DOI: 10.1242/dev.127.15.3349. Molecular mechanisms of hormone-mediated Müllerian duct regression: involvement of β-catenin

Molecular mechanisms of hormone-mediated Müllerian duct regression: involvement of β-catenin

10.1242/dev.127.15.3349

Crossref journal-article

The Company of Biologists

Development (237)

Abstract

ABSTRACT Regression of the Müllerian duct in the male embryo is one unequivocal effect of anti-Müllerian hormone, a glycoprotein secreted by the Sertoli cells of the testis. This hormone induces ductal epithelial regression through a paracrine mechanism originating in periductal mesenchyme. To probe the mechanisms of action of anti-Müllerian hormone, we have studied the sequence of cellular and molecular events involved in duct regression. Studies were performed in male rat embryos and in transgenic mice overexpressing or lacking anti-Müllerian hormone, both in vivo and in vitro Anti-Müllerian hormone causes regression of the cranial part of the Müllerian duct whereas it continues to grow caudally. Our work shows that this pattern of regression is correlated with a cranial to caudal gradient of anti-Müllerian hormone receptor protein, followed by a wave of apoptosis spreading along the Müllerian duct as its progresses caudally. Apoptosis is also induced by AMH in female Müllerian duct in vitro. Furthermore, apoptotic indexes are increased in Müllerian epithelium of transgenic mice of both sexes overexpressing the human anti-Müllerian hormone gene, exhibiting a positive correlation with serum hormone concentration. Inversely, apoptosis is reduced in male anti-Müllerian hormone-deficient mice. We also show that apoptosis is a decisive but not sufficient process, and that epitheliomesenchymal transformation is an important event of Müllerian regression. The most striking result of this study is that anti-Müllerian hormone action in peri-Müllerian mesenchyme leads in vivo and in vitro to an accumulation of cytoplasmic β-catenin. The co-localization ofβ-catenin with lymphoid enhancer factor 1 in the nucleus of peri-Müllerian mesenchymal cells, demonstrated in primary culture, suggests that overexpressed β-catenin in association with lymphoid enhancer factor 1 may alter transcription of target genes and may lead to changes in mesenchymal gene expression and cell fate during Müllerian duct regression. To our knowledge, this is the first report thatβ-catenin, known for its role in Wnt signaling, may mediate anti-Müllerian hormone action.

Bibliography

Allard, S., Adin, P., GouÃ©dard, L., Clemente, N. di, Josso, N., Orgebin-Crist, M.-C., Picard, J.-Y., & Xavier, F. (2000). Molecular mechanisms of hormone-mediated MÃ¼llerian duct regression: involvement of Î²-catenin. Development, 127(15), 3349â3360.

Authors 8

Séverine Allard (first)
Peggy Adin (additional)
Lucile Gouédard (additional)
Nathalie di Clemente (additional)
Nathalie Josso (additional)
Marie-Claire Orgebin-Crist (additional)
Jean-Yves Picard (additional)
Françoise Xavier (additional)

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Dates

Type	When
Created	4 years, 4 months ago (April 26, 2021, 12:12 a.m.)
Deposited	1 year, 8 months ago (Dec. 25, 2023, 6:54 p.m.)
Indexed	2 months, 2 weeks ago (June 9, 2025, 2:47 a.m.)
Issued	25 years ago (Aug. 1, 2000)
Published	25 years ago (Aug. 1, 2000)
Published Online	25 years ago (Aug. 1, 2000)
Published Print	25 years ago (Aug. 1, 2000)

Funders 0

None

BibTeX

@article{Allard_2000, title={Molecular mechanisms of hormone-mediated Müllerian duct regression: involvement of β-catenin}, volume={127}, ISSN={1477-9129}, url={http://dx.doi.org/10.1242/dev.127.15.3349}, DOI={10.1242/dev.127.15.3349}, number={15}, journal={Development}, publisher={The Company of Biologists}, author={Allard, Séverine and Adin, Peggy and Gouédard, Lucile and Clemente, Nathalie di and Josso, Nathalie and Orgebin-Crist, Marie-Claire and Picard, Jean-Yves and Xavier, Françoise}, year={2000}, month=aug, pages={3349–3360} }

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  "abstract": "<jats:title>ABSTRACT</jats:title>\n               <jats:p>Regression of the M\u00fcllerian duct in the male embryo is one unequivocal effect of anti-M\u00fcllerian hormone, a glycoprotein secreted by the Sertoli cells of the testis. This hormone induces ductal epithelial regression through a paracrine mechanism originating in periductal mesenchyme. To probe the mechanisms of action of anti-M\u00fcllerian hormone, we have studied the sequence of cellular and molecular events involved in duct regression. Studies were performed in male rat embryos and in transgenic mice overexpressing or lacking anti-M\u00fcllerian hormone, both in vivo and in vitro</jats:p>\n               <jats:p>Anti-M\u00fcllerian hormone causes regression of the cranial part of the M\u00fcllerian duct whereas it continues to grow caudally. Our work shows that this pattern of regression is correlated with a cranial to caudal gradient of anti-M\u00fcllerian hormone receptor protein, followed by a wave of apoptosis spreading along the M\u00fcllerian duct as its progresses caudally. Apoptosis is also induced by AMH in female M\u00fcllerian duct in vitro. Furthermore, apoptotic indexes are increased in M\u00fcllerian epithelium of transgenic mice of both sexes overexpressing the human anti-M\u00fcllerian hormone gene, exhibiting a positive correlation with serum hormone concentration. Inversely, apoptosis is reduced in male anti-M\u00fcllerian hormone-deficient mice. We also show that apoptosis is a decisive but not sufficient process, and that epitheliomesenchymal transformation is an important event of M\u00fcllerian regression.</jats:p>\n               <jats:p>The most striking result of this study is that anti-M\u00fcllerian hormone action in peri-M\u00fcllerian mesenchyme leads in vivo and in vitro to an accumulation of cytoplasmic \u03b2-catenin. The co-localization of\u03b2-catenin with lymphoid enhancer factor 1 in the nucleus of peri-M\u00fcllerian mesenchymal cells, demonstrated in primary culture, suggests that overexpressed \u03b2-catenin in association with lymphoid enhancer factor 1 may alter transcription of target genes and may lead to changes in mesenchymal gene expression and cell fate during M\u00fcllerian duct regression. To our knowledge, this is the first report that\u03b2-catenin, known for its role in Wnt signaling, may mediate anti-M\u00fcllerian hormone action.</jats:p>",
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