DOI: 10.1242/dev.122.12.4149. <i>cdh-3</i>, a gene encoding a member of the cadherin superfamily, functions in epithelial cell morphogenesis in <i>Caenorhabditis elegans</i>

cdh-3, a gene encoding a member of the cadherin superfamily, functions in epithelial cell morphogenesis in Caenorhabditis elegans

10.1242/dev.122.12.4149

Crossref journal-article

The Company of Biologists

Development (237)

Abstract

ABSTRACT Several genes that encode members of the cadherin super-family have been identified in Caenorhabditis elegans. Based on the roles of cadherins in vertebrates and Drosophila, it is expected that they function in the control of epithelial morphogenesis, an event which is poorly understood at the molecular level in C. elegans. Reporter genes under the control of upstream sequences from one of these genes, cdh-3, are expressed in developing epithelial cells, but also in a number of neuroectodermal cells that extend processes along some of these epithelial cells. We generated a loss-of-function mutation in cdh-3 by transposon-mediated deletion mutagenesis. This mutation affects the morphogenesis of a single cell, hyp10, which forms the tip of the nematode tail. The lack of detectable defects associated with the other cells expressing cdh-3 reporter constructs hints at the existence of other genes that can compensate for cdh-3 loss of function.

Bibliography

Pettitt, J., Wood, W. B., & Plasterk, R. H. A. (1996). cdh-3, a gene encoding a member of the cadherin superfamily, functions in epithelial cell morphogenesis in Caenorhabditis elegans. Development, 122(12), 4149â4157.

Authors 3

Jonathan Pettitt (first)
William B. Wood (additional)
Ronald H. A. Plasterk (additional)

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Dates

Type	When
Created	4 years, 4 months ago (April 25, 2021, 10:41 p.m.)
Deposited	6 months, 2 weeks ago (Feb. 13, 2025, 7 p.m.)
Indexed	4 months, 2 weeks ago (April 17, 2025, 6:48 a.m.)
Issued	28 years, 9 months ago (Dec. 1, 1996)
Published	28 years, 9 months ago (Dec. 1, 1996)
Published Online	28 years, 9 months ago (Dec. 1, 1996)
Published Print	28 years, 9 months ago (Dec. 1, 1996)

Funders 0

None

BibTeX

@article{Pettitt_1996, title={cdh-3, a gene encoding a member of the cadherin superfamily, functions in epithelial cell morphogenesis in Caenorhabditis elegans}, volume={122}, ISSN={1477-9129}, url={http://dx.doi.org/10.1242/dev.122.12.4149}, DOI={10.1242/dev.122.12.4149}, number={12}, journal={Development}, publisher={The Company of Biologists}, author={Pettitt, Jonathan and Wood, William B. and Plasterk, Ronald H. A.}, year={1996}, month=dec, pages={4149–4157} }

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