DOI: 10.1242/dev.120.6.1581. Early phenotypic choices by neuronal precursors, revealed by clonal analysis of the chick embryo hindbrain

Early phenotypic choices by neuronal precursors, revealed by clonal analysis of the chick embryo hindbrain

10.1242/dev.120.6.1581

Crossref journal-article

The Company of Biologists

Development (237)

Abstract

ABSTRACT The mechanisms that generate diverse neuronal phenotypes within the central nervous system are thought to involve local cues or cell-cell interactions acting late in neurogenesis, perhaps as late as the last precursor cell division. We describe here a clonal analysis of neuronal development in the chick hindbrain, using an intracellular tracer to mark single precursor cells, that suggests the operation of an alternative strategy. The majority of clones, ranging from 1 to 46 cells, contained neurons of only one of several possible phenotypes. These single-phenotype clones were not positionally restricted within a rhombomere but were interspersed with other clones containing distinct phenotypes. The assignment of neuronal phenotype in this brain region may, therefore, be made in early precursors and remembered through several rounds of mitotic expansion and dispersal.

Bibliography

Lumsden, A., Clarke, J. D. W., Keynes, R., & Fraser, S. (1994). Early phenotypic choices by neuronal precursors, revealed by clonal analysis of the chick embryo hindbrain. Development, 120(6), 1581â1589.

Authors 4

Andrew Lumsden (first)
Jonathan D. W. Clarke (additional)
Roger Keynes (additional)
Scott Fraser (additional)

References 41 Referenced 57

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Dates

Type	When
Created	4 years, 4 months ago (April 23, 2021, 2:49 p.m.)
Deposited	8 months, 1 week ago (Dec. 17, 2024, 6:21 p.m.)
Indexed	1 month, 3 weeks ago (July 7, 2025, 2:30 a.m.)
Issued	31 years, 2 months ago (June 1, 1994)
Published	31 years, 2 months ago (June 1, 1994)
Published Online	31 years, 2 months ago (June 1, 1994)
Published Print	31 years, 2 months ago (June 1, 1994)

Funders 0

None

BibTeX

@article{Lumsden_1994, title={Early phenotypic choices by neuronal precursors, revealed by clonal analysis of the chick embryo hindbrain}, volume={120}, ISSN={1477-9129}, url={http://dx.doi.org/10.1242/dev.120.6.1581}, DOI={10.1242/dev.120.6.1581}, number={6}, journal={Development}, publisher={The Company of Biologists}, author={Lumsden, Andrew and Clarke, Jonathan D. W. and Keynes, Roger and Fraser, Scott}, year={1994}, month=jun, pages={1581–1589} }

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