DOI: 10.1242/dev.121.3.855. Serrate expression can functionally replace Delta activity during neuroblast segregation in the Drosophila embryo

Serrate expression can functionally replace Delta activity during neuroblast segregation in the Drosophila embryo

10.1242/dev.121.3.855

Crossref journal-article

The Company of Biologists

Development (237)

Abstract

ABSTRACT Serrate and Delta encode structurally related proteins in D. melanogaster that bind within a common extracellular region on the NOTCH receptor molecule. We used ectopic expression to determine if SERRATE could mediate in vivo functions parallel or antagonistic to those proposed for the putative NOTCH ligand DELTA. Our results demonstrate that Serrate can replace Delta gene function during embryonic neuroblast segregation and that expression of Serrate leads to a NOTCH-dependent suppression of achaete expression in proneural clusters. Our findings strongly suggest that SERRATE functions as an alternative ligand capable of NOTCH activation.

Bibliography

Gu, Y., Hukriede, N. A., & Fleming, R. J. (1995). Serrate expression can functionally replace Delta activity during neuroblast segregation in the Drosophila embryo. Development, 121(3), 855â865.

Authors 3

Yi Gu (first)
Neil A. Hukriede (additional)
Robert J. Fleming (additional)

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Dates

Type	When
Created	4 years, 4 months ago (April 25, 2021, 10:10 p.m.)
Deposited	7 months, 2 weeks ago (Jan. 15, 2025, 8:48 a.m.)
Indexed	7 months, 2 weeks ago (Jan. 16, 2025, 12:29 a.m.)
Issued	30 years, 5 months ago (March 1, 1995)
Published	30 years, 5 months ago (March 1, 1995)
Published Online	30 years, 5 months ago (March 1, 1995)
Published Print	30 years, 5 months ago (March 1, 1995)

Funders 0

None

BibTeX

@article{Gu_1995, title={Serrate expression can functionally replace Delta activity during neuroblast segregation in the Drosophila embryo}, volume={121}, ISSN={1477-9129}, url={http://dx.doi.org/10.1242/dev.121.3.855}, DOI={10.1242/dev.121.3.855}, number={3}, journal={Development}, publisher={The Company of Biologists}, author={Gu, Yi and Hukriede, Neil A. and Fleming, Robert J.}, year={1995}, month=mar, pages={855–865} }

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  "abstract": "<jats:title>ABSTRACT</jats:title>\n               <jats:p>Serrate and Delta encode structurally related proteins in D. melanogaster that bind within a common extracellular region on the NOTCH receptor molecule. We used ectopic expression to determine if SERRATE could mediate in vivo functions parallel or antagonistic to those proposed for the putative NOTCH ligand DELTA. Our results demonstrate that Serrate can replace Delta gene function during embryonic neuroblast segregation and that expression of Serrate leads to a NOTCH-dependent suppression of achaete expression in proneural clusters. Our findings strongly suggest that SERRATE functions as an alternative ligand capable of NOTCH activation.</jats:p>",
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