title": "The Drosophila hairy protein acts in both segmentation and bristle patterning and shows homology to N-myc",
      "volume": "8",
      "author": "Rushlow",
      "year": "1989",
      "journal-title": "EMBO J"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C91",
      "doi-asserted-by": "publisher",
      "first-page": "446",
      "DOI": "10.1038/17141",
      "article-title": "The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1",
      "volume": "397",
      "author": "Ryu",
      "year": "1999",
      "journal-title": "Nature"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C92",
      "doi-asserted-by": "publisher",
      "first-page": "1879",
      "DOI": "10.1242/dev.127.9.1879",
      "article-title": "The Drosophila homeobox gene optix is capable of inducing ectopic eyes by an eyeless-independent mechanism",
      "volume": "127",
      "author": "Seimiya",
      "year": "2000",
      "journal-title": "Development"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C93",
      "doi-asserted-by": "publisher",
      "first-page": "1137",
      "DOI": "10.1093/genetics/138.4.1137",
      "article-title": "sine oculis is a homeobox gene required for Drosophila visual system development",
      "volume": "138",
      "author": "Serikaku",
      "year": "1994",
      "journal-title": "Genetics"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C94",
      "doi-asserted-by": "publisher",
      "first-page": "45",
      "DOI": "10.1242/dev.124.1.45",
      "article-title": "Ectopic eye development in Drosophila induced by directed dachshund expression",
      "volume": "124",
      "author": "Shen",
      "year": "1997",
      "journal-title": "Development"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C95",
      "doi-asserted-by": "publisher",
      "first-page": "3233",
      "DOI": "10.1242/dev.124.17.3233",
      "article-title": "Hedgehog is an indirect regulator of morphogenetic furrow progression in the Drosophila eye disc",
      "volume": "124",
      "author": "Strutt",
      "year": "1997",
      "journal-title": "Development"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C96",
      "doi-asserted-by": "publisher",
      "first-page": "705",
      "DOI": "10.1038/373705a0",
      "article-title": "Regulation of furrow progression in the Drosophila eye by cAMP-dependent protein kinase A",
      "volume": "373",
      "author": "Strutt",
      "year": "1995",
      "journal-title": "Nature"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C97",
      "doi-asserted-by": "publisher",
      "first-page": "213",
      "DOI": "10.1016/S1097-2765(00)80131-8",
      "article-title": "tNAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription",
      "volume": "2",
      "author": "Sun",
      "year": "1998",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C98",
      "doi-asserted-by": "publisher",
      "first-page": "3939",
      "DOI": "10.1242/dev.122.12.3939",
      "article-title": "Developmental territories created by mutual antagonism between Wingless and Decapentaplegic",
      "volume": "122",
      "author": "Theisen",
      "year": "1996",
      "journal-title": "Development"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C99",
      "doi-asserted-by": "publisher",
      "first-page": "343",
      "DOI": "10.1242/dev.124.2.343",
      "article-title": "The Drosophila TGF\u03b1 homolog Spitz acts in photoreceptor recruitment in the developing retina",
      "volume": "124",
      "author": "Tio",
      "year": "1997",
      "journal-title": "Development"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C100",
      "doi-asserted-by": "publisher",
      "first-page": "3519",
      "DOI": "10.1242/dev.121.11.3519",
      "article-title": "wingless inhibits morphogenetic furrow movement in the Drosophila eye disc",
      "volume": "121",
      "author": "Treisman",
      "year": "1995",
      "journal-title": "Development"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C101",
      "doi-asserted-by": "publisher",
      "first-page": "328",
      "DOI": "10.1006/dbio.1994.1203",
      "article-title": "A cell-autonomous, ubiquitous marker for the analysis of Drosophila genetic mosaics",
      "volume": "164",
      "author": "Vincent",
      "year": "1994",
      "journal-title": "Dev. Biol"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C102",
      "doi-asserted-by": "publisher",
      "first-page": "2153",
      "DOI": "10.1242/dev.122.7.2153",
      "article-title": "Mad acts downstream of dpp receptors, revealing a differential requirement for dpp signaling in initiation and propagation of morphogenesis in the Drosophila eye",
      "volume": "122",
      "author": "Wiersdorff",
      "year": "1996",
      "journal-title": "Development"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C103",
      "doi-asserted-by": "publisher",
      "first-page": "109",
      "DOI": "10.1242/dev.126.1.109",
      "article-title": "Proximodistal axis formation in the Drosophila leg: subdivision into proximal and distal domains by Homothorax and Distal-less",
      "volume": "126",
      "author": "Wu",
      "year": "1999",
      "journal-title": "Development"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C104",
      "doi-asserted-by": "publisher",
      "first-page": "1223",
      "DOI": "10.1242/dev.117.4.1223",
      "article-title": "Analysis of genetic mosaics in developing and adult Drosophila tissues",
      "volume": "117",
      "author": "Xu",
      "year": "1993",
      "journal-title": "Development"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C105",
      "doi-asserted-by": "publisher",
      "first-page": "7939",
      "DOI": "10.1073/pnas.95.14.7939",
      "article-title": "The TRAP220 component of a thyroid hormone receptor-associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion",
      "volume": "95",
      "author": "Yuan",
      "year": "1998",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C106",
      "doi-asserted-by": "publisher",
      "first-page": "2499",
      "DOI": "10.1242/dev.124.13.2499",
      "article-title": "A role for ultraspiracle, the Drosophila RXR, in morphogenetic furrow movement and photoreceptor cluster formation",
      "volume": "124",
      "author": "Zelhof",
      "year": "1997",
      "journal-title": "Development"
    },
    {
      "key": "2023090514444749000_DEVELOP_128_4_603C107",
      "doi-asserted-by": "publisher",
      "first-page": "2161",
      "DOI": "10.1101/gad.814700",
      "article-title": "A C. elegans mediator protein confers regulatory selectivity on lineage-specific expression of a transcription factor gene",
      "volume": "14",
      "author": "Zhang",
      "year": "2000",
      "journal-title": "Genes Dev"
    }
  ],
  "container-title": "Development",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://journals.biologists.com/dev/article-pdf/128/4/603/3129492/develop_128_4_603.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "syndication"
    },
    {
      "URL": "https://journals.biologists.com/dev/article-pdf/128/4/603/3129492/develop_128_4_603.pdf",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        9,
        5
      ]
    ],
    "date-time": "2023-09-05T14:45:05Z",
    "timestamp": 1693925105000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://journals.biologists.com/dev/article/128/4/603/41619/Drosophila-homologues-of-the-transcriptional"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2001,
        2,
        15
      ]
    ]
  },
  "references-count": 107,
  "journal-issue": {
    "issue": "4",
    "published-print": {
      "date-parts": [
        [
          2001,
          2,
          15
        ]
      ]
    }
  },
  "URL": "http://dx.doi.org/10.1242/dev.128.4.603",
  "relation": {},
  "ISSN": [
    "0950-1991",
    "1477-9129"
  ],
  "subject": [],
  "published": {
    "date-parts": [
      [
        2001,
        2,
        15
      ]
    ]
  }
}