DOI: 10.1242/dev.122.2.617. Autonomous and nonautonomous Notch functions for embryonic muscle and epidermis development in <i>Drosophila</i>

Autonomous and nonautonomous Notch functions for embryonic muscle and epidermis development in Drosophila

10.1242/dev.122.2.617

Crossref journal-article

The Company of Biologists

Development (237)

Abstract

ABSTRACT The Notch (N) gene encodes a cell signaling protein that mediates neuronal and epidermal determination in Drosophila embryos. N also regulates several aspects of myogenic development; embryos lacking N function have too many muscle founder cells and fail to properly differentiate somatic muscle. To identify cell-autonomous requirements for Notch function during muscle development, we expressed a Notch minigene in the mesoderm, but not in the ectoderm, of amorphic N− embryos. In these embryos, muscle founder hypertrophy is rescued, indicating that Notch is autonomously required by mesoderm cells to regulate the proper number of muscle founders. However, somatic muscle differentiation is only partially normalized, suggesting that Notch is also required in the ectoderm for proper muscle development. Additionally, mesodermal expression of Notch partially rescues epidermal development in overlying neurogenic ectoderm. This is unexpected, since previous studies suggest that Notch is autonomously required by proneural ectoderm cells for epidermal development. Mesodermal expression of a truncated Notch protein lacking the extracellular domain does not rescue ventral epidermis, suggesting that the extracellular domain of Notch can non-autonomously rescue epidermal development across germ layers.

Bibliography

Baker, R., & Schubiger, G. (1996). Autonomous and nonautonomous Notch functions for embryonic muscle and epidermis development in Drosophila. Development, 122(2), 617â626.

Authors 2

Rob Baker (first)
Gerold Schubiger (additional)

References 47 Referenced 51

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Dates

Type	When
Created	4 years, 4 months ago (April 23, 2021, 2:55 p.m.)
Deposited	6 months, 2 weeks ago (Feb. 13, 2025, 5:18 p.m.)
Indexed	6 months, 2 weeks ago (Feb. 14, 2025, 12:31 a.m.)
Issued	29 years, 7 months ago (Feb. 1, 1996)
Published	29 years, 7 months ago (Feb. 1, 1996)
Published Online	29 years, 7 months ago (Feb. 1, 1996)
Published Print	29 years, 7 months ago (Feb. 1, 1996)

Funders 0

None

BibTeX

@article{Baker_1996, title={Autonomous and nonautonomous Notch functions for embryonic muscle and epidermis development in Drosophila}, volume={122}, ISSN={1477-9129}, url={http://dx.doi.org/10.1242/dev.122.2.617}, DOI={10.1242/dev.122.2.617}, number={2}, journal={Development}, publisher={The Company of Biologists}, author={Baker, Rob and Schubiger, Gerold}, year={1996}, month=feb, pages={617–626} }

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