DOI: 10.1242/dev.123.1.345. Jaw and branchial arch mutants in zebrafish II: anterior arches and cartilage differentiation

Jaw and branchial arch mutants in zebrafish II: anterior arches and cartilage differentiation

10.1242/dev.123.1.345

Crossref journal-article

The Company of Biologists

Development (237)

Abstract

ABSTRACT In a large scale screen for mutants that affect the early development of the zebrafish, 109 mutants were found that cause defects in the formation of the jaw and the more posterior pharyngeal arches. Here we present the phenotypic description and results of the complementation analysis of mutants belonging to two major classes: (1) mutants with defects in the mandibular and hyoid arches and (2) mutants with defects in cartilage differentiation and growth in all arches. Mutations in four of the genes identified during the screen show specific defects in the first two arches and leave the more posterior pharyngeal arches largely unaffected (schmerle, sucker, hoover and sturgeon). In these mutants ventral components of the mandibular and hyoid arches are reduced (Meckel’s cartilage and ceratohyal cartilage) whereas dorsal structures (palatoquadrate and hyosymplectic cartilages) are of normal size or enlarged. Thus, mutations in single genes cause defects in the formation of first and second arch structures but also differentially affect development of the dorsal and ventral structures within one arch. In 27 mutants that define at least 8 genes, the differentiation of cartilage and growth is affected. In hammerhead mutants particularly the mesodermally derived cartilages are reduced, whereas jellyfish mutant larvae are characterized by a severe reduction of all cartilaginous elements, leaving only two pieces in the position of the ceratohyal cartilages. In all other mutant larvae all skeletal elements are present, but consist of smaller and disorganized chondrocytes. These mutants also exhibit shortened heads and reduced pectoral fins. In homozygous knorrig embryos, tumor-like outgrowths of chondrocytes occur along the edges of all cartilaginous elements. The mutants presented here may be valuable tools for elucidating the genetic mechanisms that underlie the development of the mandibular and the hyoid arches, as well as the process of cartilage differentiation.

Bibliography

Piotrowski, T., Schilling, T. F., Brand, M., Jiang, Y.-J., Heisenberg, C.-P., Beuchle, D., Grandel, H., Eeden, F. J. M. van, Furutani-Seiki, M., Granato, M., Haffter, P., Hammerschmidt, M., Kane, D. A., Kelsh, R. N., Mullins, M. C., Odenthal, J., Warga, R. M., & NÃ¼sslein-Volhard, C. (1996). Jaw and branchial arch mutants in zebrafish II: anterior arches and cartilage differentiation. Development, 123(1), 345â356.

Authors 18

Tatjana Piotrowski (first)
Thomas F. Schilling (additional)
Michael Brand (additional)
Yun-Jin Jiang (additional)
Carl-Philipp Heisenberg (additional)
Dirk Beuchle (additional)
Heiner Grandel (additional)
Fredericus J. M. van Eeden (additional)
Makoto Furutani-Seiki (additional)
Michael Granato (additional)
Pascal Haffter (additional)
Matthias Hammerschmidt (additional)
Donald A. Kane (additional)
Robert N. Kelsh (additional)
Mary C. Mullins (additional)
Jörg Odenthal (additional)
Rachel M. Warga (additional)
Christiane Nüsslein-Volhard (additional)

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Dates

Type	When
Created	4 years, 4 months ago (April 25, 2021, 10:50 p.m.)
Deposited	2 years, 1 month ago (July 28, 2023, 6:03 a.m.)
Indexed	1 month, 2 weeks ago (July 16, 2025, 9:13 a.m.)
Issued	28 years, 9 months ago (Dec. 1, 1996)
Published	28 years, 9 months ago (Dec. 1, 1996)
Published Online	28 years, 9 months ago (Dec. 1, 1996)
Published Print	28 years, 9 months ago (Dec. 1, 1996)

Funders 0

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BibTeX

@article{Piotrowski_1996, title={Jaw and branchial arch mutants in zebrafish II: anterior arches and cartilage differentiation}, volume={123}, ISSN={1477-9129}, url={http://dx.doi.org/10.1242/dev.123.1.345}, DOI={10.1242/dev.123.1.345}, number={1}, journal={Development}, publisher={The Company of Biologists}, author={Piotrowski, Tatjana and Schilling, Thomas F. and Brand, Michael and Jiang, Yun-Jin and Heisenberg, Carl-Philipp and Beuchle, Dirk and Grandel, Heiner and Eeden, Fredericus J. M. van and Furutani-Seiki, Makoto and Granato, Michael and Haffter, Pascal and Hammerschmidt, Matthias and Kane, Donald A. and Kelsh, Robert N. and Mullins, Mary C. and Odenthal, Jörg and Warga, Rachel M. and Nüsslein-Volhard, Christiane}, year={1996}, month=dec, pages={345–356} }

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  "abstract": "<jats:title>ABSTRACT</jats:title>\n               <jats:p>In a large scale screen for mutants that affect the early development of the zebrafish, 109 mutants were found that cause defects in the formation of the jaw and the more posterior pharyngeal arches. Here we present the phenotypic description and results of the complementation analysis of mutants belonging to two major classes: (1) mutants with defects in the mandibular and hyoid arches and (2) mutants with defects in cartilage differentiation and growth in all arches. Mutations in four of the genes identified during the screen show specific defects in the first two arches and leave the more posterior pharyngeal arches largely unaffected (schmerle, sucker, hoover and sturgeon). In these mutants ventral components of the mandibular and hyoid arches are reduced (Meckel\u2019s cartilage and ceratohyal cartilage) whereas dorsal structures (palatoquadrate and hyosymplectic cartilages) are of normal size or enlarged. Thus, mutations in single genes cause defects in the formation of first and second arch structures but also differentially affect development of the dorsal and ventral structures within one arch.</jats:p>\n               <jats:p>In 27 mutants that define at least 8 genes, the differentiation of cartilage and growth is affected. In hammerhead mutants particularly the mesodermally derived cartilages are reduced, whereas jellyfish mutant larvae are characterized by a severe reduction of all cartilaginous elements, leaving only two pieces in the position of the ceratohyal cartilages. In all other mutant larvae all skeletal elements are present, but consist of smaller and disorganized chondrocytes. These mutants also exhibit shortened heads and reduced pectoral fins. In homozygous knorrig embryos, tumor-like outgrowths of chondrocytes occur along the edges of all cartilaginous elements. The mutants presented here may be valuable tools for elucidating the genetic mechanisms that underlie the development of the mandibular and the hyoid arches, as well as the process of cartilage differentiation.</jats:p>",
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