DOI: 10.1242/dev.124.3.693. The <i>Xenopus</i> homolog of <i>Drosophila Suppressor of Hairless</i> mediates Notch signaling during primary neurogenesis

The Xenopus homolog of Drosophila Suppressor of Hairless mediates Notch signaling during primary neurogenesis

10.1242/dev.124.3.693

Crossref journal-article

The Company of Biologists

Development (237)

Abstract

ABSTRACT The X-Notch-1 receptor, and its putative ligand, X-Delta-1, are thought to mediate an inhibitory cell-cell interaction, called lateral inhibition, that limits the number of primary neurons that form in Xenopus embryos. The expression of Xenopus ESR-1, a gene related to Drosophila Enhancer of split, appears to be induced by Notch signaling during this process. To determine how the activation of X-Notch-1 induces ESR-1 expression and regulates primary neurogenesis, we isolated the Xenopus homolog of Suppressor of Hairless (X-Su(H)), a component of the Notch signaling pathway in Drosophila. Using animal cap assays, we show that X-Su(H) induces ESR-1 expression, perhaps directly, when modified by the addition of ankyrin repeats. Using a DNA binding mutant of X-Su(H), we show that X-Su(H) activity is required for induction of ESR-1. Finally, expression of the DNA binding mutant in embryos leads to a neurogenic phenotype as well as increased expression of both X-Delta-1 and XNGNR1, a proneural gene expressed during primary neurogenesis. These results suggest that activation of X-Su(H) is a key step in the Notch signaling pathway during primary neurogenesis in Xenopus embryos.

Bibliography

Wettstein, D. A., Turner, D. L., & Kintner, C. (1997). The Xenopus homolog of Drosophila Suppressor of Hairless mediates Notch signaling during primary neurogenesis. Development, 124(3), 693â702.

Authors 3

Daniel A. Wettstein (first)
David L. Turner (additional)
Chris Kintner (additional)

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Dates

Type	When
Created	4 years, 3 months ago (April 25, 2021, 11:13 p.m.)
Deposited	6 months, 1 week ago (Feb. 13, 2025, 7:13 p.m.)
Indexed	6 months, 1 week ago (Feb. 14, 2025, 12:34 a.m.)
Issued	28 years, 6 months ago (Feb. 1, 1997)
Published	28 years, 6 months ago (Feb. 1, 1997)
Published Online	28 years, 6 months ago (Feb. 1, 1997)
Published Print	28 years, 6 months ago (Feb. 1, 1997)

Funders 0

None

BibTeX

@article{Wettstein_1997, title={The Xenopus homolog of Drosophila Suppressor of Hairless mediates Notch signaling during primary neurogenesis}, volume={124}, ISSN={1477-9129}, url={http://dx.doi.org/10.1242/dev.124.3.693}, DOI={10.1242/dev.124.3.693}, number={3}, journal={Development}, publisher={The Company of Biologists}, author={Wettstein, Daniel A. and Turner, David L. and Kintner, Chris}, year={1997}, month=feb, pages={693–702} }

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  "abstract": "<jats:title>ABSTRACT</jats:title>\n               <jats:p>The X-Notch-1 receptor, and its putative ligand, X-Delta-1, are thought to mediate an inhibitory cell-cell interaction, called lateral inhibition, that limits the number of primary neurons that form in Xenopus embryos. The expression of Xenopus ESR-1, a gene related to Drosophila Enhancer of split, appears to be induced by Notch signaling during this process. To determine how the activation of X-Notch-1 induces ESR-1 expression and regulates primary neurogenesis, we isolated the Xenopus homolog of Suppressor of Hairless (X-Su(H)), a component of the Notch signaling pathway in Drosophila. Using animal cap assays, we show that X-Su(H) induces ESR-1 expression, perhaps directly, when modified by the addition of ankyrin repeats. Using a DNA binding mutant of X-Su(H), we show that X-Su(H) activity is required for induction of ESR-1. Finally, expression of the DNA binding mutant in embryos leads to a neurogenic phenotype as well as increased expression of both X-Delta-1 and XNGNR1, a proneural gene expressed during primary neurogenesis. These results suggest that activation of X-Su(H) is a key step in the Notch signaling pathway during primary neurogenesis in Xenopus embryos.</jats:p>",
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