DOI: 10.1242/dev.122.1.271. Developmental regulation of zebrafish MyoD in wild-type, no tail and spadetail embryos [Penn]

Developmental regulation of zebrafish MyoD in wild-type, no tail and spadetail embryos

10.1242/dev.122.1.271

Crossref journal-article

The Company of Biologists

Development (237)

Abstract

ABSTRACT We describe the isolation of the zebrafish MyoD gene and its expression in wild-type embryos and in two mutants with altered somite development, no tail (ntl) and spadetail (spt). In the wild-type embryo, MyoD expression first occurs in an early phase, extending from mid-gastrula to just prior to somite formation, in which cells directly adjacent to the axial mesoderm express the gene. In subsequent phases, during the anterior-to-posterior wave of somite formation and maturation, expression occurs within particular regions of each somite. In spt embryos, which lack normal paraxial mesoderm due to incorrect cell migration, early MyoD expression is not observed and transcripts are instead first detected in small groups of trunk cells that will develop into aberrant myotomal-like structures. In ntl embryos, which lack notochords and tails, the early phase of MyoD expression is also absent. However, the later phase of expression within the developing somites appears to occur at the normal time in the ntl mutants, indicating that the presomitogenesis and somitogenesis phases of MyoD expression can be uncoupled. In addition, we demonstrate that the entire paraxial mesoderm of wild-type embryos has the potential to express MyoD when Sonic hedgehog is expressed ubiquitously in the embryo, and that this potential is lost in some of the cells of the paraxial mesoderm lineage in no tail and spadetail embryos. We also show that MyoD expression precedes myogenin expression and follows or is coincident with expression of snail1 in some regions that express this gene.

Bibliography

Weinberg, E. S., Allende, M. L., Kelly, C. S., Abdelhamid, A., Murakami, T., Andermann, P., Doerre, O. G., Grunwald, D. J., & Riggleman, B. (1996). Developmental regulation of zebrafish MyoD in wild-type, no tail and spadetail embryos. Development, 122(1), 271â280.

Authors 9

Eric S. Weinberg (first)
Miguel L. Allende (additional)
Christina S. Kelly (additional)
Aboulmagd Abdelhamid (additional)
Tohru Murakami (additional)
Peter Andermann (additional)
O. Geoffrey Doerre (additional)
David J. Grunwald (additional)
Bob Riggleman (additional)

References 36 Referenced 584

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10.1016/0092-8674(94)90009-4 / Cell / Patterning of mammalian somites by surface ectoderm and notochord: evidence for sclerotome induction by a hedgehog homolog by Fan (1994)
10.1016/0012-1606(91)90314-S / Dev. Biol / The fub-1 mutation blocks initial myofibril formation in zebrafish muscle pioneer cells by Felsenfeld (1991)
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10.1016/S0092-8674(05)80087-X / Cell / Induction of muscle pioneers and floor plate is distinguished by the zebrafish no tail mutation by Halpern (1993)
10.1242/dev.121.12.4257 / Development / Cell-autonomous shift from axial to paraxial mesodermal development in zebrafish floating head mutants by Halpern (1995)
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10.1002/cne.902840303 / J. Comp. Neurol / Early expression of acetylcholinesterase activity in functionally distinct neurons of the zebrafish by Hanneman (1989)
10.1242/dev.108.4.669 / Development / The Xenopus MyoD gene: and unlocalized maternal mRNA predates lineage-restricted expression in the early embryo by Harvey (1990)
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{'volume-title': 'The Zebrafish Book: A Guide for the Laboratory Use of Zebrafish (Brachydanio rerio', 'year': '1993', 'author': 'Westerfield', 'key': '2025021322381911200_DEVELOP_122_1_271C36'} / The Zebrafish Book: A Guide for the Laboratory Use of Zebrafish (Brachydanio rerio by Westerfield (1993)

Dates

Type	When
Created	4 years, 4 months ago (April 25, 2021, 10:29 p.m.)
Deposited	6 months, 2 weeks ago (Feb. 13, 2025, 5:38 p.m.)
Indexed	3 weeks, 3 days ago (Aug. 7, 2025, 4:48 p.m.)
Issued	29 years, 8 months ago (Jan. 1, 1996)
Published	29 years, 8 months ago (Jan. 1, 1996)
Published Online	29 years, 8 months ago (Jan. 1, 1996)
Published Print	29 years, 8 months ago (Jan. 1, 1996)

Funders 0

None

BibTeX

@article{Weinberg_1996, title={Developmental regulation of zebrafish MyoD in wild-type, no tail and spadetail embryos}, volume={122}, ISSN={1477-9129}, url={http://dx.doi.org/10.1242/dev.122.1.271}, DOI={10.1242/dev.122.1.271}, number={1}, journal={Development}, publisher={The Company of Biologists}, author={Weinberg, Eric S. and Allende, Miguel L. and Kelly, Christina S. and Abdelhamid, Aboulmagd and Murakami, Tohru and Andermann, Peter and Doerre, O. Geoffrey and Grunwald, David J. and Riggleman, Bob}, year={1996}, month=jan, pages={271–280} }

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