DOI: 10.1242/dev.126.23.5365. PTEN affects cell size, cell proliferation and apoptosis during <i>Drosophila</i> eye development

PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development

10.1242/dev.126.23.5365

Crossref journal-article

The Company of Biologists

Development (237)

Abstract

Abstract Mutations in the tumor suppressor gene PTEN (MMAC1/TEP1) are associated with a large number of human cancers and several autosomal-dominant disorders. Mice mutant for PTEN die at early embryonic stages and the mutant embryonic fibroblasts display decreased sensitivity to cell death. Overexpression of PTEN in different mammalian tissue culture cells affects various processes including cell proliferation, cell death and cell migration. We have characterized the Drosophila PTEN gene and present evidence that both inactivation and overexpression of PTEN affect cell size, while overexpression of PTEN also inhibits cell cycle progression at early mitosis and promotes cell death during eye development in a context-dependent manner. Furthermore, we have shown that PTEN acts in the insulin signaling pathway and all signals from the insulin receptor can be antagonized by either Drosophila or human PTEN, suggesting a potential means for alleviating symptoms associated with altered insulin signaling.

Bibliography

Huang, H., Potter, C. J., Tao, W., Li, D.-M., Brogiolo, W., Hafen, E., Sun, H., & Xu, T. (1999). PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development. Development, 126(23), 5365â5372.

Authors 8

He Huang (first)
Christopher J. Potter (additional)
Wufan Tao (additional)
Da-Ming Li (additional)
Walter Brogiolo (additional)
Ernst Hafen (additional)
Hong Sun (additional)
Tian Xu (additional)

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Dates

Type	When
Created	4 years, 4 months ago (April 25, 2021, 11:55 p.m.)
Deposited	1 year, 11 months ago (Sept. 6, 2023, 4:06 a.m.)
Indexed	2 months ago (July 1, 2025, 12:42 p.m.)
Issued	25 years, 9 months ago (Dec. 1, 1999)
Published	25 years, 9 months ago (Dec. 1, 1999)
Published Online	25 years, 9 months ago (Dec. 1, 1999)
Published Print	25 years, 9 months ago (Dec. 1, 1999)

Funders 0

None

BibTeX

@article{Huang_1999, title={PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development}, volume={126}, ISSN={1477-9129}, url={http://dx.doi.org/10.1242/dev.126.23.5365}, DOI={10.1242/dev.126.23.5365}, number={23}, journal={Development}, publisher={The Company of Biologists}, author={Huang, He and Potter, Christopher J. and Tao, Wufan and Li, Da-Ming and Brogiolo, Walter and Hafen, Ernst and Sun, Hong and Xu, Tian}, year={1999}, month=dec, pages={5365–5372} }

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