DOI: 10.1242/dev.126.24.5819. Patterning of dopaminergic neurotransmitter identity among <i>Caenorhabditis elegans</i> ray sensory neurons by a TGFβfamily signaling pathway and a <i>Hox</i> gene

Patterning of dopaminergic neurotransmitter identity among Caenorhabditis elegans ray sensory neurons by a TGFβfamily signaling pathway and a Hox gene

10.1242/dev.126.24.5819

Crossref journal-article

The Company of Biologists

Development (237)

Abstract

Abstract We have investigated the mechanism that patterns dopamine expression among Caenorhabditis elegans male ray sensory neurons. Dopamine is expressed by the A-type sensory neurons in three out of the nine pairs of rays. We used expression of a tyrosine hydroxylase reporter transgene as well as direct assays for dopamine to study the genetic requirements for adoption of the dopaminergic cell fate. In loss-of-function mutants affecting a TGFβ family signaling pathway, the DBL-1 pathway, dopaminergic identity is adopted irregularly by a wider subset of the rays. Ectopic expression of the pathway ligand, DBL-1, from a heat-shock-driven transgene results in adoption of dopaminergic identity by rays 3-9; rays 1 and 2 are refractory. The rays are therefore prepatterned with respect to their competence to be induced by a DBL-1 pathway signal. Temperature-shift experiments with a temperature-sensitive type II receptor mutant, as well as heat-shock induction experiments, show that the DBL-1 pathway acts during an interval that extends from two to one cell generation before ray neurons are born and begin to differentiate. In a mutant of the AbdominalB class Hox gene egl-5, rays that normally express EGL-5 do not adopt dopaminergic fate and cannot be induced to express DA when DBL-1 is provided by a heat-shock-driven dbl-1 transgene. Therefore, egl-5 is required for making a subset of rays capable of adopting dopaminergic identity, while the function of the DBL-1 pathway signal is to pattern the realization of this capability.

Bibliography

Lints, R., & Emmons, S. W. (1999). Patterning of dopaminergic neurotransmitter identity among Caenorhabditis elegans ray sensory neurons by a TGFÎ²family signaling pathway and a Hox gene. Development, 126(24), 5819â5831.

Authors 2

Robyn Lints (first)
Scott W. Emmons (additional)

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Dates

Type	When
Created	4 years, 4 months ago (April 25, 2021, 11:58 p.m.)
Deposited	1 year, 11 months ago (Sept. 6, 2023, 4:07 a.m.)
Indexed	33 minutes ago (Aug. 27, 2025, 9:01 p.m.)
Issued	25 years, 8 months ago (Dec. 15, 1999)
Published	25 years, 8 months ago (Dec. 15, 1999)
Published Online	25 years, 8 months ago (Dec. 15, 1999)
Published Print	25 years, 8 months ago (Dec. 15, 1999)

Funders 0

None

BibTeX

@article{Lints_1999, title={Patterning of dopaminergic neurotransmitter identity among Caenorhabditis elegans ray sensory neurons by a TGFβfamily signaling pathway and a Hox gene}, volume={126}, ISSN={1477-9129}, url={http://dx.doi.org/10.1242/dev.126.24.5819}, DOI={10.1242/dev.126.24.5819}, number={24}, journal={Development}, publisher={The Company of Biologists}, author={Lints, Robyn and Emmons, Scott W.}, year={1999}, month=dec, pages={5819–5831} }

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  "abstract": "<jats:title>Abstract</jats:title>\n               <jats:p>We have investigated the mechanism that patterns dopamine expression among Caenorhabditis elegans male ray sensory neurons. Dopamine is expressed by the A-type sensory neurons in three out of the nine pairs of rays. We used expression of a tyrosine hydroxylase reporter transgene as well as direct assays for dopamine to study the genetic requirements for adoption of the dopaminergic cell fate. In loss-of-function mutants affecting a TGF\u03b2 family signaling pathway, the DBL-1 pathway, dopaminergic identity is adopted irregularly by a wider subset of the rays. Ectopic expression of the pathway ligand, DBL-1, from a heat-shock-driven transgene results in adoption of dopaminergic identity by rays 3-9; rays 1 and 2 are refractory. The rays are therefore prepatterned with respect to their competence to be induced by a DBL-1 pathway signal. Temperature-shift experiments with a temperature-sensitive type II receptor mutant, as well as heat-shock induction experiments, show that the DBL-1 pathway acts during an interval that extends from two to one cell generation before ray neurons are born and begin to differentiate. In a mutant of the AbdominalB class Hox gene egl-5, rays that normally express EGL-5 do not adopt dopaminergic fate and cannot be induced to express DA when DBL-1 is provided by a heat-shock-driven dbl-1 transgene. Therefore, egl-5 is required for making a subset of rays capable of adopting dopaminergic identity, while the function of the DBL-1 pathway signal is to pattern the realization of this capability.</jats:p>",
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