DOI: 10.1242/dev.125.11.2041. <i>Thylacine 1</i> is expressed segmentally within the paraxial mesoderm of the <i>Xenopus</i> embryo and interacts with the Notch pathway

Thylacine 1 is expressed segmentally within the paraxial mesoderm of the Xenopus embryo and interacts with the Notch pathway

10.1242/dev.125.11.2041

Crossref journal-article

The Company of Biologists

Development (237)

Abstract

ABSTRACT The presomitic mesoderm of vertebrates undergoes a process of segmentation in which cell-cell interactions mediated by the Notch family of receptors and their associated ligands are involved. The vertebrate homologues of Drosophila Delta are expressed in a dynamic, segmental pattern within the presomitic mesoderm, and alterations in the function of these genes leads to a perturbed pattern of somite segmentation. In this study we have characterised Thylacine 1 which encodes a basic helix-loop-helix class transcription activator. Expression of Thylacine is restricted to the presomitic mesoderm, localising to the anterior half of several somitomeres in register with domains of X-Delta-2 expression. Ectopic expression of Thylacine in embryos causes segmentation defects similar to those seen in embryos in which Notch signalling is altered, and these embryos also show severe disruption in the expression patterns of the marker genes X-Delta-2 and X-ESR5 within the presomitic mesoderm. Finally, the expression of Thylacine is altered in embryos when Notch signalling is perturbed. These observations suggest strongly that Thylacine 1 has a role in the segmentation pathway of the Xenopus embryo, by interacting with the Notch signalling pathway.

Bibliography

Sparrow, D. B., Jen, W.-C., Kotecha, S., Towers, N., Kintner, C., & Mohun, T. J. (1998). Thylacine 1 is expressed segmentally within the paraxial mesoderm of the Xenopus embryo and interacts with the Notch pathway. Development, 125(11), 2041â2051.

Authors 6

Duncan B. Sparrow (first)
Wui-Chuong Jen (additional)
Surendra Kotecha (additional)
Norma Towers (additional)
Chris Kintner (additional)
Timothy J. Mohun (additional)

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Dates

Type	When
Created	4 years, 4 months ago (April 25, 2021, 11:14 p.m.)
Deposited	6 months, 2 weeks ago (Feb. 14, 2025, 8:14 p.m.)
Indexed	6 months, 2 weeks ago (Feb. 14, 2025, 8:40 p.m.)
Issued	27 years, 2 months ago (June 1, 1998)
Published	27 years, 2 months ago (June 1, 1998)
Published Online	27 years, 2 months ago (June 1, 1998)
Published Print	27 years, 2 months ago (June 1, 1998)

Funders 0

None

BibTeX

@article{Sparrow_1998, title={Thylacine 1 is expressed segmentally within the paraxial mesoderm of the Xenopus embryo and interacts with the Notch pathway}, volume={125}, ISSN={1477-9129}, url={http://dx.doi.org/10.1242/dev.125.11.2041}, DOI={10.1242/dev.125.11.2041}, number={11}, journal={Development}, publisher={The Company of Biologists}, author={Sparrow, Duncan B. and Jen, Wui-Chuong and Kotecha, Surendra and Towers, Norma and Kintner, Chris and Mohun, Timothy J.}, year={1998}, month=jun, pages={2041–2051} }

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