DOI: 10.1242/dev.124.17.3283. Feedback regulation is central to Delta-Notch signalling required for <i>Drosophila</i> wing vein morphogenesis

Feedback regulation is central to Delta-Notch signalling required for Drosophila wing vein morphogenesis

10.1242/dev.124.17.3283

Crossref journal-article

The Company of Biologists

Development (237)

Abstract

ABSTRACT Delta and Notch are required for partitioning of vein and intervein cell fates within the provein during Drosophila metamorphosis. We find that partitioning of these fates is dependent on Delta-mediated signalling from 22 to 30 hours after puparium formation at 25°C. Within the provein, Delta is expressed more highly in central provein cells (presumptive vein cells) and Notch is expressed more highly in lateral provein cells (presumptive intervein cells). Accumulation of Notch in presumptive intervein cells is dependent on Delta signalling activity in presumptive vein cells and constitutive Notch receptor activity represses Delta accumulation in presumptive vein cells. When Delta protein expression is elevated ectopically in presumptive intervein cells, complementary Delta and Notch expression patterns in provein cells are reversed, and vein loss occurs because central provein cells are unable to stably adopt the vein cell fate. Our findings imply that Delta-Notch signalling exerts feedback regulation on Delta and Notch expression during metamorphic wing vein development, and that the resultant asymmetries in Delta and Notch expression underlie the proper specification of vein and intervein cell fates within the provein.

Bibliography

Huppert, S. S., Jacobsen, T. L., & Muskavitch, M. A. T. (1997). Feedback regulation is central to Delta-Notch signalling required for Drosophila wing vein morphogenesis. Development, 124(17), 3283â3291.

Authors 3

Stacey S. Huppert (first)
Thomas L. Jacobsen (additional)
Marc A. T. Muskavitch (additional)

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Dates

Type	When
Created	4 years, 4 months ago (April 25, 2021, 10:54 p.m.)
Deposited	6 months, 2 weeks ago (Feb. 13, 2025, 11:37 p.m.)
Indexed	2 months, 2 weeks ago (June 11, 2025, 11:49 a.m.)
Issued	28 years ago (Sept. 1, 1997)
Published	28 years ago (Sept. 1, 1997)
Published Online	28 years ago (Sept. 1, 1997)
Published Print	28 years ago (Sept. 1, 1997)

Funders 0

None

BibTeX

@article{Huppert_1997, title={Feedback regulation is central to Delta-Notch signalling required for Drosophila wing vein morphogenesis}, volume={124}, ISSN={1477-9129}, url={http://dx.doi.org/10.1242/dev.124.17.3283}, DOI={10.1242/dev.124.17.3283}, number={17}, journal={Development}, publisher={The Company of Biologists}, author={Huppert, Stacey S. and Jacobsen, Thomas L. and Muskavitch, Marc A. T.}, year={1997}, month=sep, pages={3283–3291} }

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  "abstract": "<jats:title>ABSTRACT</jats:title>\n               <jats:p>Delta and Notch are required for partitioning of vein and intervein cell fates within the provein during Drosophila metamorphosis. We find that partitioning of these fates is dependent on Delta-mediated signalling from 22 to 30 hours after puparium formation at 25\u00b0C. Within the provein, Delta is expressed more highly in central provein cells (presumptive vein cells) and Notch is expressed more highly in lateral provein cells (presumptive intervein cells). Accumulation of Notch in presumptive intervein cells is dependent on Delta signalling activity in presumptive vein cells and constitutive Notch receptor activity represses Delta accumulation in presumptive vein cells. When Delta protein expression is elevated ectopically in presumptive intervein cells, complementary Delta and Notch expression patterns in provein cells are reversed, and vein loss occurs because central provein cells are unable to stably adopt the vein cell fate. Our findings imply that Delta-Notch signalling exerts feedback regulation on Delta and Notch expression during metamorphic wing vein development, and that the resultant asymmetries in Delta and Notch expression underlie the proper specification of vein and intervein cell fates within the provein.</jats:p>",
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