DOI: 10.1242/dev.121.10.3291. Disruption of the mouse <i>RBP-J</i>к gene results in early embryonic death

Disruption of the mouse RBP-Jк gene results in early embryonic death

10.1242/dev.121.10.3291

Crossref journal-article

The Company of Biologists

Development (237)

Abstract

ABSTRACT The RBP-Jк protein is a transcription factor that recog-nizes the sequence C(T)GTGGGGA. The RBP-Jк gene is highly conserved in a wide variety of species and the Drosophila homologue has been shown to be identical to Suppressor of Hairless [Su(H)] which plays important roles in the development of the peripheral nervous system. To explore the function of the RBP-Jк gene in mouse embryo-genesis, a mutation was introduced into the functional RBP-Jк gene in embryonic stem (ES) cells by homologous recombination. Null mutant ES cells survived but null mutant mice showed embryonic lethality before 10.5 days of gestation. The mutant mice showed severe growth retar-dation as early as 8.5 days of gestation. Developmental abnormalities, including incomplete turning of the body axis, microencephaly, abnormal placental development, anterior neuropore opening and defective somitogenesis, were observed in the mutant mice at 9.5 days of gestation. RBP-Jк mutant embryos expressed a posterior mesoder-mal marker FGFR1. Their irregularly shaped somites expressed a somite marker gene Mox 1 but failed to express myogenin. The RBP-Jк gene was revealed to be essential for postimplantation development of mice.

Bibliography

Oka, C., Nakano, T., Wakeham, A., Pompa, J. L. de la, Mori, C., Sakai, T., Okazaki, S., Kawaichi, M., Shiota, K., Mak, T. W., & Honjo, T. (1995). Disruption of the mouse RBP-JÐº gene results in early embryonic death. Development, 121(10), 3291â3301.

Authors 11

Chio Oka (first)
Toru Nakano (additional)
Andrew Wakeham (additional)
Jose Luis de la Pompa (additional)
Chisato Mori (additional)
Takashi Sakai (additional)
Saeko Okazaki (additional)
Masashi Kawaichi (additional)
Kohei Shiota (additional)
Tak W. Mak (additional)
Tasuku Honjo (additional)

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Dates

Type	When
Created	4 years, 4 months ago (April 25, 2021, 10:11 p.m.)
Deposited	7 months, 1 week ago (Jan. 15, 2025, 10:08 a.m.)
Indexed	4 weeks, 2 days ago (July 26, 2025, 4:51 a.m.)
Issued	29 years, 10 months ago (Oct. 1, 1995)
Published	29 years, 10 months ago (Oct. 1, 1995)
Published Online	29 years, 10 months ago (Oct. 1, 1995)
Published Print	29 years, 10 months ago (Oct. 1, 1995)

Funders 0

None

BibTeX

@article{Oka_1995, title={Disruption of the mouse RBP-Jк gene results in early embryonic death}, volume={121}, ISSN={1477-9129}, url={http://dx.doi.org/10.1242/dev.121.10.3291}, DOI={10.1242/dev.121.10.3291}, number={10}, journal={Development}, publisher={The Company of Biologists}, author={Oka, Chio and Nakano, Toru and Wakeham, Andrew and Pompa, Jose Luis de la and Mori, Chisato and Sakai, Takashi and Okazaki, Saeko and Kawaichi, Masashi and Shiota, Kohei and Mak, Tak W. and Honjo, Tasuku}, year={1995}, month=oct, pages={3291–3301} }

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  "abstract": "<jats:title>ABSTRACT</jats:title>\n               <jats:p>The RBP-J\u043a protein is a transcription factor that recog-nizes the sequence C(T)GTGGGGA. The RBP-J\u043a gene is highly conserved in a wide variety of species and the Drosophila homologue has been shown to be identical to Suppressor of Hairless [Su(H)] which plays important roles in the development of the peripheral nervous system. To explore the function of the RBP-J\u043a gene in mouse embryo-genesis, a mutation was introduced into the functional RBP-J\u043a gene in embryonic stem (ES) cells by homologous recombination. Null mutant ES cells survived but null mutant mice showed embryonic lethality before 10.5 days of gestation. The mutant mice showed severe growth retar-dation as early as 8.5 days of gestation. Developmental abnormalities, including incomplete turning of the body axis, microencephaly, abnormal placental development, anterior neuropore opening and defective somitogenesis, were observed in the mutant mice at 9.5 days of gestation. RBP-J\u043a mutant embryos expressed a posterior mesoder-mal marker FGFR1. Their irregularly shaped somites expressed a somite marker gene Mox 1 but failed to express myogenin. The RBP-J\u043a gene was revealed to be essential for postimplantation development of mice.</jats:p>",
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