DOI: 10.1242/dev.121.12.4303. Segmental patterning of heart precursors in <i>Drosophila</i>

Segmental patterning of heart precursors in Drosophila

10.1242/dev.121.12.4303

Crossref journal-article

The Company of Biologists

Development (237)

Abstract

ABSTRACT SUMMARY The mesoderm of Drosophila embryos is segmented; for instance there are segmentally arranged clusters of cells (some of which are heart precursors) that express even-skipped. Expression of even-skipped depends on Wingless, a secreted molecule. In principle, Wingless could act directly in the mesoderm or it could induce the pattern after crossing from ectoderm to mesoderm. Using mosaic embryos, we show that Wingless produced in the mesoderm is sufficient for even-skipped expression. This proves that induction is not essential. However, induction can occur: when patches of wingless mutant mesoderm are overlaid by wild-type ectoderm, they do express even-skipped. We therefore believe that Wingless from both the ectoderm and mesoderm may contribute to patterning the mesoderm. Using the UAS/Gal4 system, we made embryos in which the Wingless protein is uniformly expressed. This is sufficient to rescue the repeated clusters of even-skipped expressing cells, although they are enlarged. We conclude that the mesoderm is segmented in some way not dependent on the distribution of Wingless, suggesting a more permissive and less instructive role for the protein in this instance.

Bibliography

Lawrence, P. A., Bodmer, R., & Vincent, J.-P. (1995). Segmental patterning of heart precursors in Drosophila. Development, 121(12), 4303â4308.

Authors 3

Peter A. Lawrence (first)
Rolf Bodmer (additional)
Jean-Paul Vincent (additional)

References 34 Referenced 129

10.1101/gad.7.7b.1325 / Genes Dev / tinman and bagpipe: two homeo box genes that determine cell fates in the dorsal mesoderm of Drosophila by Azpiazu (1993)
10.1038/368208a0 / Nature / Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein by Basler (1994)
{'key': '2025011515235224400_DEVELOP_121_12_4303C3', 'first-page': '1013', 'article-title': 'The mesoderm and its derivatives', 'volume-title': 'The Development of Drosophila melanogaster (ed', 'author': 'Bate', 'year': '1993'} / The Development of Drosophila melanogaster (ed / The mesoderm and its derivatives by Bate (1993)
{'key': '2025011515235224400_DEVELOP_121_12_4303C4', 'first-page': '1055', 'article-title': 'Myogenesis and muscle patterning in Drosophila', 'volume': '316', 'author': 'Bate', 'year': '1993', 'journal-title': 'C. r. hebd. Acad. Sci Paris'} / C. r. hebd. Acad. Sci Paris / Myogenesis and muscle patterning in Drosophila by Bate (1993)
{'volume-title': 'wingless is required for the formation of a subset of muscle founder cells during Drosophila embryogenesis. Development 121', 'author': 'Baylies', 'key': '2025011515235224400_DEVELOP_121_12_4303C5'} / wingless is required for the formation of a subset of muscle founder cells during Drosophila embryogenesis. Development 121 by Baylies
10.1242/dev.118.3.719 / Development / The gene tinman is required for specification of the heart and visceral muscles in Drosophila by Bodmer (1993)
10.1016/1050-1738(94)00032-Q / Trends in Cardiovascular Med / Heart development in Drosophila and its relationship to vertebrates by Bodmer (1995)
10.1101/gad.9.6.730 / Genes Dev / Drosophila MEF2, a transcription factor that is essential for myogenesis by Bour (1995)
10.1242/dev.118.2.401 / Development / Targeted gene expression as means of altering cell fates and generating dominant phenotypes by Brand (1993)
10.1002/j.1460-2075.1994.tb06236.x / EMBO J / The Drosophila segment polarity gene patched interacts with decapentaplegic in wing development by Capdevila (1994)
10.1101/gad.4.12a.2098 / Genes Dev / A new Drosophila homeo box gene is expressed in mesodermal precursor cells of distinct muscles during embryogenesis by Dohrmann (1990)
10.1038/374464a0 / Nature / Induction of visceral and cardiac mesoderm by ectodermal Dpp in the early Drosophila embryo by Frasch (1995)
10.1002/j.1460-2075.1987.tb04817.x / EMBO J / Characterization and localization of the even-skipped protein of Drosophila by Frasch (1987)
10.1002/9780470720110.ch8 / Cell Patterning (CIBA Foundation Symp) / Genetic control of wing disc development in Drosophila by Garcia-Bellido (1975)
10.1038/362630a0 / Nature / Homeotic genes autonomously specify one aspect of pattern in the Drosophila mesoderm by Greig (1993)
10.1073/pnas.89.5.1919 / Proc. Natl Acad. Sci. USA / Altering the insertional specificity of a Drosophila transposable element by Kassis (1992)
10.1016/0012-1606(81)90194-9 / Dev. Biol / Compartments in the abdomen of Drosophila and the role of the engrailed locus by Kornberg (1981)
{'volume-title': 'The Making of a Fly', 'year': '1992', 'author': 'Lawrence', 'key': '2025011515235224400_DEVELOP_121_12_4303C18'} / The Making of a Fly by Lawrence (1992)
10.1002/j.1460-2075.1984.tb02217.x / EMBO J / On the role of the engrailed+ gene in the internal organs of Drosophila by Lawrence (1984)
10.1242/dev.105.4.761 / Development / Pattern formation in the Drosophila embryo: allocation of cells to parasegments by even-skipped and fushi tarazu by Lawrence (1989)
10.1242/dev.120.12.3355 / Development / Wingless can bring about a mesoderm-to-ectoderm induction in Drosophila embryos by Lawrence (1994)
10.1038/313639a0 / Nature / Parasegments and compartments in the Drosophila embryo by Martinez-Arias (1985)
10.1242/dev.120.4.755 / Development / Muscle pattern diversification in Drosophila is determined by the autonomous function of homeotic genes in the embryonic mesoderm by Michelson (1994)
10.1038/255614a0 / Nature / Control of compartment development by the engrailed gene in Drosophila by Morata (1975)
10.1242/dev.116.3.711 / Development / The consequences of ubiquitous expression of the wingless gene in the Drosophila embryo by Noordermeer (1992)
10.1016/0092-8674(92)90630-U / Cell / Wnt genes by Nusse (1992)
10.1038/287795a0 / Nature / Mutations affecting segment number and polarity in Drosophila by Nüsslein-Volhard (1980)
10.1016/0092-8674(94)90351-4 / Cell / The genetic basis of patterned baldness in Drosophila by Perrimon (1994)
10.1242/dev.117.2.677 / Development / A role for wingless in the segmental gradient of Drosophila? by Sampedro (1993)
10.1038/372783a0 / Nature / dpp induces mesodermal gene expression in Drosophila by Staehling-Hampton (1994)
10.1002/j.1460-2075.1989.tb08409.x / EMBO J / An essential role of even-skipped for homeotic gene expression in the Drosophila visceral mesoderm by Tremml (1989)
10.1016/0092-8674(89)90020-2 / Cell / Distribution of the wingless gene product in Drosophila embryos: a protein involved in cell-cell comunication by Van den Heuvel (1989)
10.1016/0092-8674(94)90139-2 / Cell / Drosophila wingless sustains engrailed expression only in adjoining cells: evidence from mosaic embryos by Vincent (1994)
10.1006/dbio.1995.1174 / Dev. Biol / Heart development in Drosophila requires the segment polarity gene wingless by Wu (1995)

Dates

Type	When
Created	4 years, 4 months ago (April 25, 2021, 10:17 p.m.)
Deposited	7 months, 2 weeks ago (Jan. 15, 2025, 10:24 a.m.)
Indexed	1 month, 1 week ago (July 19, 2025, 11:25 p.m.)
Issued	29 years, 9 months ago (Dec. 1, 1995)
Published	29 years, 9 months ago (Dec. 1, 1995)
Published Online	29 years, 9 months ago (Dec. 1, 1995)
Published Print	29 years, 9 months ago (Dec. 1, 1995)

Funders 0

None

BibTeX

@article{Lawrence_1995, title={Segmental patterning of heart precursors in Drosophila}, volume={121}, ISSN={1477-9129}, url={http://dx.doi.org/10.1242/dev.121.12.4303}, DOI={10.1242/dev.121.12.4303}, number={12}, journal={Development}, publisher={The Company of Biologists}, author={Lawrence, Peter A. and Bodmer, Rolf and Vincent, Jean-Paul}, year={1995}, month=dec, pages={4303–4308} }

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