DOI: 10.1242/dev.126.4.607. Patterning of the R7 and R8 photoreceptor cells of <i>Drosophila</i>: evidence for induced and default cell-fate specification

Patterning of the R7 and R8 photoreceptor cells of Drosophila: evidence for induced and default cell-fate specification

10.1242/dev.126.4.607

Crossref journal-article

The Company of Biologists

Development (237)

Abstract

Abstract Opsin gene expression in the R7 and R8 photoreceptor cells of the Drosophila compound eye is highly coordinated. We have found that the R8 cell specific Rh5 and Rh6 opsins are expressed in non-overlapping sets of R8 cells, in a precise pairwise fashion with Rh3 and Rh4 in the R7 cells of individual ommatidia. Removal of the R7 cells in sevenless, boss or sina mutants, disrupts Rh5 expression and dramatically increases the number of Rh6-expressing R8 cells. This suggests that the expression of Rh5 may be induced by an Rh3-expressing R7 cell, whereas Rh6 expression is most likely a default state of the R8 cell. We found that the paired expression of opsin genes in the R7 and R8 cells occurs in a sevenless and boss independent manner. Furthermore, we found that the generation of both Rh3- and Rh4-expressing R7 cells can occur in the absence of an R8 cell. These results suggest that the specification of opsin expression in the R7 cells may occur autonomously, whereas the R7 photoreceptor cell may be responsible for regulating a binary developmental switch between induced and default cell-fates in the R8 cell.

Bibliography

Chou, W.-H., Huber, A., Bentrop, J., Schulz, S., Schwab, K., Chadwell, L. V., Paulsen, R., & Britt, S. G. (1999). Patterning of the R7 and R8 photoreceptor cells of Drosophila: evidence for induced and default cell-fate specification. Development, 126(4), 607â616.

Authors 8

Wen-Hai Chou (first)
Armin Huber (additional)
Joachim Bentrop (additional)
Simone Schulz (additional)
Karin Schwab (additional)
Linda V. Chadwell (additional)
Reinhard Paulsen (additional)
Steven G. Britt (additional)

References 46 Referenced 136

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Dates

Type	When
Created	4 years, 4 months ago (April 25, 2021, 11:59 p.m.)
Deposited	1 year, 11 months ago (Sept. 5, 2023, 11:29 a.m.)
Indexed	1 month, 3 weeks ago (July 7, 2025, 4:46 a.m.)
Issued	26 years, 6 months ago (Feb. 15, 1999)
Published	26 years, 6 months ago (Feb. 15, 1999)
Published Online	26 years, 6 months ago (Feb. 15, 1999)
Published Print	26 years, 6 months ago (Feb. 15, 1999)

Funders 0

None

BibTeX

@article{Chou_1999, title={Patterning of the R7 and R8 photoreceptor cells of Drosophila: evidence for induced and default cell-fate specification}, volume={126}, ISSN={1477-9129}, url={http://dx.doi.org/10.1242/dev.126.4.607}, DOI={10.1242/dev.126.4.607}, number={4}, journal={Development}, publisher={The Company of Biologists}, author={Chou, Wen-Hai and Huber, Armin and Bentrop, Joachim and Schulz, Simone and Schwab, Karin and Chadwell, Linda V. and Paulsen, Reinhard and Britt, Steven G.}, year={1999}, month=feb, pages={607–616} }

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