DOI: 10.1242/dev.123.1.117. Mutations affecting development of the notochord in zebrafish

Mutations affecting development of the notochord in zebrafish

10.1242/dev.123.1.117

Crossref journal-article

The Company of Biologists

Development (237)

Abstract

ABSTRACT The notochord is critical for the normal development of vertebrate embryos. It serves both as the major skeletal element of the embryo and as a signaling source for the establishment of pattern within the neurectoderm, the paraxial mesoderm and other tissues. In a large-scale systematic screen of mutations affecting embryogenesis in zebrafish we identified 65 mutations that fall into 29 complementation groups, each leading to a defect in the formation and/or maintenance of the notochord. These mutations produce phenotypic abnormalities at numerous stages of notochord development, thereby establishing a phenotypic pathway, which in turn suggests a genetic pathway for the development of the notochord. Perturbations within adjacent tissues in mutant embryos further indicate the importance of notochord-derived signals for patterning within the embryo and suggest that these mutations will yield additional insight into the cues that regulate these patterning processes.

Bibliography

Stemple, D. L., Solnica-Krezel, L., Zwartkruis, F., Neuhauss, S. C. F., Schier, A. F., Malicki, J., Stainier, D. Y. R., Abdelilah, S., Rangini, Z., Mountcastle-Shah, E., & Driever, W. (1996). Mutations affecting development of the notochord in zebrafish. Development, 123(1), 117â128.

Authors 11

Derek L. Stemple (first)
Lilianna Solnica-Krezel (additional)
Fried Zwartkruis (additional)
Stephan C. F. Neuhauss (additional)
Alexander F. Schier (additional)
Jarema Malicki (additional)
Didier Y. R. Stainier (additional)
Salim Abdelilah (additional)
Zehava Rangini (additional)
Elizabeth Mountcastle-Shah (additional)
Wolfgang Driever (additional)

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Dates

Type	When
Created	4 years, 4 months ago (April 25, 2021, 10:50 p.m.)
Deposited	2 years ago (July 28, 2023, 6:05 a.m.)
Indexed	3 weeks ago (Aug. 6, 2025, 9:54 a.m.)
Issued	28 years, 8 months ago (Dec. 1, 1996)
Published	28 years, 8 months ago (Dec. 1, 1996)
Published Online	28 years, 8 months ago (Dec. 1, 1996)
Published Print	28 years, 8 months ago (Dec. 1, 1996)

Funders 0

None

BibTeX

@article{Stemple_1996, title={Mutations affecting development of the notochord in zebrafish}, volume={123}, ISSN={1477-9129}, url={http://dx.doi.org/10.1242/dev.123.1.117}, DOI={10.1242/dev.123.1.117}, number={1}, journal={Development}, publisher={The Company of Biologists}, author={Stemple, Derek L. and Solnica-Krezel, Lilianna and Zwartkruis, Fried and Neuhauss, Stephan C. F. and Schier, Alexander F. and Malicki, Jarema and Stainier, Didier Y. R. and Abdelilah, Salim and Rangini, Zehava and Mountcastle-Shah, Elizabeth and Driever, Wolfgang}, year={1996}, month=dec, pages={117–128} }

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