DOI: 10.1242/dev.127.3.457. A local Wnt-3a signal is required for development of the mammalian hippocampus

A local Wnt-3a signal is required for development of the mammalian hippocampus

10.1242/dev.127.3.457

Crossref journal-article

The Company of Biologists

Development (237)

Abstract

ABSTRACT The mechanisms that regulate patterning and growth of the developing cerebral cortex remain unclear. Suggesting a role for Wnt signaling in these processes, multiple Wnt genes are expressed in selective patterns in the embryonic cortex. We have examined the role of Wnt-3a signaling at the caudomedial margin of the developing cerebral cortex, the site of hippocampal development. We show that Wnt-3a acts locally to regulate the expansion of the caudomedial cortex, from which the hippocampus develops. In mice lacking Wnt-3a, caudomedial cortical progenitor cells appear to be specified normally, but then underproliferate. By mid-gestation, the hippocampus is missing or represented by tiny populations of residual hippocampal cells. Thus, Wnt-3a signaling is crucial for the normal growth of the hippocampus. We suggest that the coordination of growth with patterning may be a general role for Wnts during vertebrate development.

Bibliography

Lee, S. M. K., Tole, S., Grove, E. A., & McMahon, A. P. (2000). A local Wnt-3a signal is required for development of the mammalian hippocampus. Development, 127(3), 457â467.

Authors 4

Scott M. K. Lee (first)
Shubha Tole (additional)
Elizabeth A. Grove (additional)
Andrew P. McMahon (additional)

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Dates

Type	When
Created	4 years, 4 months ago (April 26, 2021, 12:23 a.m.)
Deposited	1 year, 10 months ago (Oct. 9, 2023, 9:24 a.m.)
Indexed	2 days, 12 hours ago (Sept. 3, 2025, 6:04 a.m.)
Issued	25 years, 7 months ago (Feb. 1, 2000)
Published	25 years, 7 months ago (Feb. 1, 2000)
Published Online	25 years, 7 months ago (Feb. 1, 2000)
Published Print	25 years, 7 months ago (Feb. 1, 2000)

Funders 0

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BibTeX

@article{Lee_2000, title={A local Wnt-3a signal is required for development of the mammalian hippocampus}, volume={127}, ISSN={1477-9129}, url={http://dx.doi.org/10.1242/dev.127.3.457}, DOI={10.1242/dev.127.3.457}, number={3}, journal={Development}, publisher={The Company of Biologists}, author={Lee, Scott M. K. and Tole, Shubha and Grove, Elizabeth A. and McMahon, Andrew P.}, year={2000}, month=feb, pages={457–467} }

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