DOI: 10.1242/dev.126.1.23. NeuroD regulates multiple functions in the developing neural retina in rodent

NeuroD regulates multiple functions in the developing neural retina in rodent

10.1242/dev.126.1.23

Crossref journal-article

The Company of Biologists

Development (237)

Abstract

ABSTRACT The expression and function of the basic helix-loop-helix (bHLH) transcription factor NeuroD were studied in the developing neural retina in rodent. neuroD was expressed in areas of undetermined retinal cells as well as developing photoreceptors and amacrine interneurons. Expression was maintained in a subset of mature photoreceptors in the adult retina. Using both loss-of-function and gain-of-function approaches, NeuroD was found to play multiple roles in retinal development. (1) NeuroD was found to be a critical regulator of the neuron versus glial cell fate decision. Retinal explants derived from NeuroD-null mice demonstrated a three-to fourfold increase in Müller glia. Forced expression of neuroD in progenitors in rat using retroviruses hastened cell cycle withdrawal and blocked gliogenesis in vivo. (2) NeuroD appeared to regulate interneuron development, favouring amacrine over bipolar differentiation. Forced NeuroD expression resulted in an increase in amacrine interneurons and a decrease in bipolar interneurons. In the complementary experiment, retinae derived from NeuroD-null mice demonstrated a twofold increase in bipolar interneurons and a delay in amacrine differentiation. (3) NeuroD appeared to be essential for the survival of a subset of rod photoreceptors. In conclusion, these results implicate NeuroD in a variety of developmental functions including cell fate determination, differentiation and neuron survival.

Bibliography

Morrow, E. M., Furukawa, T., Lee, J. E., & Cepko, C. L. (1999). NeuroD regulates multiple functions in the developing neural retina in rodent. Development, 126(1), 23â36.

Authors 4

Eric M. Morrow (first)
Takahisa Furukawa (additional)
Jacqueline E. Lee (additional)
Constance L. Cepko (additional)

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Dates

Type	When
Created	4 years, 4 months ago (April 23, 2021, 3:30 p.m.)
Deposited	2 years, 3 months ago (May 11, 2023, 7:44 a.m.)
Indexed	1 month, 1 week ago (July 22, 2025, 6:31 a.m.)
Issued	26 years, 8 months ago (Jan. 1, 1999)
Published	26 years, 8 months ago (Jan. 1, 1999)
Published Online	26 years, 8 months ago (Jan. 1, 1999)
Published Print	26 years, 8 months ago (Jan. 1, 1999)

Funders 0

None

BibTeX

@article{Morrow_1999, title={NeuroD regulates multiple functions in the developing neural retina in rodent}, volume={126}, ISSN={1477-9129}, url={http://dx.doi.org/10.1242/dev.126.1.23}, DOI={10.1242/dev.126.1.23}, number={1}, journal={Development}, publisher={The Company of Biologists}, author={Morrow, Eric M. and Furukawa, Takahisa and Lee, Jacqueline E. and Cepko, Constance L.}, year={1999}, month=jan, pages={23–36} }

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  },
  "URL": "http://dx.doi.org/10.1242/dev.126.1.23",
  "relation": {},
  "ISSN": [
    "0950-1991",
    "1477-9129"
  ],
  "subject": [],
  "published": {
    "date-parts": [
      [
        1999,
        1,
        1
      ]
    ]
  }
}