DOI: 10.1242/dev.120.6.1453. Evidence for a mitogenic effect of Wnt-1 in the developing mammalian central nervous system

Evidence for a mitogenic effect of Wnt-1 in the developing mammalian central nervous system

10.1242/dev.120.6.1453

Crossref journal-article

The Company of Biologists

Development (237)

Abstract

ABSTRACT The analysis of mutant alleles at the Wnt-1 locus has demonstrated that Wnt-1-mediated cell signalling plays a critical role in development of distinct regions of the embryonic central nervous system (CNS). To determine how these signals participate in the formation of the CNS, we have ectopically expressed this factor in the spinal cord under the control of the Hoxb-4 Region A enhancer. Ectopic Wnt-1 expression causes a dramatic increase in the number of cells undergoing mitosis in the ventricular region and a concomitant ventricular expansion. Although this leads to consistent changes in the relative proportions of dorsal and ventral regions, Wnt-1 does not appear to act as a primary patterning signal. Rather, our experiments indicate that Wnt-1 can act as a mitogen in the developing CNS.

Bibliography

Dickinson, M. E., Krumlauf, R., & McMahon, A. P. (1994). Evidence for a mitogenic effect of Wnt-1 in the developing mammalian central nervous system. Development, 120(6), 1453â1471.

Authors 3

Mary E. Dickinson (first)
Robb Krumlauf (additional)
Andrew P. McMahon (additional)

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Dates

Type	When
Created	4 years, 4 months ago (April 23, 2021, 2:43 p.m.)
Deposited	8 months, 1 week ago (Dec. 17, 2024, 6:24 p.m.)
Indexed	1 month, 4 weeks ago (July 2, 2025, 2:48 p.m.)
Issued	31 years, 2 months ago (June 1, 1994)
Published	31 years, 2 months ago (June 1, 1994)
Published Online	31 years, 2 months ago (June 1, 1994)
Published Print	31 years, 2 months ago (June 1, 1994)

Funders 0

None

BibTeX

@article{Dickinson_1994, title={Evidence for a mitogenic effect of Wnt-1 in the developing mammalian central nervous system}, volume={120}, ISSN={1477-9129}, url={http://dx.doi.org/10.1242/dev.120.6.1453}, DOI={10.1242/dev.120.6.1453}, number={6}, journal={Development}, publisher={The Company of Biologists}, author={Dickinson, Mary E. and Krumlauf, Robb and McMahon, Andrew P.}, year={1994}, month=jun, pages={1453–1471} }

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