DOI: 10.1242/dev.125.20.4089. miranda localizes staufen and prospero asymmetrically in mitotic neuroblasts and epithelial cells in early <i>Drosophila</i> embryogenesis

miranda localizes staufen and prospero asymmetrically in mitotic neuroblasts and epithelial cells in early Drosophila embryogenesis

10.1242/dev.125.20.4089

Crossref journal-article

The Company of Biologists

Development (237)

Abstract

ABSTRACT When neuroblasts divide, prospero protein and mRNA segregate asymmetrically into the daughter neuroblast and sibling ganglion mother cell. miranda is known to localize prospero protein to the basal cell cortex of neuroblasts while the staufen RNA-binding protein mediates prospero mRNA localization. Here we show that miranda is required for asymmetric staufen localization in neuroblasts. Analyses using miranda mutants reveal that prospero and staufen interact with miranda under the same cell-cycle-dependent control. miranda thus acts to partition both prospero protein and mRNA. Furthermore, miranda localizes prospero and staufen to the basolateral cortex in dividing epithelial cells, which express the three proteins prior to neurogenesis. Our observations suggest that the epithelial cell and neuroblast (both of epithelial origin) share the same molecular machinery for creating cellular asymmetry.

Bibliography

Matsuzaki, F., Ohshiro, T., Ikeshima-Kataoka, H., & Izumi, H. (1998). miranda localizes staufen and prospero asymmetrically in mitotic neuroblasts and epithelial cells in early Drosophila embryogenesis. Development, 125(20), 4089â4098.

Authors 4

Fumio Matsuzaki (first)
Tomokazu Ohshiro (additional)
Hiroko Ikeshima-Kataoka (additional)
Hitomi Izumi (additional)

References 42 Referenced 107

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Dates

Type	When
Created	4 years, 4 months ago (April 25, 2021, 11:25 p.m.)
Deposited	6 months, 2 weeks ago (Feb. 14, 2025, 8:59 p.m.)
Indexed	1 week, 3 days ago (Aug. 21, 2025, 12:46 p.m.)
Issued	26 years, 10 months ago (Oct. 15, 1998)
Published	26 years, 10 months ago (Oct. 15, 1998)
Published Online	26 years, 10 months ago (Oct. 15, 1998)
Published Print	26 years, 10 months ago (Oct. 15, 1998)

Funders 0

None

BibTeX

@article{Matsuzaki_1998, title={miranda localizes staufen and prospero asymmetrically in mitotic neuroblasts and epithelial cells in early Drosophila embryogenesis}, volume={125}, ISSN={1477-9129}, url={http://dx.doi.org/10.1242/dev.125.20.4089}, DOI={10.1242/dev.125.20.4089}, number={20}, journal={Development}, publisher={The Company of Biologists}, author={Matsuzaki, Fumio and Ohshiro, Tomokazu and Ikeshima-Kataoka, Hiroko and Izumi, Hitomi}, year={1998}, month=oct, pages={4089–4098} }

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