DOI: 10.1242/dev.126.16.3585. Role of<i>Pax6</i>in development of the cerebellar system

Role ofPax6in development of the cerebellar system

10.1242/dev.126.16.3585

Crossref journal-article

The Company of Biologists

Development (237)

Abstract

AbstractPost-mitotic neurons generated at the rhombic lip undertake long distance migration to widely dispersed destinations, giving rise to cerebellar granule cells and the precerebellar nuclei. Here we show that Pax6, a key regulator in CNS and eye development, is strongly expressed in rhombic lip and in cells migrating away from it. Development of some structures derived from these cells is severely affected in Pax6-null Small eye (Pax6Sey/Pax6Sey) embryos. Cell proliferation and initial differentiation seem unaffected, but cell migration and neurite extension are disrupted in mutant embryos. Three of the five precerebellar nuclei fail to form correctly. In the cerebellum the pre-migratory granule cell sub-layer and fissures are absent. Some granule cells are found in ectopic positions in the inferior colliculus which may result from the complete absence of Unc5h3 expression in Pax6Sey/Pax6Sey granule cells. Our results suggest that Pax6 plays a strong role during hindbrain migration processes and at least part of its activity is mediated through regulation of the netrin receptor Unc5h3.

Bibliography

Engelkamp, D., Rashbass, P., Seawright, A., & Heyningen, V. van. (1999). Role ofPax6in development of the cerebellar system. Development, 126(16), 3585â3596.

Authors 4

Dieter Engelkamp (first)
Penny Rashbass (additional)
Anne Seawright (additional)
Veronica van Heyningen (additional)

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Dates

Type	When
Created	4 years, 4 months ago (April 26, 2021, 4:40 p.m.)
Deposited	1 year ago (Aug. 29, 2024, 5:46 a.m.)
Indexed	5 days, 16 hours ago (Aug. 30, 2025, 1:17 p.m.)
Issued	26 years ago (Aug. 15, 1999)
Published	26 years ago (Aug. 15, 1999)
Published Online	26 years ago (Aug. 15, 1999)
Published Print	26 years ago (Aug. 15, 1999)

Funders 0

None

BibTeX

@article{Engelkamp_1999, title={Role ofPax6in development of the cerebellar system}, volume={126}, ISSN={1477-9129}, url={http://dx.doi.org/10.1242/dev.126.16.3585}, DOI={10.1242/dev.126.16.3585}, number={16}, journal={Development}, publisher={The Company of Biologists}, author={Engelkamp, Dieter and Rashbass, Penny and Seawright, Anne and Heyningen, Veronica van}, year={1999}, month=aug, pages={3585–3596} }

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