DOI: 10.1242/dev.121.9.2847. Function of the Polycomb protein is conserved in mice and flies

Function of the Polycomb protein is conserved in mice and flies

10.1242/dev.121.9.2847

Crossref journal-article

The Company of Biologists

Development (237)

Abstract

ABSTRACT A key aspect of determination — the acquisition and propagation of cell fates — is the initiation of patterns of selector gene expression and their maintenance in groups of cells as they divide and develop. In Drosophila, in those groups of cells where particular selector genes must remain inactive, it is the Polycomb-Group of genes that keep them silenced. Here we show that M33, a mouse homologue of the Drosophila Polycomb protein, can substitute for Polycomb in transgenic flies. Polycomb protein is thought to join with other Polycomb-Group proteins to build a complex that silences selector genes. Since members of this group of proteins have their homologues in mice, our results suggest that the molecular mechanism of cell determination is widely conserved.

Bibliography

MÃ¼ller, J., Gaunt, S., & Lawrence, P. A. (1995). Function of the Polycomb protein is conserved in mice and flies. Development, 121(9), 2847â2852.

Authors 3

Jürg Müller (first)
Stephen Gaunt (additional)
Peter A. Lawrence (additional)

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Dates

Type	When
Created	4 years, 4 months ago (April 25, 2021, 10:24 p.m.)
Deposited	7 months, 1 week ago (Jan. 15, 2025, 10:01 a.m.)
Indexed	2 months ago (June 26, 2025, 2:26 p.m.)
Issued	29 years, 11 months ago (Sept. 1, 1995)
Published	29 years, 11 months ago (Sept. 1, 1995)
Published Online	29 years, 11 months ago (Sept. 1, 1995)
Published Print	29 years, 11 months ago (Sept. 1, 1995)

Funders 0

None

BibTeX

@article{M_ller_1995, title={Function of the Polycomb protein is conserved in mice and flies}, volume={121}, ISSN={1477-9129}, url={http://dx.doi.org/10.1242/dev.121.9.2847}, DOI={10.1242/dev.121.9.2847}, number={9}, journal={Development}, publisher={The Company of Biologists}, author={Müller, Jürg and Gaunt, Stephen and Lawrence, Peter A.}, year={1995}, month=sep, pages={2847–2852} }

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