DOI: 10.1242/dev.121.7.2099. Dorsalization of the neural tube by the non-neural ectoderm

Dorsalization of the neural tube by the non-neural ectoderm

10.1242/dev.121.7.2099

Crossref journal-article

The Company of Biologists

Development (237)

Abstract

ABSTRACT The patterning of cell types along the dorsoventral axis of the spinal cord requires a complex set of inductive signals. While the chordamesoderm is a well-known source of ventralizing signals, relatively little is known about the cues that induce dorsal cell types, including neural crest. Here, we demonstrate that juxtaposition of the non-neural and neural ectoderm is sufficient to induce the expression of dorsal markers, Wnt-1, Wnt-3a and Slug, as well as the formation of neural crest cells. In addition, the competence of neural plate to express Wnt-1 and Wnt-3a appears to be stage dependent, occurring only when neural tissue is taken from stage 8-10 embryos but not from stage 4 embryos, regardless of the age of the non-neural ectoderm. In contrast to the induction of Wnt gene expression, neural crest cell formation and Slug expression can be induced when either stage 4 or stage 8-10 neural plates are placed in contact with the non-neural ectoderm. These data suggest that the non-neural ectoderm provides a signal (or signals) that specifies dorsal cell types within the neural tube, and that the response is dependent on the competence of the neural tissue.

Bibliography

Dickinson, M. E., Selleck, M. A. J., McMahon, A. P., & Bronner-Fraser, M. (1995). Dorsalization of the neural tube by the non-neural ectoderm. Development, 121(7), 2099â2106.

Authors 4

Mary E. Dickinson (first)
Mark A. J. Selleck (additional)
Andrew P. McMahon (additional)
Marianne Bronner-Fraser (additional)

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Dates

Type	When
Created	4 years, 4 months ago (April 25, 2021, 10:23 p.m.)
Deposited	7 months, 1 week ago (Jan. 15, 2025, 9:13 a.m.)
Indexed	2 weeks, 5 days ago (Aug. 7, 2025, 4:27 p.m.)
Issued	30 years, 1 month ago (July 1, 1995)
Published	30 years, 1 month ago (July 1, 1995)
Published Online	30 years, 1 month ago (July 1, 1995)
Published Print	30 years, 1 month ago (July 1, 1995)

Funders 0

None

BibTeX

@article{Dickinson_1995, title={Dorsalization of the neural tube by the non-neural ectoderm}, volume={121}, ISSN={1477-9129}, url={http://dx.doi.org/10.1242/dev.121.7.2099}, DOI={10.1242/dev.121.7.2099}, number={7}, journal={Development}, publisher={The Company of Biologists}, author={Dickinson, Mary E. and Selleck, Mark A. J. and McMahon, Andrew P. and Bronner-Fraser, Marianne}, year={1995}, month=jul, pages={2099–2106} }

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