DOI: 10.1242/dev.122.4.1137. The SH2-containing tyrosine phosphatase corkscrew is required during signaling by sevenless, Ras1 and Raf

The SH2-containing tyrosine phosphatase corkscrew is required during signaling by sevenless, Ras1 and Raf

10.1242/dev.122.4.1137

Crossref journal-article

The Company of Biologists

Development (237)

Abstract

ABSTRACT The sevenless gene encodes a receptor tyrosine kinase which is required for the development of the R7 photoreceptor cell in each ommatidium of the Drosophila eye. We have previously used a sensitized genetic screen to identify mutations, designated Enhancers of sevenless (E(sev)), which affect genes that encode components of the sevenless signaling pathway. Here, we report that one of these mutations, E(sev)1Ae0P is a dominantly inhibiting allele of corkscrew, which encodes an SH2 domain-containing protein tyrosine phosphatase (Perkins et al., 1992). We show that corkscrew function is essential for sevenless signaling and that expression of a membrane-targeted form of corkscrew can drive R7 photoreceptor development in the absence of sevenless function. Furthermore, we have used the dominantly inhibiting corkscrew allele to examine the role of corkscrew during signaling by activated forms of Ras1 and Raf. Our analysis indicates that corkscrew function is still required during signaling by activated Ras1 and Raf proteins. These results define a function for corkscrew that is either downstream of Ras1 activation or in a parallel pathway that acts with activated Ras1/Raf to specify R7 photoreceptor development.

Bibliography

Allard, J. D., Chang, H. C., Herbst, R., McNeill, H., & Simon, M. A. (1996). The SH2-containing tyrosine phosphatase corkscrew is required during signaling by sevenless, Ras1 and Raf. Development, 122(4), 1137â1146.

Authors 5

John D. Allard (first)
Henry C. Chang (additional)
Ronald Herbst (additional)
Helen McNeill (additional)
Michael A. Simon (additional)

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Dates

Type	When
Created	4 years, 4 months ago (April 25, 2021, 10:38 p.m.)
Deposited	6 months, 2 weeks ago (Feb. 13, 2025, 5:43 p.m.)
Indexed	6 months, 2 weeks ago (Feb. 14, 2025, 12:32 a.m.)
Issued	29 years, 4 months ago (April 1, 1996)
Published	29 years, 4 months ago (April 1, 1996)
Published Online	29 years, 4 months ago (April 1, 1996)
Published Print	29 years, 4 months ago (April 1, 1996)

Funders 0

None

BibTeX

@article{Allard_1996, title={The SH2-containing tyrosine phosphatase corkscrew is required during signaling by sevenless, Ras1 and Raf}, volume={122}, ISSN={1477-9129}, url={http://dx.doi.org/10.1242/dev.122.4.1137}, DOI={10.1242/dev.122.4.1137}, number={4}, journal={Development}, publisher={The Company of Biologists}, author={Allard, John D. and Chang, Henry C. and Herbst, Ronald and McNeill, Helen and Simon, Michael A.}, year={1996}, month=apr, pages={1137–1146} }

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