DOI: 10.1242/dev.124.16.3037. <i>Xenopus msx1</i> mediates epidermal induction and neural inhibition by BMP4

Xenopus msx1 mediates epidermal induction and neural inhibition by BMP4

10.1242/dev.124.16.3037

Crossref journal-article

The Company of Biologists

Development (237)

Abstract

ABSTRACT Epidermal fate in Xenopus ectoderm has been shown to be induced by a secreted growth factor, Bone Morphogenetic Protein 4 (BMP4). However, the molecular mechanism mediating this response is poorly understood. Here, we show that the expression of the homeobox gene, msx1, is an immediate early response to BMP4 in Xenopus embryos. The timing of expression and embryonic distribution of msx1 parallel those described for BMP4. Moreover, over-expression of msx1 in early Xenopus embryos leads to their ventralization as described for BMP4. Consistent with mediating a BMP type of signaling, overexpression of msx1 is sufficient to induce epidermis in dissociated ectoderm cells, which would otherwise form neural tissue. Finally, msx1 can also rescue neuralization imposed by a dominant negative BMP receptor (tBR) in ectodermal explants. We propose that Xenopus msx1 acts as a mediator of BMP signaling in epidermal induction and inhibition of neural differentiation.

Bibliography

Suzuki, A., Ueno, N., & Hemmati-Brivanlou, A. (1997). Xenopus msx1 mediates epidermal induction and neural inhibition by BMP4. Development, 124(16), 3037â3044.

Authors 3

Atsushi Suzuki (first)
Naoto Ueno (additional)
Ali Hemmati-Brivanlou (additional)

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Dates

Type	When
Created	4 years, 4 months ago (April 23, 2021, 3:12 p.m.)
Deposited	6 months, 3 weeks ago (Feb. 13, 2025, 11:27 p.m.)
Indexed	6 months, 3 weeks ago (Feb. 15, 2025, 12:05 a.m.)
Issued	28 years ago (Aug. 15, 1997)
Published	28 years ago (Aug. 15, 1997)
Published Online	28 years ago (Aug. 15, 1997)
Published Print	28 years ago (Aug. 15, 1997)

Funders 0

None

BibTeX

@article{Suzuki_1997, title={Xenopus msx1 mediates epidermal induction and neural inhibition by BMP4}, volume={124}, ISSN={1477-9129}, url={http://dx.doi.org/10.1242/dev.124.16.3037}, DOI={10.1242/dev.124.16.3037}, number={16}, journal={Development}, publisher={The Company of Biologists}, author={Suzuki, Atsushi and Ueno, Naoto and Hemmati-Brivanlou, Ali}, year={1997}, month=aug, pages={3037–3044} }

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  "resource": {
    "primary": {
      "URL": "https://journals.biologists.com/dev/article/124/16/3037/39402/Xenopus-msx1-mediates-epidermal-induction-and"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
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        8,
        15
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    ]
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  "references-count": 70,
  "journal-issue": {
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  "URL": "http://dx.doi.org/10.1242/dev.124.16.3037",
  "relation": {},
  "ISSN": [
    "0950-1991",
    "1477-9129"
  ],
  "subject": [],
  "published": {
    "date-parts": [
      [
        1997,
        8,
        15
      ]
    ]
  }
}