DOI: 10.1242/dev.120.6.1621. Role of transforming growth factor-beta isoforms in regulating the expression of nerve growth factor and neurotrophin-3 mRNA levels in embryonic cutaneous cells at different stages of development

Role of transforming growth factor-beta isoforms in regulating the expression of nerve growth factor and neurotrophin-3 mRNA levels in embryonic cutaneous cells at different stages of development

10.1242/dev.120.6.1621

Crossref journal-article

The Company of Biologists

Development (237)

Abstract

ABSTRACT We have investigated if transforming growth factor-beta (TGF-β) isoforms influence the level of expression of nerve growth factor (NGF) mRNA and neurotrophin-3 (NT-3) mRNA in embryonic tissues innervated by neurons that depend on NGF and NT-3 for survival. Presumptive dermal and epidermal cells from the maxillary territory of the embryonic mouse trigeminal ganglion were cultured in defined medium during the early stages of innervation when trigeminal neurons switch their survival dependence from NT-3 to NGF. In E11 and E12 cultures, when the in vivo levels of NGF mRNA and NT-3 mRNA are increasing, TGF-β1, TGF-β2 and TGF-β3 each increased the level of NGF mRNA but had no effect on NT-3 mRNA. In E13 cultures, when the in vivo levels of NGF mRNA and NT-3 mRNA reach a peak (relative to actin mRNA) prior to a marked fall in the level of NT-3 mRNA and a gradual decrease in the level of NGF mRNA, TGF-βs promoted further increases in the level of NGF mRNA but caused a decrease in the level of NT-3 mRNA. All three TGF-β mRNAs were detected in the maxillary territory in vivo before the arrival of the earliest axons and their levels rose throughout the period in which sensory axons reach this territory. Our findings demonstrate age-related changes in the influence of TGF-βs on the expression of neurotrophins in developing cutaneous cells and raise the possibility that TGF-βs play a role in regulating the changing patterns of neurotrophin gene expression in sensory neuron target fields.

Bibliography

Buchman, V. L., Sporn, M., & Davies, A. M. (1994). Role of transforming growth factor-beta isoforms in regulating the expression of nerve growth factor and neurotrophin-3 mRNA levels in embryonic cutaneous cells at different stages of development. Development, 120(6), 1621â1629.

Authors 3

Vladimir L. Buchman (first)
Michael Sporn (additional)
Alun M. Davies (additional)

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Dates

Type	When
Created	4 years, 4 months ago (April 23, 2021, 2:52 p.m.)
Deposited	8 months, 1 week ago (Dec. 17, 2024, 6:24 p.m.)
Indexed	8 months, 1 week ago (Dec. 18, 2024, 12:40 a.m.)
Issued	31 years, 2 months ago (June 1, 1994)
Published	31 years, 2 months ago (June 1, 1994)
Published Online	31 years, 2 months ago (June 1, 1994)
Published Print	31 years, 2 months ago (June 1, 1994)

Funders 0

None

BibTeX

@article{Buchman_1994, title={Role of transforming growth factor-beta isoforms in regulating the expression of nerve growth factor and neurotrophin-3 mRNA levels in embryonic cutaneous cells at different stages of development}, volume={120}, ISSN={1477-9129}, url={http://dx.doi.org/10.1242/dev.120.6.1621}, DOI={10.1242/dev.120.6.1621}, number={6}, journal={Development}, publisher={The Company of Biologists}, author={Buchman, Vladimir L. and Sporn, Michael and Davies, Alun M.}, year={1994}, month=jun, pages={1621–1629} }

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  "abstract": "<jats:title>ABSTRACT</jats:title>\n               <jats:p>We have investigated if transforming growth factor-beta (TGF-\u03b2) isoforms influence the level of expression of nerve growth factor (NGF) mRNA and neurotrophin-3 (NT-3) mRNA in embryonic tissues innervated by neurons that depend on NGF and NT-3 for survival. Presumptive dermal and epidermal cells from the maxillary territory of the embryonic mouse trigeminal ganglion were cultured in defined medium during the early stages of innervation when trigeminal neurons switch their survival dependence from NT-3 to NGF. In E11 and E12 cultures, when the in vivo levels of NGF mRNA and NT-3 mRNA are increasing, TGF-\u03b21, TGF-\u03b22 and TGF-\u03b23 each increased the level of NGF mRNA but had no effect on NT-3 mRNA. In E13 cultures, when the in vivo levels of NGF mRNA and NT-3 mRNA reach a peak (relative to actin mRNA) prior to a marked fall in the level of NT-3 mRNA and a gradual decrease in the level of NGF mRNA, TGF-\u03b2s promoted further increases in the level of NGF mRNA but caused a decrease in the level of NT-3 mRNA. All three TGF-\u03b2 mRNAs were detected in the maxillary territory in vivo before the arrival of the earliest axons and their levels rose throughout the period in which sensory axons reach this territory. Our findings demonstrate age-related changes in the influence of TGF-\u03b2s on the expression of neurotrophins in developing cutaneous cells and raise the possibility that TGF-\u03b2s play a role in regulating the changing patterns of neurotrophin gene expression in sensory neuron target fields.</jats:p>",
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