DOI: 10.1242/dev.121.12.4257. Cell-autonomous shift from axial to paraxial mesodermal development in zebrafish <i>floating head</i> mutants [Penn]

Cell-autonomous shift from axial to paraxial mesodermal development in zebrafish floating head mutants

10.1242/dev.121.12.4257

Crossref journal-article

The Company of Biologists

Development (237)

Abstract

ABSTRACT Zebrafish floating head mutant embryos lack notochord and develop somitic muscle in its place. This may result from incorrect specification of the notochord domain at gastrulation, or from respecification of notochord progen-itors to form muscle. In genetic mosaics, floating head acts cell autonomously. Transplanted wild-type cells differenti-ate into notochord in mutant hosts; however, cells from floating head mutant donors produce muscle rather than notochord in wild-type hosts. Consistent with respecifica-tion, markers of axial mesoderm are initially expressed in floating head mutant gastrulas, but expression does not persist. Axial cells also inappropriately express markers of paraxial mesoderm. Thus, single cells in the mutant midline transiently co-express genes that are normally specific to either axial or paraxial mesoderm. Since floating head mutants produce some floor plate in the ventral neural tube, midline mesoderm may also retain early signaling capabilities. Our results suggest that wild-type floating head provides an essential step in maintaining, rather than initiating, development of notochord-forming axial mesoderm.

Bibliography

Halpern, M. E., Thisse, C., Ho, R. K., Thisse, B., Riggleman, B., Trevarrow, B., Weinberg, E. S., Postlethwait, J. H., & Kimmel, C. B. (1995). Cell-autonomous shift from axial to paraxial mesodermal development in zebrafish floating head mutants. Development, 121(12), 4257â4264.

Authors 9

M. E. Halpern (first)
C. Thisse (additional)
R. K. Ho (additional)
B. Thisse (additional)
B. Riggleman (additional)
B. Trevarrow (additional)
E. S. Weinberg (additional)
J. H. Postlethwait (additional)
C. B. Kimmel (additional)

References 28 Referenced 158

{'key': '2025011515265800500_DEVELOP_121_12_4257C1', 'first-page': '1327', 'article-title': 'Genetic dissection of eye development in Drosophila', 'volume-title': 'The Development of Drosophila melanogaster', 'author': 'Dickson', 'year': '1993'} / The Development of Drosophila melanogaster / Genetic dissection of eye development in Drosophila by Dickson (1993)
10.1016/0959-437X(94)90065-B / Curr. Opinion in Genetics and Devel / Signal transduction and cell fate specification during Caenorhabditis elegans vulval development by Eisenmann (1994)
10.1016/0012-1606(91)90314-S / Dev. Biol / The fub-1 mutation blocks initial myofibril formation in zebrafish muscle pioneers by Felsenfeld (1991)
10.1242/dev.119.4.991 / Development / Tail formation as a continuation of gastrulation: the multiple cell populations of the Xenopus tailbud derive from the late blastopore lip by Gont (1993)
10.1016/0092-8674(92)90550-V / Cell / Responses of embryonic Xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesoderm by Green (1992)
10.1038/371487a0 / Nature / Activin signalling and response to a morphogen gradient by Gurdon (1994)
10.1016/S0092-8674(05)80087-X / Cell / Induction of muscle pioneers and floor plate is distinguished by the zebrafish no tail mutation by Halpern (1993)
10.1242/dev.119.4.1107 / Development / The expression of a zebrafish gene homologous to Drosophila snail suggests a conserved function in invertebrate and vertebrate gastrulation by Hammerschmidt (1993)
10.1016/0896-6273(92)90027-B / Neuron / Role of the floor plate in axonal patterning in the zebrafish CNS by Hatta (1992)
10.1038/348728a0 / Nature / Cell-autonomous action of zebrafish spt-1 mutation in specific mesodermal precursors by Ho (1990)
10.1126/science.8316841 / Science / Commitment of cell fate in the early zebrafish embryo by Ho (1993)
10.3109/10520297409116929 / Stain Technology / A simple methylene blue-azure II-basic fuchsin stain for epoxy-embedded tissue sections by Humphrey (1974)
10.1002/aja.1002030302 / Dev Dynamics / Stages of embryonic development of the zebrafish by Kimmel (1995)
10.1139/z85-356 / Can. J. Zool / Kupffer’s vesicle in Brachydanio rerio: multivesicular origin and proposed function in vitro by Laale (1985)
10.1126/science.7754368 / Science / Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein by Lee (1995)
10.1016/0169-2607(91)90079-9 / Comput. Methods Programs Biomed / NeuroVideo: a program for capturing and processing time-lapse video by Myers (1991)
10.1242/dev.116.4.1021 / Development / The protein product of the zebrafish homologue of the mouse T gene is expressed in nuclei of the germ ring and the notochord of the early embryo by Schulte-Merker (1992)
10.1242/dev.120.4.1009 / Development / no tail (ntl) is the zebrafish homologue of the mouse T (Brachyury) gene by Schulte-Merker (1994)
10.1111/j.1432-0436.1985.tb00302.x / Differentiation / Biochemical specificity of Xenopus notochord by Smith (1985)
10.1093/genetics/112.2.311 / Genetics / Segregation analyses and gene-centromere distances in the zebrafish by Streisinger (1986)
{'key': '2025011515265800500_DEVELOP_121_12_4257C21', 'article-title': 'Requirement for the homeobox gene floating head in zebrafish development', 'volume-title': 'Nature (in press)', 'author': 'Talbot', 'year': '1995'} / Nature (in press) / Requirement for the homeobox gene floating head in zebrafish development by Talbot (1995)
10.1242/dev.119.4.1203 / Development / Structure of the zebrafish snail1 gene and its expression in wild-type, spadetail and no tail mutant embryos by Thisse (1993)
10.1016/0896-6273(90)90194-K / Neuron / Organization of hindbrain segments in the zebrafish embryo by Trevarrow (1990)
10.1101/gad.7.3.355 / Genes Dev / Induction of the Xenopus organizer: expression and regulation of Xnot, a novel FGF and activin-regulated homeo box gene by von Dassow (1993)
10.1126/science.1846704 / Science / The myoD gene family: nodal point during specification of the muscle cell lineage by Weintraub (1991)
{'volume-title': 'The Zebrafish Book', 'year': '1993', 'author': 'Westerfield', 'key': '2025011515265800500_DEVELOP_121_12_4257C26'} / The Zebrafish Book by Westerfield (1993)
10.1002/aja.1002030308 / Dev. Dynamics / Expression of a type II collagen gene in the zebrafish embryonic axis by Yan (1995)
10.1146/annurev.ne.17.030194.002105 / Ann. Rev. Neurosci / Determination of neuronal cell fate: lessons from the R7 neuron of Drosophila by Zipursky (1994)

Dates

Type	When
Created	4 years, 4 months ago (April 25, 2021, 10:15 p.m.)
Deposited	7 months, 2 weeks ago (Jan. 15, 2025, 10:27 a.m.)
Indexed	1 month, 1 week ago (July 24, 2025, 8:22 a.m.)
Issued	29 years, 9 months ago (Dec. 1, 1995)
Published	29 years, 9 months ago (Dec. 1, 1995)
Published Online	29 years, 9 months ago (Dec. 1, 1995)
Published Print	29 years, 9 months ago (Dec. 1, 1995)

Funders 0

None

BibTeX

@article{Halpern_1995, title={Cell-autonomous shift from axial to paraxial mesodermal development in zebrafish floating head mutants}, volume={121}, ISSN={1477-9129}, url={http://dx.doi.org/10.1242/dev.121.12.4257}, DOI={10.1242/dev.121.12.4257}, number={12}, journal={Development}, publisher={The Company of Biologists}, author={Halpern, M. E. and Thisse, C. and Ho, R. K. and Thisse, B. and Riggleman, B. and Trevarrow, B. and Weinberg, E. S. and Postlethwait, J. H. and Kimmel, C. B.}, year={1995}, month=dec, pages={4257–4264} }

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