DOI: 10.1242/dev.122.1.97. The <i>C. elegans</i> vulval induction gene <i>lin-2</i> encodes a member of the MAGUK family of cell junction proteins

The C. elegans vulval induction gene lin-2 encodes a member of the MAGUK family of cell junction proteins

10.1242/dev.122.1.97

Crossref journal-article

The Company of Biologists

Development (237)

Abstract

ABSTRACT The lin-2 gene is required for the induction of the Caenorhabditis elegans vulva. Vulval development is initiated by a signal from the anchor cell that is transduced by a receptor tyrosine kinase/Ras pathway. We show that lin-2 acts in the vulval precursor cell P6.p, downstream of lin-3 EGF and upstream of let-60 ras, to allow expression of the 1° cell fate. lin-2 encodes a protein of relative molecular mass 109,000 (LIN-2A) with regions of similar-ity to CaM kinase II and membrane-associated guanylate kinases. Mutant lin-2 transgenes designed to lack either protein kinase or guanylate kinase activity are functional, indicating that LIN-2A has a structural rather than an enzymatic role in vulval induction. Most or all identified membrane-associated guanylate kinases are components of cell junctions, including vertebrate tight junctions and arthropod septate junctions in epithelia. Thus, LIN-2A may be a component of the cell junctions of the epithelial vulval precursor cells that is required for signaling by the receptor tyrosine kinase LET-23. We propose that LIN-2A is required for the localization of one or more signal trans-duction proteins (such as LET-23) to either the basal membrane domain or the cell junctions, and that mislocal-ization of signal transduction proteins in lin-2 mutants interferes with vulval induction.

Bibliography

Hoskins, R., Hajnal, A. F., Harp, S. A., & Kim, S. K. (1996). The C. elegans vulval induction gene lin-2 encodes a member of the MAGUK family of cell junction proteins. Development, 122(1), 97â111.

Authors 4

Roger Hoskins (first)
Alex F. Hajnal (additional)
Stacey A. Harp (additional)
Stuart K. Kim (additional)

References 77 Referenced 167

10.1016/0925-4773(92)90014-B / Mech. Dev / Epithelial polarity and cell separation in the neoplastic l(1)dlg-1 mutant of Drosophila by Abbott (1992)
10.1038/348693a0 / Nature / The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily by Aroian (1990)
10.1093/genetics/128.2.251 / Genetics / Multiple functions of let-23, a Caenorhabditis elegans receptor tyrosine kinase gene required for vulval induction by Aroian (1991)
10.1016/0092-8674(87)90020-1 / Cell / The sevenless+ protein is expressed apically in cell membranes of developing Drosophila retina; it is not restricted to cell R7 by Banerjee (1987)
10.1038/348503a0 / Nature / Caenorhabditis elegans ras gene let-60 acts as a switch in the pathway of vulval induction by Beitel (1990)
10.1093/genetics/77.1.71 / Genetics / The genetics of Caenorhabditis elegans by Brenner (1974)
10.1016/0165-0173(93)90011-N / Brain Res. Rev / Regulation of type-II calmodulin kinase: functional implications by Bronstein (1993)
10.1016/0896-6273(92)90245-9 / Neuron / The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein by Cho (1992)
10.1126/science.1379745 / Science / Identification of a protein that binds to the SH3 region of Abl and is similar to Bcr and GAP-rho by Cicchetti (1992)
10.1083/jcb.125.2.313 / J. Cell Biol / Targeting of the SF/HGF receptor to the basolateral domain of polarized epithelial cells by Crepaldi (1994)
10.1038/335184a0 / Nature / Genome linking with yeast artificial chromosomes by Coulson (1988)
10.1093/hmg/3.6.909 / Hum. Mol. Genet / The Friedrich ataxia region: characterization of two novel genes and reduction of the critical region to 300 kb by Duclos (1994)
10.1016/0959-437X(94)90065-B / Curr. Opin. Genet. Dev / Signal transduction and cell fate specification during Caenorhabditis elegans vulval development by Eisenmann (1994)
10.1083/jcb.113.3.657 / J. Cell Biol / Complex cellular and subcellular regulation of Notch expression during embryonic and imaginal development of Drosophila: implications for Notch function by Fehon (1991)
10.1093/genetics/110.1.17 / Genetics / Identification and characterization of 22 genes that affect the vulval cell lineages of the nematode Caenorhabditis elegans by Ferguson (1985)
10.1002/j.1460-2075.1986.tb04550.x / EMBO J / Integrative transformation of Caenorhabditis elegans by Fire (1986)
10.1083/jcb.114.3.465 / J. Cell Biol / Muscle cell attachment in Caenorhabditis elegans by Francis (1991)
10.1083/jcb.127.6.1617 / J. Cell Biol / Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions by Furuse (1994)
10.1016/S0021-9258(18)31532-1 / J. Biol. Chem / Rational scanning mutagenesis of a protein kinase identifies functional regions involved in catalysis and substrate interactions by Gibbs (1991)
10.1073/pnas.88.8.3460 / Proc. Natl. Acad. Sci. USA / Identification of a 160-kDa polypeptide that binds to the tight junction protein ZO-1 by Gumbiner (1991)
10.1093/genetics/126.4.899 / Genetics / The let-60 locus controls the switch between vulval and nonvulval cell fates in Caenorhabditis elegans by Han (1990)
10.1016/0092-8674(90)90495-Z / Cell / let-60, a gene that specifies cell fates during C. elegans vulval induction, encodes a ras protein by Han (1990)
10.1126/science.3291115 / Science / The protein kinase family: conserved features and deduced phylogeny of the catalytic domains by Hanks (1988)
{'key': '2025021322400564900_DEVELOP_122_1_97C24', 'first-page': '17', 'article-title': 'Genetics', 'volume-title': 'In The Nematode Caenorhabditis elegans', 'author': 'Herman', 'year': '1988'} / In The Nematode Caenorhabditis elegans / Genetics by Herman (1988)
10.1038/348169a0 / Nature / Limitation of the size of the vulval primordium of Caenorhabditis elegans by lin-15 expression in surrounding hypodermis by Herman (1990)
10.1038/358470a0 / Nature / The gene lin-3 encodes an inductive signal for vulval development in C. elegans by Hill (1992)
10.1038/351535a0 / Nature / Multiple intercellular signalling systems control the development of the C. elegans vulva by Horvitz (1991)
10.1093/genetics/96.2.435 / Genetics / Isolation and genetic characterization of cell-lineage mutants of the nematode Caenorhabditis elegans by Horvitz (1980)
10.1083/jcb.124.6.949 / J. Cell Biol / Molecular characterization and tissue distribution of ZO-2, a tight junction protein homologous to ZO-1 and the Drosophila discs-large tumor suppressor protein by Jesaitis (1994)
10.1016/0092-8674(95)90317-8 / Cell / Different levels of the C. elegans growth factor LIN-3 promote distinct vulval precursor fates by Katz (1995)
10.1101/gad.4.3.357 / Genes Dev / The Caenorhabditis elegans gene lin-10 is broadly expressed while required specifically for the determination of vulval cell fates by Kim (1990)
10.1016/0012-1606(81)90152-4 / Dev. Biol / Alterations in cell lineage following laser ablation of cells in the somatic gonad of Caenorhabditis elegans by Kimble (1981)
10.1016/S0021-9258(18)53433-5 / J. Biol. Chem / SAP90, a rat presynaptic protein related to the product of the Drosophila tumor suppressor gene dlg-A by Kistner (1993)
10.1242/dev.121.8.2655 / Development / Mosaic analysis of the let-23 gene function in vulval induction of Caenorhabditis elegans by Koga (1995)
10.1126/science.7569905 / Science / Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95 by Kornau (1995)
10.1101/gad.9.6.756 / Genes Dev / The Caenorhabditis elegans gene mek-2 is required for vulval induction and encodes a protein similar to the protein kinase MEK by Kornfeld (1995)
{'key': '2025021322400564900_DEVELOP_122_1_97C37', 'first-page': 'F514', 'article-title': 'Increased Tyr phosphorylation of ZO-1 during modification of tight junctions between glomerular foot processes', 'volume-title': 'Am. J. Physiol', 'author': 'Kurihara', 'year': '1995'} / Am. J. Physiol / Increased Tyr phosphorylation of ZO-1 during modification of tight junctions between glomerular foot processes by Kurihara (1995)
10.1101/gad.8.2.160 / Genes Dev / A MAP kinase homolog, mpk-1, is involved in ras-mediated induction of vulval cell fates in Caenorhabditis elegans by Lackner (1994)
10.1073/pnas.84.16.5962 / Proc. Natl. Acad. Sci. USA / Molecular cloning of a brain-specific calcium/calmodulin-dependent protein kinase by Lin (1987)
10.1073/pnas.91.21.9818 / Proc. Natl. Acad. Sci. USA / Cloning and characterization of hdlg: the human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1 by Lue (1994)
10.1083/jcb.105.4.1595 / J. Cell Biol / Receptor-mediated vectorial transcytosis of epidermal growth factor by Madin-Darby canine kidney cells by Maratos-Flier (1987)
10.1016/S0021-9258(17)37012-6 / J. Biol. Chem / In vitro binding studies suggest a membrane-associated complex between erythroid p55, protein 4.1, and glycophoran C by Marfatia (1994)
10.1002/j.1460-2075.1991.tb04966.x / EMBO J / Efficient gene transfer in C. elegans: extrachromosomal maintenance and integration of transforming sequences by Mello (1991)
10.1101/gad.7.6.933 / Genes Dev / lin-31, a Caenorhabditis elegans HNF-3/fork head transcription factor homolog, specifies three alternative cell fates in vulval development by Miller (1993)
10.1523/JNEUROSCI.15-03-02354.1995 / J. Neurosci / Molecular characterization and spatial distribution of SAP97, a novel presynaptic protein homologous to SAP90 and the Drosophila discs-large tumor suppressor protein by Müller (1995)
{'key': '2025021322400564900_DEVELOP_122_1_97C46', 'first-page': '4886', 'article-title': 'Epidermal growth factor-induced mitogenesis in kidney epithelial cells (LLC-PK1)', 'volume': '48', 'author': 'Mullin', 'year': '1987', 'journal-title': 'Cancer Res'} / Cancer Res / Epidermal growth factor-induced mitogenesis in kidney epithelial cells (LLC-PK1) by Mullin (1987)
10.1016/0079-6107(94)90003-5 / Prog. Biophys. Molec. Biol / Structure and function of the SH3 domain by Musacchio (1994)
10.1016/S0968-0004(00)88973-2 / Trends Biochem. Sci / DHR domains in syntrophins, neuronal NO synthases and other intracellular proteins by Ponting (1995)
10.1126/science.8438166 / Science / Identification of a ten-amino acid proline-rich SH3 binding site by Ren (1993)
10.1073/pnas.88.15.6595 / Proc. Natl. Acad. Sci. USA / Molecular identification of a major palmitoylated erythrocyte membrane protein containing the src homology 3 motif by Ruff (1991)
10.1126/science.7536343 / Science / FAP-1: a protein tyrosine phosphatase that associates with Fas by Sato (1995)
{'key': '2025021322400564900_DEVELOP_122_1_97C52', 'volume-title': 'Molecular Cloning', 'author': 'Sambrook', 'year': '1989', 'edition': '2nd'} / Molecular Cloning by Sambrook (1989)
10.1007/BF00966924 / Neurochem. Res / Multifunctional Ca2+/calmodulin-dependent protein kinase by Schulman (1993)
10.1038/375142a0 / Nature / Sequential signalling during Caenorhabditis elegans vulval induction by Simske (1995)
10.1016/0378-1119(86)90117-4 / Gene / Kanamycin-resistant vectors that are analogues of plasmids pUC8, pUC9, pEMBL8 and pEMBL9 by Spratt (1986)
10.1016/0022-2836(92)90474-X / J. Mol. Biol / Refined structure of the complex between guanylate kinase and its substrate GMP at 2.0 Å resolution by Stehle (1992)
10.1038/335551a0 / Nature / Lateral inhibition during vulval induction in Caenorhabditis elegans by Sternberg (1988)
10.1016/0092-8674(86)90842-1 / Cell / Pattern formation during vulval development in C. elegans by Sternberg (1986)
10.1016/0092-8674(89)90103-7 / Cell / The combined action of two intercellular signaling pathways specifies three cell fates during vulval induction in C. elegans by Sternberg (1989)
10.1083/jcb.103.3.755 / J. Cell Biol / Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia by Stevenson (1986)
10.1016/0012-1606(72)90113-3 / Dev. Biol / The recovery and preliminary characterization of X chromosome mutants affecting imaginal discs of Drosophila melanogaster by Stewart (1972)
10.1093/genetics/77.1.95 / Genetics / The DNA of Caenorhabditis elegans by Sulston (1974)
10.1016/0012-1606(77)90158-0 / Dev. Biol / Post-embryonic cell lineages of the nematode Caenorhabditis elegans by Sulston (1977)
10.1016/0012-1606(83)90201-4 / Dev. Biol / The embryonic cell lineage of the nematode Caenorhabditis elegans by Sulston (1983)
10.1146/annurev.cb.08.110192.002241 / Annu. Rev. Cell Biol / Structural framework for the protein kinase family by Taylor (1992)
10.1016/0092-8674(90)90382-O / Cell / Cell interactions coordinate the development of the C. elegans egg-laying system by Thomas (1990)
10.1016/0092-8674(87)90019-5 / Cell / Localization of the sevenless protein, a putative receptor for positional information, in the eye imaginal disc of Drosophila by Tomlinson (1987)
{'key': '2025021322400564900_DEVELOP_122_1_97C68', 'first-page': '1735', 'article-title': 'Epidermal growth factor induces tyrosine phosphorylation and reorganization of the tight junction protein ZO-1 in A431 cells', 'volume-title': 'J. Cell Sci', 'author': 'van Itallie', 'year': '1995'} / J. Cell Sci / Epidermal growth factor induces tyrosine phosphorylation and reorganization of the tight junction protein ZO-1 in A431 cells by van Itallie (1995)
{'key': '2025021322400564900_DEVELOP_122_1_97C69', 'first-page': '81', 'article-title': 'The anatomy', 'volume-title': 'In The Nematode Caenorhabditis elegans', 'author': 'White', 'year': '1988'} / In The Nematode Caenorhabditis elegans / The anatomy by White (1988)
10.1073/pnas.90.16.7834 / Proc. Natl. Acad. Sci. USA / The tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppressor protein of septate junctions by Willott (1993)
10.1038/368032a0 / Nature / 2.2 mb of contiguous nucleotide sequence from chromosome III of C. elegans by Wilson (1994)
{'volume-title': 'The Nematode Caenorhabditis elegans', 'year': '1988', 'author': 'Wood', 'key': '2025021322400564900_DEVELOP_122_1_97C72'} / The Nematode Caenorhabditis elegans by Wood (1988)
10.1016/0012-1606(89)90092-4 / Dev. Biol / Molecular cloning of the lethal(1)discs large-1 oncogene of Drosophila by Woods (1989)
10.1016/0092-8674(81)90009-X / Cell / The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions by Woods (1991)
10.1016/0925-4773(93)90059-7 / Mech. Dev / ZO-1, DlgA and PSD-95/SAP90: homologous proteins in tight, septate and synaptic cell junctions by Woods (1993)
10.1101/gad.9.6.742 / Genes Dev / MEK-2, a Caenorhabditis elegans MAP kinase kinase, functions in Ras-mediated vulval induction and other developmental events by Wu (1995)
10.1016/0012-1606(92)90299-V / Dev. Biol / Localization of DER and the pattern of cell divisions in wild-type and Ellipse eye imaginal discs by Zak (1992)

Dates

Type	When
Created	4 years, 4 months ago (April 25, 2021, 10:30 p.m.)
Deposited	6 months, 3 weeks ago (Feb. 13, 2025, 5:40 p.m.)
Indexed	2 months, 1 week ago (June 26, 2025, 2:05 p.m.)
Issued	29 years, 8 months ago (Jan. 1, 1996)
Published	29 years, 8 months ago (Jan. 1, 1996)
Published Online	29 years, 8 months ago (Jan. 1, 1996)
Published Print	29 years, 8 months ago (Jan. 1, 1996)

Funders 0

None

BibTeX

@article{Hoskins_1996, title={The C. elegans vulval induction gene lin-2 encodes a member of the MAGUK family of cell junction proteins}, volume={122}, ISSN={1477-9129}, url={http://dx.doi.org/10.1242/dev.122.1.97}, DOI={10.1242/dev.122.1.97}, number={1}, journal={Development}, publisher={The Company of Biologists}, author={Hoskins, Roger and Hajnal, Alex F. and Harp, Stacey A. and Kim, Stuart K.}, year={1996}, month=jan, pages={97–111} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        6,
        26
      ]
    ],
    "date-time": "2025-06-26T18:05:55Z",
    "timestamp": 1750961155815,
    "version": "3.37.0"
  },
  "reference-count": 77,
  "publisher": "The Company of Biologists",
  "issue": "1",
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1996,
        1,
        1
      ]
    ]
  },
  "abstract": "<jats:title>ABSTRACT</jats:title>\n               <jats:p>The lin-2 gene is required for the induction of the Caenorhabditis elegans vulva. Vulval development is initiated by a signal from the anchor cell that is transduced by a receptor tyrosine kinase/Ras pathway. We show that lin-2 acts in the vulval precursor cell P6.p, downstream of lin-3 EGF and upstream of let-60 ras, to allow expression of the 1\u00b0 cell fate. lin-2 encodes a protein of relative molecular mass 109,000 (LIN-2A) with regions of similar-ity to CaM kinase II and membrane-associated guanylate kinases. Mutant lin-2 transgenes designed to lack either protein kinase or guanylate kinase activity are functional, indicating that LIN-2A has a structural rather than an enzymatic role in vulval induction. Most or all identified membrane-associated guanylate kinases are components of cell junctions, including vertebrate tight junctions and arthropod septate junctions in epithelia. Thus, LIN-2A may be a component of the cell junctions of the epithelial vulval precursor cells that is required for signaling by the receptor tyrosine kinase LET-23. We propose that LIN-2A is required for the localization of one or more signal trans-duction proteins (such as LET-23) to either the basal membrane domain or the cell junctions, and that mislocal-ization of signal transduction proteins in lin-2 mutants interferes with vulval induction.</jats:p>",
  "DOI": "10.1242/dev.122.1.97",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2021,
        4,
        26
      ]
    ],
    "date-time": "2021-04-26T02:30:43Z",
    "timestamp": 1619404243000
  },
  "page": "97-111",
  "source": "Crossref",
  "is-referenced-by-count": 167,
  "title": "The <i>C. elegans</i> vulval induction gene <i>lin-2</i> encodes a member of the MAGUK family of cell junction proteins",
  "prefix": "10.1242",
  "volume": "122",
  "author": [
    {
      "given": "Roger",
      "family": "Hoskins",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Department of Developmental Biology, Stanford University Medical School, Stanford, CA 94305, USA"
        }
      ]
    },
    {
      "given": "Alex F.",
      "family": "Hajnal",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Developmental Biology, Stanford University Medical School, Stanford, CA 94305, USA"
        }
      ]
    },
    {
      "given": "Stacey A.",
      "family": "Harp",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Developmental Biology, Stanford University Medical School, Stanford, CA 94305, USA"
        }
      ]
    },
    {
      "given": "Stuart K.",
      "family": "Kim",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Developmental Biology, Stanford University Medical School, Stanford, CA 94305, USA"
        }
      ]
    }
  ],
  "member": "237",
  "published-online": {
    "date-parts": [
      [
        1996,
        1,
        1
      ]
    ]
  },
  "reference": [
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C1",
      "doi-asserted-by": "crossref",
      "first-page": "43",
      "DOI": "10.1016/0925-4773(92)90014-B",
      "article-title": "Epithelial polarity and cell separation in the neoplastic l(1)dlg-1 mutant of Drosophila",
      "volume": "37",
      "author": "Abbott",
      "year": "1992",
      "journal-title": "Mech. Dev"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C2",
      "doi-asserted-by": "crossref",
      "first-page": "693",
      "DOI": "10.1038/348693a0",
      "article-title": "The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily",
      "volume": "348",
      "author": "Aroian",
      "year": "1990",
      "journal-title": "Nature"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C3",
      "doi-asserted-by": "crossref",
      "first-page": "251",
      "DOI": "10.1093/genetics/128.2.251",
      "article-title": "Multiple functions of let-23, a Caenorhabditis elegans receptor tyrosine kinase gene required for vulval induction",
      "volume": "128",
      "author": "Aroian",
      "year": "1991",
      "journal-title": "Genetics"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C4",
      "doi-asserted-by": "crossref",
      "first-page": "151",
      "DOI": "10.1016/0092-8674(87)90020-1",
      "article-title": "The sevenless+ protein is expressed apically in cell membranes of developing Drosophila retina; it is not restricted to cell R7",
      "volume": "51",
      "author": "Banerjee",
      "year": "1987",
      "journal-title": "Cell"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C5",
      "doi-asserted-by": "crossref",
      "first-page": "503",
      "DOI": "10.1038/348503a0",
      "article-title": "Caenorhabditis elegans ras gene let-60 acts as a switch in the pathway of vulval induction",
      "volume": "348",
      "author": "Beitel",
      "year": "1990",
      "journal-title": "Nature"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C6",
      "doi-asserted-by": "crossref",
      "first-page": "71",
      "DOI": "10.1093/genetics/77.1.71",
      "article-title": "The genetics of Caenorhabditis elegans",
      "volume": "77",
      "author": "Brenner",
      "year": "1974",
      "journal-title": "Genetics"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C7",
      "doi-asserted-by": "crossref",
      "first-page": "135",
      "DOI": "10.1016/0165-0173(93)90011-N",
      "article-title": "Regulation of type-II calmodulin kinase: functional implications",
      "volume": "18",
      "author": "Bronstein",
      "year": "1993",
      "journal-title": "Brain Res. Rev"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C8",
      "doi-asserted-by": "crossref",
      "first-page": "929",
      "DOI": "10.1016/0896-6273(92)90245-9",
      "article-title": "The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein",
      "volume": "9",
      "author": "Cho",
      "year": "1992",
      "journal-title": "Neuron"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C9",
      "doi-asserted-by": "crossref",
      "first-page": "803",
      "DOI": "10.1126/science.1379745",
      "article-title": "Identification of a protein that binds to the SH3 region of Abl and is similar to Bcr and GAP-rho",
      "volume": "257",
      "author": "Cicchetti",
      "year": "1992",
      "journal-title": "Science"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C10",
      "doi-asserted-by": "crossref",
      "first-page": "313",
      "DOI": "10.1083/jcb.125.2.313",
      "article-title": "Targeting of the SF/HGF receptor to the basolateral domain of polarized epithelial cells",
      "volume": "125",
      "author": "Crepaldi",
      "year": "1994",
      "journal-title": "J. Cell Biol"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C11",
      "doi-asserted-by": "crossref",
      "first-page": "184",
      "DOI": "10.1038/335184a0",
      "article-title": "Genome linking with yeast artificial chromosomes",
      "volume": "335",
      "author": "Coulson",
      "year": "1988",
      "journal-title": "Nature"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C12",
      "doi-asserted-by": "crossref",
      "first-page": "909",
      "DOI": "10.1093/hmg/3.6.909",
      "article-title": "The Friedrich ataxia region: characterization of two novel genes and reduction of the critical region to 300 kb",
      "volume": "3",
      "author": "Duclos",
      "year": "1994",
      "journal-title": "Hum. Mol. Genet"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C13",
      "doi-asserted-by": "crossref",
      "first-page": "508",
      "DOI": "10.1016/0959-437X(94)90065-B",
      "article-title": "Signal transduction and cell fate specification during Caenorhabditis elegans vulval development",
      "volume": "4",
      "author": "Eisenmann",
      "year": "1994",
      "journal-title": "Curr. Opin. Genet. Dev"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C14",
      "doi-asserted-by": "crossref",
      "first-page": "657",
      "DOI": "10.1083/jcb.113.3.657",
      "article-title": "Complex cellular and subcellular regulation of Notch expression during embryonic and imaginal development of Drosophila: implications for Notch function",
      "volume": "113",
      "author": "Fehon",
      "year": "1991",
      "journal-title": "J. Cell Biol"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C15",
      "doi-asserted-by": "crossref",
      "first-page": "17",
      "DOI": "10.1093/genetics/110.1.17",
      "article-title": "Identification and characterization of 22 genes that affect the vulval cell lineages of the nematode Caenorhabditis elegans",
      "volume": "110",
      "author": "Ferguson",
      "year": "1985",
      "journal-title": "Genetics"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C16",
      "doi-asserted-by": "crossref",
      "first-page": "2673",
      "DOI": "10.1002/j.1460-2075.1986.tb04550.x",
      "article-title": "Integrative transformation of Caenorhabditis elegans",
      "volume": "5",
      "author": "Fire",
      "year": "1986",
      "journal-title": "EMBO J"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C17",
      "doi-asserted-by": "crossref",
      "first-page": "465",
      "DOI": "10.1083/jcb.114.3.465",
      "article-title": "Muscle cell attachment in Caenorhabditis elegans",
      "volume": "114",
      "author": "Francis",
      "year": "1991",
      "journal-title": "J. Cell Biol"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C18",
      "doi-asserted-by": "crossref",
      "first-page": "1617",
      "DOI": "10.1083/jcb.127.6.1617",
      "article-title": "Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions",
      "volume": "127",
      "author": "Furuse",
      "year": "1994",
      "journal-title": "J. Cell Biol"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C19",
      "doi-asserted-by": "crossref",
      "first-page": "8923",
      "DOI": "10.1016/S0021-9258(18)31532-1",
      "article-title": "Rational scanning mutagenesis of a protein kinase identifies functional regions involved in catalysis and substrate interactions",
      "volume": "266",
      "author": "Gibbs",
      "year": "1991",
      "journal-title": "J. Biol. Chem"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C20",
      "doi-asserted-by": "crossref",
      "first-page": "3460",
      "DOI": "10.1073/pnas.88.8.3460",
      "article-title": "Identification of a 160-kDa polypeptide that binds to the tight junction protein ZO-1",
      "volume": "88",
      "author": "Gumbiner",
      "year": "1991",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C21",
      "doi-asserted-by": "crossref",
      "first-page": "899",
      "DOI": "10.1093/genetics/126.4.899",
      "article-title": "The let-60 locus controls the switch between vulval and nonvulval cell fates in Caenorhabditis elegans",
      "volume": "126",
      "author": "Han",
      "year": "1990",
      "journal-title": "Genetics"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C22",
      "doi-asserted-by": "crossref",
      "first-page": "921",
      "DOI": "10.1016/0092-8674(90)90495-Z",
      "article-title": "let-60, a gene that specifies cell fates during C. elegans vulval induction, encodes a ras protein",
      "volume": "63",
      "author": "Han",
      "year": "1990",
      "journal-title": "Cell"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C23",
      "doi-asserted-by": "crossref",
      "first-page": "42",
      "DOI": "10.1126/science.3291115",
      "article-title": "The protein kinase family: conserved features and deduced phylogeny of the catalytic domains",
      "volume": "241",
      "author": "Hanks",
      "year": "1988",
      "journal-title": "Science"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C24",
      "first-page": "17",
      "article-title": "Genetics",
      "volume-title": "In The Nematode Caenorhabditis elegans",
      "author": "Herman",
      "year": "1988"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C25",
      "doi-asserted-by": "crossref",
      "first-page": "169",
      "DOI": "10.1038/348169a0",
      "article-title": "Limitation of the size of the vulval primordium of Caenorhabditis elegans by lin-15 expression in surrounding hypodermis",
      "volume": "348",
      "author": "Herman",
      "year": "1990",
      "journal-title": "Nature"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C26",
      "doi-asserted-by": "crossref",
      "first-page": "470",
      "DOI": "10.1038/358470a0",
      "article-title": "The gene lin-3 encodes an inductive signal for vulval development in C. elegans",
      "volume": "358",
      "author": "Hill",
      "year": "1992",
      "journal-title": "Nature"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C27",
      "doi-asserted-by": "crossref",
      "first-page": "535",
      "DOI": "10.1038/351535a0",
      "article-title": "Multiple intercellular signalling systems control the development of the C. elegans vulva",
      "volume": "351",
      "author": "Horvitz",
      "year": "1991",
      "journal-title": "Nature"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C28",
      "doi-asserted-by": "crossref",
      "first-page": "435",
      "DOI": "10.1093/genetics/96.2.435",
      "article-title": "Isolation and genetic characterization of cell-lineage mutants of the nematode Caenorhabditis elegans",
      "volume": "96",
      "author": "Horvitz",
      "year": "1980",
      "journal-title": "Genetics"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C29",
      "doi-asserted-by": "crossref",
      "first-page": "949",
      "DOI": "10.1083/jcb.124.6.949",
      "article-title": "Molecular characterization and tissue distribution of ZO-2, a tight junction protein homologous to ZO-1 and the Drosophila discs-large tumor suppressor protein",
      "volume": "124",
      "author": "Jesaitis",
      "year": "1994",
      "journal-title": "J. Cell Biol"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C30",
      "doi-asserted-by": "crossref",
      "first-page": "297",
      "DOI": "10.1016/0092-8674(95)90317-8",
      "article-title": "Different levels of the C. elegans growth factor LIN-3 promote distinct vulval precursor fates",
      "volume": "82",
      "author": "Katz",
      "year": "1995",
      "journal-title": "Cell"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C31",
      "doi-asserted-by": "crossref",
      "first-page": "357",
      "DOI": "10.1101/gad.4.3.357",
      "article-title": "The Caenorhabditis elegans gene lin-10 is broadly expressed while required specifically for the determination of vulval cell fates",
      "volume": "4",
      "author": "Kim",
      "year": "1990",
      "journal-title": "Genes Dev"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C32",
      "doi-asserted-by": "crossref",
      "first-page": "286",
      "DOI": "10.1016/0012-1606(81)90152-4",
      "article-title": "Alterations in cell lineage following laser ablation of cells in the somatic gonad of Caenorhabditis elegans",
      "volume": "87",
      "author": "Kimble",
      "year": "1981",
      "journal-title": "Dev. Biol"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C33",
      "doi-asserted-by": "crossref",
      "first-page": "4580",
      "DOI": "10.1016/S0021-9258(18)53433-5",
      "article-title": "SAP90, a rat presynaptic protein related to the product of the Drosophila tumor suppressor gene dlg-A",
      "volume": "268",
      "author": "Kistner",
      "year": "1993",
      "journal-title": "J. Biol. Chem"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C34",
      "doi-asserted-by": "crossref",
      "first-page": "2655",
      "DOI": "10.1242/dev.121.8.2655",
      "article-title": "Mosaic analysis of the let-23 gene function in vulval induction of Caenorhabditis elegans",
      "volume": "121",
      "author": "Koga",
      "year": "1995",
      "journal-title": "Development"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C35",
      "doi-asserted-by": "crossref",
      "first-page": "1737",
      "DOI": "10.1126/science.7569905",
      "article-title": "Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95",
      "volume": "269",
      "author": "Kornau",
      "year": "1995",
      "journal-title": "Science"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C36",
      "doi-asserted-by": "crossref",
      "first-page": "756",
      "DOI": "10.1101/gad.9.6.756",
      "article-title": "The Caenorhabditis elegans gene mek-2 is required for vulval induction and encodes a protein similar to the protein kinase MEK",
      "volume": "9",
      "author": "Kornfeld",
      "year": "1995",
      "journal-title": "Genes Dev"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C37",
      "first-page": "F514",
      "article-title": "Increased Tyr phosphorylation of ZO-1 during modification of tight junctions between glomerular foot processes",
      "volume-title": "Am. J. Physiol",
      "author": "Kurihara",
      "year": "1995"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C38",
      "doi-asserted-by": "crossref",
      "first-page": "160",
      "DOI": "10.1101/gad.8.2.160",
      "article-title": "A MAP kinase homolog, mpk-1, is involved in ras-mediated induction of vulval cell fates in Caenorhabditis elegans",
      "volume": "8",
      "author": "Lackner",
      "year": "1994",
      "journal-title": "Genes Dev"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C39",
      "doi-asserted-by": "crossref",
      "first-page": "5962",
      "DOI": "10.1073/pnas.84.16.5962",
      "article-title": "Molecular cloning of a brain-specific calcium/calmodulin-dependent protein kinase",
      "volume": "84",
      "author": "Lin",
      "year": "1987",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C40",
      "doi-asserted-by": "crossref",
      "first-page": "9818",
      "DOI": "10.1073/pnas.91.21.9818",
      "article-title": "Cloning and characterization of hdlg: the human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1",
      "volume": "91",
      "author": "Lue",
      "year": "1994",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C41",
      "doi-asserted-by": "crossref",
      "first-page": "1595",
      "DOI": "10.1083/jcb.105.4.1595",
      "article-title": "Receptor-mediated vectorial transcytosis of epidermal growth factor by Madin-Darby canine kidney cells",
      "volume": "105",
      "author": "Maratos-Flier",
      "year": "1987",
      "journal-title": "J. Cell Biol"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C42",
      "doi-asserted-by": "crossref",
      "first-page": "8631",
      "DOI": "10.1016/S0021-9258(17)37012-6",
      "article-title": "In vitro binding studies suggest a membrane-associated complex between erythroid p55, protein 4.1, and glycophoran C",
      "volume": "269",
      "author": "Marfatia",
      "year": "1994",
      "journal-title": "J. Biol. Chem"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C43",
      "doi-asserted-by": "crossref",
      "first-page": "3959",
      "DOI": "10.1002/j.1460-2075.1991.tb04966.x",
      "article-title": "Efficient gene transfer in C. elegans: extrachromosomal maintenance and integration of transforming sequences",
      "volume": "10",
      "author": "Mello",
      "year": "1991",
      "journal-title": "EMBO J"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C44",
      "doi-asserted-by": "crossref",
      "first-page": "933",
      "DOI": "10.1101/gad.7.6.933",
      "article-title": "lin-31, a Caenorhabditis elegans HNF-3/fork head transcription factor homolog, specifies three alternative cell fates in vulval development",
      "volume": "7",
      "author": "Miller",
      "year": "1993",
      "journal-title": "Genes Dev"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C45",
      "doi-asserted-by": "crossref",
      "first-page": "2354",
      "DOI": "10.1523/JNEUROSCI.15-03-02354.1995",
      "article-title": "Molecular characterization and spatial distribution of SAP97, a novel presynaptic protein homologous to SAP90 and the Drosophila discs-large tumor suppressor protein",
      "volume": "15",
      "author": "M\u00fcller",
      "year": "1995",
      "journal-title": "J. Neurosci"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C46",
      "first-page": "4886",
      "article-title": "Epidermal growth factor-induced mitogenesis in kidney epithelial cells (LLC-PK1)",
      "volume": "48",
      "author": "Mullin",
      "year": "1987",
      "journal-title": "Cancer Res"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C47",
      "doi-asserted-by": "crossref",
      "first-page": "283",
      "DOI": "10.1016/0079-6107(94)90003-5",
      "article-title": "Structure and function of the SH3 domain",
      "volume": "61",
      "author": "Musacchio",
      "year": "1994",
      "journal-title": "Prog. Biophys. Molec. Biol"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C48",
      "doi-asserted-by": "crossref",
      "first-page": "102",
      "DOI": "10.1016/S0968-0004(00)88973-2",
      "article-title": "DHR domains in syntrophins, neuronal NO synthases and other intracellular proteins",
      "volume": "20",
      "author": "Ponting",
      "year": "1995",
      "journal-title": "Trends Biochem. Sci"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C49",
      "doi-asserted-by": "crossref",
      "first-page": "1157",
      "DOI": "10.1126/science.8438166",
      "article-title": "Identification of a ten-amino acid proline-rich SH3 binding site",
      "volume": "259",
      "author": "Ren",
      "year": "1993",
      "journal-title": "Science"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C50",
      "doi-asserted-by": "crossref",
      "first-page": "6595",
      "DOI": "10.1073/pnas.88.15.6595",
      "article-title": "Molecular identification of a major palmitoylated erythrocyte membrane protein containing the src homology 3 motif",
      "volume": "88",
      "author": "Ruff",
      "year": "1991",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C51",
      "doi-asserted-by": "crossref",
      "first-page": "411",
      "DOI": "10.1126/science.7536343",
      "article-title": "FAP-1: a protein tyrosine phosphatase that associates with Fas",
      "volume": "268",
      "author": "Sato",
      "year": "1995",
      "journal-title": "Science"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C52",
      "volume-title": "Molecular Cloning",
      "author": "Sambrook",
      "year": "1989",
      "edition": "2nd"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C53",
      "doi-asserted-by": "crossref",
      "first-page": "65",
      "DOI": "10.1007/BF00966924",
      "article-title": "Multifunctional Ca2+/calmodulin-dependent protein kinase",
      "volume": "18",
      "author": "Schulman",
      "year": "1993",
      "journal-title": "Neurochem. Res"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C54",
      "doi-asserted-by": "crossref",
      "first-page": "142",
      "DOI": "10.1038/375142a0",
      "article-title": "Sequential signalling during Caenorhabditis elegans vulval induction",
      "volume": "375",
      "author": "Simske",
      "year": "1995",
      "journal-title": "Nature"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C55",
      "doi-asserted-by": "crossref",
      "first-page": "337",
      "DOI": "10.1016/0378-1119(86)90117-4",
      "article-title": "Kanamycin-resistant vectors that are analogues of plasmids pUC8, pUC9, pEMBL8 and pEMBL9",
      "volume": "41",
      "author": "Spratt",
      "year": "1986",
      "journal-title": "Gene"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C56",
      "doi-asserted-by": "crossref",
      "first-page": "1127",
      "DOI": "10.1016/0022-2836(92)90474-X",
      "article-title": "Refined structure of the complex between guanylate kinase and its substrate GMP at 2.0 \u00c5 resolution",
      "volume": "224",
      "author": "Stehle",
      "year": "1992",
      "journal-title": "J. Mol. Biol"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C57",
      "doi-asserted-by": "crossref",
      "first-page": "551",
      "DOI": "10.1038/335551a0",
      "article-title": "Lateral inhibition during vulval induction in Caenorhabditis elegans",
      "volume": "335",
      "author": "Sternberg",
      "year": "1988",
      "journal-title": "Nature"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C58",
      "doi-asserted-by": "crossref",
      "first-page": "761",
      "DOI": "10.1016/0092-8674(86)90842-1",
      "article-title": "Pattern formation during vulval development in C. elegans",
      "volume": "44",
      "author": "Sternberg",
      "year": "1986",
      "journal-title": "Cell"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C59",
      "doi-asserted-by": "crossref",
      "first-page": "679",
      "DOI": "10.1016/0092-8674(89)90103-7",
      "article-title": "The combined action of two intercellular signaling pathways specifies three cell fates during vulval induction in C. elegans",
      "volume": "58",
      "author": "Sternberg",
      "year": "1989",
      "journal-title": "Cell"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C60",
      "doi-asserted-by": "crossref",
      "first-page": "755",
      "DOI": "10.1083/jcb.103.3.755",
      "article-title": "Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia",
      "volume": "103",
      "author": "Stevenson",
      "year": "1986",
      "journal-title": "J. Cell Biol"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C61",
      "doi-asserted-by": "crossref",
      "first-page": "71",
      "DOI": "10.1016/0012-1606(72)90113-3",
      "article-title": "The recovery and preliminary characterization of X chromosome mutants affecting imaginal discs of Drosophila melanogaster",
      "volume": "27",
      "author": "Stewart",
      "year": "1972",
      "journal-title": "Dev. Biol"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C62",
      "doi-asserted-by": "crossref",
      "first-page": "95",
      "DOI": "10.1093/genetics/77.1.95",
      "article-title": "The DNA of Caenorhabditis elegans",
      "volume": "77",
      "author": "Sulston",
      "year": "1974",
      "journal-title": "Genetics"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C63",
      "doi-asserted-by": "crossref",
      "first-page": "110",
      "DOI": "10.1016/0012-1606(77)90158-0",
      "article-title": "Post-embryonic cell lineages of the nematode Caenorhabditis elegans",
      "volume": "56",
      "author": "Sulston",
      "year": "1977",
      "journal-title": "Dev. Biol"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C64",
      "doi-asserted-by": "crossref",
      "first-page": "64",
      "DOI": "10.1016/0012-1606(83)90201-4",
      "article-title": "The embryonic cell lineage of the nematode Caenorhabditis elegans",
      "volume": "100",
      "author": "Sulston",
      "year": "1983",
      "journal-title": "Dev. Biol"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C65",
      "doi-asserted-by": "crossref",
      "first-page": "429",
      "DOI": "10.1146/annurev.cb.08.110192.002241",
      "article-title": "Structural framework for the protein kinase family",
      "volume": "8",
      "author": "Taylor",
      "year": "1992",
      "journal-title": "Annu. Rev. Cell Biol"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C66",
      "doi-asserted-by": "crossref",
      "first-page": "1041",
      "DOI": "10.1016/0092-8674(90)90382-O",
      "article-title": "Cell interactions coordinate the development of the C. elegans egg-laying system",
      "volume": "62",
      "author": "Thomas",
      "year": "1990",
      "journal-title": "Cell"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C67",
      "doi-asserted-by": "crossref",
      "first-page": "143",
      "DOI": "10.1016/0092-8674(87)90019-5",
      "article-title": "Localization of the sevenless protein, a putative receptor for positional information, in the eye imaginal disc of Drosophila",
      "volume": "51",
      "author": "Tomlinson",
      "year": "1987",
      "journal-title": "Cell"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C68",
      "first-page": "1735",
      "article-title": "Epidermal growth factor induces tyrosine phosphorylation and reorganization of the tight junction protein ZO-1 in A431 cells",
      "volume-title": "J. Cell Sci",
      "author": "van Itallie",
      "year": "1995"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C69",
      "first-page": "81",
      "article-title": "The anatomy",
      "volume-title": "In The Nematode Caenorhabditis elegans",
      "author": "White",
      "year": "1988"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C70",
      "doi-asserted-by": "crossref",
      "first-page": "7834",
      "DOI": "10.1073/pnas.90.16.7834",
      "article-title": "The tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppressor protein of septate junctions",
      "volume": "90",
      "author": "Willott",
      "year": "1993",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C71",
      "doi-asserted-by": "crossref",
      "first-page": "32",
      "DOI": "10.1038/368032a0",
      "article-title": "2.2 mb of contiguous nucleotide sequence from chromosome III of C. elegans",
      "volume": "368",
      "author": "Wilson",
      "year": "1994",
      "journal-title": "Nature"
    },
    {
      "volume-title": "The Nematode Caenorhabditis elegans",
      "year": "1988",
      "author": "Wood",
      "key": "2025021322400564900_DEVELOP_122_1_97C72"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C73",
      "doi-asserted-by": "crossref",
      "first-page": "222",
      "DOI": "10.1016/0012-1606(89)90092-4",
      "article-title": "Molecular cloning of the lethal(1)discs large-1 oncogene of Drosophila",
      "volume": "134",
      "author": "Woods",
      "year": "1989",
      "journal-title": "Dev. Biol"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C74",
      "doi-asserted-by": "crossref",
      "first-page": "451",
      "DOI": "10.1016/0092-8674(81)90009-X",
      "article-title": "The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions",
      "volume": "66",
      "author": "Woods",
      "year": "1991",
      "journal-title": "Cell"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C75",
      "doi-asserted-by": "crossref",
      "first-page": "85",
      "DOI": "10.1016/0925-4773(93)90059-7",
      "article-title": "ZO-1, DlgA and PSD-95/SAP90: homologous proteins in tight, septate and synaptic cell junctions",
      "volume": "44",
      "author": "Woods",
      "year": "1993",
      "journal-title": "Mech. Dev"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C76",
      "doi-asserted-by": "crossref",
      "first-page": "742",
      "DOI": "10.1101/gad.9.6.742",
      "article-title": "MEK-2, a Caenorhabditis elegans MAP kinase kinase, functions in Ras-mediated vulval induction and other developmental events",
      "volume": "9",
      "author": "Wu",
      "year": "1995",
      "journal-title": "Genes Dev"
    },
    {
      "key": "2025021322400564900_DEVELOP_122_1_97C77",
      "doi-asserted-by": "crossref",
      "first-page": "448",
      "DOI": "10.1016/0012-1606(92)90299-V",
      "article-title": "Localization of DER and the pattern of cell divisions in wild-type and Ellipse eye imaginal discs",
      "volume": "149",
      "author": "Zak",
      "year": "1992",
      "journal-title": "Dev. Biol"
    }
  ],
  "container-title": "Development",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://journals.biologists.com/dev/article-pdf/122/1/97/3068219/develop_122_1_97.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "syndication"
    },
    {
      "URL": "https://journals.biologists.com/dev/article-pdf/122/1/97/3068219/develop_122_1_97.pdf",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2025,
        2,
        13
      ]
    ],
    "date-time": "2025-02-13T22:40:34Z",
    "timestamp": 1739486434000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://journals.biologists.com/dev/article/122/1/97/38912/The-C-elegans-vulval-induction-gene-lin-2-encodes"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1996,
        1,
        1
      ]
    ]
  },
  "references-count": 77,
  "journal-issue": {
    "issue": "1",
    "published-print": {
      "date-parts": [
        [
          1996,
          1,
          1
        ]
      ]
    }
  },
  "URL": "http://dx.doi.org/10.1242/dev.122.1.97",
  "relation": {},
  "ISSN": [
    "0950-1991",
    "1477-9129"
  ],
  "subject": [],
  "published": {
    "date-parts": [
      [
        1996,
        1,
        1
      ]
    ]
  }
}