DOI: 10.1242/dev.120.5.1233. Null alleles reveal novel requirements for <i>Bic-D</i> during <i>Drosophila</i> oogenesis and zygotic development

Null alleles reveal novel requirements for Bic-D during Drosophila oogenesis and zygotic development

10.1242/dev.120.5.1233

Crossref journal-article

The Company of Biologists

Development (237)

Abstract

ABSTRACT In the Drosophila ovary, the Bicaudal-D (Bic-D) gene is required for the differentiation of one of 16 interconnected cystocyte sister cells into an oocyte. A new class of Bic-Dnull alleles reveals a novel requirement for Bic-D for zygotic viability. In the germ line, the null mutations show that developmental processes that take place in germarial region 1, even those that create asymmetry, are independent of Bic-D function. Bic-D is then required to establish oocyte identity in one cystocyte and is essential, not only for the oocyte-specific accumulation of all oocyte markers that we have tested so far, but also for the posterior migration of the oocyte. In addition, normal polarity amongst the nurse cells requires Bic-D, indicating that the creation of different nurse cell identities may depend on oocyte determination. Our results show that different processes in early oogenesis require different amounts of Bic-D in a processspecific way and certain later processes can proceed at low levels of Bic-D. This suggests that the patterning of the female germ line and the development of an oocyte depend on differential responses to a single activity that is capable of initiating distinct oogenesis processes and can establish different cell fates.

Bibliography

Ran, B., Bopp, R., & Suter, B. (1994). Null alleles reveal novel requirements for Bic-D during Drosophila oogenesis and zygotic development. Development, 120(5), 1233â1242.

Authors 3

Bing Ran (first)
Rita Bopp (additional)
Beat Suter (additional)

References 31 Referenced 82

{'key': '2023120300564040300_DEVELOP_120_5_1233C1', 'first-page': '41', 'article-title': 'Studies on the events resulting in the formation of an egg chamber in Drosophila melanogaster', 'volume': '28', 'author': 'Brown', 'year': '1964', 'journal-title': 'Growth'} / Growth / Studies on the events resulting in the formation of an egg chamber in Drosophila melanogaster by Brown (1964)
10.1093/genetics/129.4.1061 / Genetics / Identification of grandchildless loci whose products are required for normal germ-line development in the nematode Caenorhabditis elegans by Capowski (1991)
10.1007/BF00319833 / Chromosoma / Electron microscopy of meiosis in Drosophila melanogaster females by Carpenter (1975)
10.1242/dev.114.3.653 / Development / Evidence for a highly selective RNA transport system and its role in establishing the dorsoventral axis of the Drosophila egg by Cheung (1992)
10.1242/dev.115.4.989 / Development / 3’ non-translated sequences in Drosophila cyclin B transcripts direct posterior pole accumulation late in oogenesis and peri-nuclear association in syncytial embryos by Dalby (1992)
10.1016/0092-8674(91)90137-N / Cell / oskar organizes the germ plasm and directs localization of the posterior determinant nanos by Ephrussi (1991)
10.1126/science.2035025 / Science / Site-specific recombination between homologous chromosomes in Drosophila by Golic (1991)
10.1101/gad.5.11.2060 / Genes Dev / tudor, a posterior-group gene of Drosophila melanogaster, encodes a novel protein and an mRNA localized during mid-oogenesis by Golumbeski (1991)
{'key': '2023120300564040300_DEVELOP_120_5_1233C9', 'article-title': 'Mutagenesis', 'volume-title': 'Drosophila, a Practical Approach', 'author': 'Grigliatti', 'year': '1986'} / Drosophila, a Practical Approach / Mutagenesis by Grigliatti (1986)
10.1016/0092-8674(91)90136-M / Cell / oskar mRNA is localized to the posterior pole of the Drosophila oocyte by Kim-Ha (1991)
{'key': '2023120300564040300_DEVELOP_120_5_1233C11', 'volume-title': 'Ovarian Development in Drosophila melanogaster', 'author': 'King', 'year': '1970'} / Ovarian Development in Drosophila melanogaster by King (1970)
10.1007/BF00336421 / Z. Zellforsch. Mikrosk. Anat / Further studies on the ring canal system of the ovarian cystocytes of Drosophila melanogaster by Koch (1969)
10.1002/jmor.1051210106 / J. Morph / The division and differentiation of Drosophila cystocytes by Koch (1967)
10.1007/BF00206261 / Cell Tissue Res / Multiple effects of colchicine in oogenesis in Drosophila: Induced sterility and switch of potential oocyte to nurse-cell developmental pathway by Koch (1983)
10.1242/dev.115.1.75 / Development / The Drosophila orb gene is predicted to encode sex-specific germline RNA-binding proteins and has localized transcripts in ovaries and early embryos by Lantz (1992)
10.1002/bies.950140802 / BioEssays / Molecular movements in oocyte patterning and pole cell differentiation by Lasko (1992)
{'key': '2023120300564040300_DEVELOP_120_5_1233C17', 'volume-title': 'The Genome of Drosophila melanogaster', 'author': 'Lindsley', 'year': '1992'} / The Genome of Drosophila melanogaster by Lindsley (1992)
{'key': '2023120300564040300_DEVELOP_120_5_1233C18', 'first-page': '141', 'article-title': 'Oogenesis', 'volume-title': 'The Genetics and Biology of Drosophila', 'author': 'Mahowald', 'year': '1980'} / The Genetics and Biology of Drosophila / Oogenesis by Mahowald (1980)
10.1007/BF00338705 / Z. Zellforsch. Mikroskop. Anat / Intrazelluläre Brücken (Fusome) in Hiden und im EiNährzellverband von Drosophila melanogaster by Meyer (1961)
10.1093/genetics/112.4.803 / Genetics / Dominant maternal-effect mutations of Drosophila melanogaster causing the production of double-abdomen embryos by Mohler (1986)
10.1093/genetics/129.4.1119 / Genetics / Female sterile mutations on the second chromosome of Drosophila melanogaster: II. Mutations blocking oogenesis or altering egg morphology by Schüpbach (1991)
10.1093/genetics/113.3.665 / Genetics / The genetics of the dorsalBicaudal-D region of Drosophila melanogaster by Steward (1986)
10.1101/gad.3.12a.1957 / Genes Dev / Bicaudal-D, a Drosophila gene involved in developmental asymmetry: localized transcript accumulation in ovaries and sequence similarity to myosin heavy chain tail domains by Suter (1989)
10.1016/0092-8674(91)90365-6 / Cell / Requirement for phosphorylation and localization of the Bicaudal-D protein in Drosophila oocyte differentiation by Suter (1991)
10.1242/dev.118.4.1169 / Development / A central role for microtubules in the differentiation of Drosophila oocytes by Theurkauf (1993)
10.1016/0014-4827(85)90120-X / Exp. Cell Res / F-actin rings are associated with the ring canals of the Drosophila egg chamber by Warn (1985)
10.1016/0092-8674(89)90611-9 / Cell / Structure of the Drosophila BicaudalD protein and its role in localizing the posterior determinant nanos by Wharton (1989)
{'key': '2023120300564040300_DEVELOP_120_5_1233C28', 'article-title': 'Looking at embryos', 'volume-title': 'In Drosophila, a Practical Approach', 'author': 'Wieschaus', 'year': '1986'} / In Drosophila, a Practical Approach / Looking at embryos by Wieschaus (1986)
10.1016/0012-1606(79)90241-0 / Dev. Biol / The development and function of the female germline in Drosophila melanogaster, a cell lineage study by Wieschaus (1979)
10.1242/dev.117.4.1223 / Development / Analysis of genetic mosaics in developing and adult Drosophila tissues by Xu (1993)
10.1101/gad.6.12b.2443 / Genes Dev / hu-li tai shao, a gene required for ring canal formation during Drosophila oogenesis, encodes a homolog of adducin by Yue (1992)

Dates

Type	When
Created	4 years, 4 months ago (April 25, 2021, 10:01 p.m.)
Deposited	1 year, 8 months ago (Dec. 2, 2023, 7:57 p.m.)
Indexed	1 year ago (Aug. 6, 2024, 3:58 a.m.)
Issued	31 years, 3 months ago (May 1, 1994)
Published	31 years, 3 months ago (May 1, 1994)
Published Online	31 years, 3 months ago (May 1, 1994)
Published Print	31 years, 3 months ago (May 1, 1994)

Funders 0

None

BibTeX

@article{Ran_1994, title={Null alleles reveal novel requirements for Bic-D during Drosophila oogenesis and zygotic development}, volume={120}, ISSN={1477-9129}, url={http://dx.doi.org/10.1242/dev.120.5.1233}, DOI={10.1242/dev.120.5.1233}, number={5}, journal={Development}, publisher={The Company of Biologists}, author={Ran, Bing and Bopp, Rita and Suter, Beat}, year={1994}, month=may, pages={1233–1242} }

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