DOI: 10.1242/dev.120.3.473. Cytosolic interaction between deltex and Notch ankyrin repeats implicates deltex in the Notch signaling pathway

Cytosolic interaction between deltex and Notch ankyrin repeats implicates deltex in the Notch signaling pathway

10.1242/dev.120.3.473

Crossref journal-article

The Company of Biologists

Development (237)

Abstract

ABSTRACT Genetic data from Drosophila have suggested a functional relationship between the novel cytoplasmic protein encoded by the deltex locus and the transmembrane receptor encoded by Notch. We have demonstrated a direct interaction between these proteins from expression studies conducted in cultured cells, in yeast, and in the imaginal wing disc. deltex binds specifically to the Notch ankyrin repeats, a region that is crucial for Notch signaling and that constitutes the most conserved domain among Notch family members. In addition, we present a new Notch allele, Nsu42c, that is associated with a missense mutation within the fifth ankyrin repeat. In addition to representing a new class of viable Notch allele, this mutation behaves similarly to mutations of deltex and further implicates the ankyrin repeats in Notch function.

Bibliography

Diederich, R. J., Matsuno, K., Hing, H., & Artavanis-Tsakonas, S. (1994). Cytosolic interaction between deltex and Notch ankyrin repeats implicates deltex in the Notch signaling pathway. Development, 120(3), 473â481.

Authors 4

Robert J. Diederich (first)
Kenji Matsuno (additional)
Huey Hing (additional)
Spyros Artavanis-Tsakonas (additional)

References 65 Referenced 174

10.1016/0168-9525(91)90220-K / Trends Genet / Choosing a cell fate: a view from the Notch locus by Artavanis-Tsakonas (1991)
10.1016/S0021-9258(19)50333-7 / J. Biol. Chem / Ankyrins: Adaptors between diverse plasma membrane proteins and the cytoplasm by Bennett (1992)
10.1016/0968-0004(92)90321-Y / Trends Biochem. Sci / NF-κB and related proteins: Rel/dorsal homologies meet ankyrin-like repeats by Blank (1992)
10.1038/329651a0 / Nature / Similarity between cell-cycle genes of budding yeast and fission yeast and the Notch gene of Drosophila by Breeden (1987)
10.1093/nar/16.3.1043 / Nucl. Acids Res / Characterization and use of the Drosophila metallothionein promoter in cultured Drosophila melanogaster cells by Bunch (1988)
10.1093/genetics/136.2.585 / Genetics, in press / A member of the Notch group of interacting loci, deltex encodes a cytoplasmic basic protein by Busseau (1994)
10.1101/gad.3.8.1099 / Genes Dev / Notch is required for successive cell decisions in the developing retina by Cagan (1989)
10.1126/science.2402639 / Science / Xotch, the Xenopus homolog of Drosophila Notch by Coffman (1990)
10.1016/0092-8674(93)90247-N / Cell / Expression of an extracellular deletion of Xotch diverts cell fate in Xenopus embryos by Coffman (1993)
10.1016/0092-8674(91)90183-Y / Cell / A role for the Drosophila neurogenic genes in mesoderm differentiation by Corbin (1991)
10.1242/dev.119.2.377 / Development / The strawberry notch gene functions with Notch in common developmental pathways by Coyle-Thompson (1993)
10.1093/genetics/129.3.803 / Genetics / Two genetically and molecularly distinct functions involved in early neurogenesis reside within the Enhancer of split locus of Drosophila melanogaster by Delidakis (1991)
10.1016/0092-8674(91)90111-B / Cell / TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms by Ellisen (1991)
10.1083/jcb.113.3.657 / J. Cell Biol / Complex spatial and temporal regulation of Notch expression during embryonic and imaginal development of Drosophila: implications for Notch function by Fehon (1991)
10.1016/0092-8674(90)90534-L / Cell / Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF- homologous genes in Drosophila by Fehon (1990)
10.1101/gad.4.12a.2188 / Genes Dev / The gene Serrate encodes a putative EGF-like transmembrane protein essential for proper ectodermal development in Drosophila melanogaster by Fleming (1990)
10.1038/365555a0 / Nature / An activated Notch receptor blocks cell-fate commitment in the developing Drosophila eye by Fortini (1993)
10.1093/genetics/81.1.99 / Genetics / Negative complementation at the Notch locus of Drosophila melanogaster by Foster (1975)
10.1006/geno.1993.1055 / Genomics / Cloning, analysis, and chromosomal localization of Notch-1, a mouse homolog of Drosophila Notch by Franco del Amo (1993)
10.1242/dev.115.3.737 / Development / Expression pattern of Motch, a mouse homolog of Drosophila Notch, suggests an important role in early postimplantation mouse development by Franco del Amo (1992)
10.1016/0092-8674(92)90595-4 / Cell / cactus, a gene involved in dorsoventral pattern formation of Drosophila, is related to the IκB gene family of vertebrates by Geisler (1992)
10.1101/gad.7.3.441 / Genes Dev / Dosage- sensitive modifiers of Drosophila abl tyrosine kinase function: prospero, a regulator of axonal outgrowth, and disabled, a novel tyrosine kinase substrate by Gertler (1993)
10.1093/nar/20.6.1425 / Nucl. Acids Res / Improved method for high efficiency transformation of intact yeast cells by Gietz (1992)
10.1093/genetics/131.1.99 / Genetics / A genetic analysis of deltex and its interaction with the Notch locus in Drosophila melanogaster by Gorman (1992)
10.1016/0092-8674(92)90470-W / Cell / Making a difference: the role of cell- cell interactions in establishing separate identities for equivalent cells by Greenwald (1992)
{'key': '2023072009421034300_DEVELOP_120_3_473C26', 'volume-title': 'Antibodies: A Laboratory Manual. Cold Spring Harbor', 'author': 'Harlow', 'year': '1988'} / Antibodies: A Laboratory Manual. Cold Spring Harbor by Harlow (1988)
10.1002/j.1460-2075.1987.tb02664.x / EMBO J / The embryonic expression of the Notch locus of Drosophila melanogaster and the implications of point mutations in the extracellular EGF-like domain of the predicted protein by Hartley (1987)
10.1016/0092-8674(91)90263-X / Cell / The choice of cell fate in the epidermis of Drosophila by Heitzler (1991)
10.1242/dev.117.3.1113 / Development / Altered epidermal growth factor-like sequences provide evidence for a role of Notch as a receptor in cell fate decisions by Heitzler (1993)
10.1016/0168-9525(91)90254-F / Trends Genet / Drosophila abl and genetic redundancy in signal transduction by Hoffman (1991)
10.1101/gad.6.4.619 / Genes Dev / The functional domains of the Drosophila morphogen dorsal: evidence from the analysis of mutants by Isoda (1992)
10.1016/0092-8674(87)90123-1 / Cell / Mutations altering the structure of epidermal growth factor-like coding sequences at the Drosophila Notch locus by Kelly (1987)
10.1016/0092-8674(92)90596-5 / Cell / Characterization of the Drosophila cactus locus and analysis of interactions between cactus and dorsal proteins by Kidd (1992)
{'key': '2023072009421034300_DEVELOP_120_3_473C34', 'first-page': '3094', 'article-title': 'Sequence of the Notch locus of Drosophila melanogaster: relationship of the encoded protein to mammalian clotting and growth factors', 'volume': '6', 'author': 'Kidd', 'year': '1986', 'journal-title': 'Mol. Cell. Biol'} / Mol. Cell. Biol / Sequence of the Notch locus of Drosophila melanogaster: relationship of the encoded protein to mammalian clotting and growth factors by Kidd (1986)
10.1091/mbc.3.11.1199 / Molec. Biol. Cell / Molecular basis of loss- of-function mutations in the glp-1 gene of Caenorhabitis elegans by Kodoyianni (1992)
10.1083/jcb.121.3.631 / J. Cell Biol / Mouse Notch: expression in hair follicles correlates with cell fate determination by Kopan (1993)
10.1126/science.1876836 / Science / Identification of Ets- and Notch-related subunits in GA binding protein by LaMarco (1991)
10.1038/344036a0 / Nature / Analysis of cDNA for human erythrocyte ankyrin indicates a repeated structure with homology to tissue- differentiation and cell-cycle control proteins by Lux (1990)
10.1016/0962-8924(92)90084-Z / Trends Cell Biol / The ANK repeat: a ubiquitous motif involved in macromolecular recognition by Michaely (1992)
10.1101/gad.6.9.1654 / Genes Dev / Selective nuclear transport of the Drosophila morphogen dorsal can be established by a signaling pathway involving the transmembrane protein Toll and protein kinase A by Norris (1992)
10.1242/dev.109.1.167 / Development / Neurogenic and antineurogenic effects from modifications at the Notch locus by Palka (1990)
10.1093/genetics/81.1.121 / Genetics / Allelic negative complementation at the Abruptex locus of Drosophila melanogaster by Portin (1975)
10.1016/0092-8674(93)90423-N / Cell / Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor by Rebay (1993)
10.1016/0092-8674(91)90064-6 / Cell / Specific EGF repeats of Notch mediate interactions with Delta and Serrate: implications for Notch as a multifunctional receptor by Rebay (1991)
10.1128/jvi.66.4.2594-2599.1992 / J. Virol / Mouse mammary tumor gene int-3: a member of the Notch gene family transforms mammary epithelial cells by Robbins (1992)
10.1038/364632a0 / Nature / Control of cell fate in C. elegans by a GLP-1 peptide consisting of ankyrin repeats by Roehl (1993)
10.1016/0168-9525(91)90214-B / Trends Genet / Signal transduction and the fate of the R7 photoreceptor in Drosophila by Rubin (1991)
10.1016/0092-8674(81)90008-8 / Cell / Role of neurogenic genes in establishment of follicle cell fate and oocyte polarity during oogenesis in Drosophila by Ruohola (1991)
10.1016/0092-8674(89)90772-1 / Cell / The graded distribution of the dorsal morphogen is initiated by selective nuclear transport in Drosophila by Rushlow (1989)
10.1073/pnas.74.12.5463 / Proc. Natl. Acad. Sci. USA / DNA sequencing with chain-terminating inhibitors by Sanger (1977)
{'key': '2023072009421034300_DEVELOP_120_3_473C51', 'first-page': '353', 'article-title': 'Cell lines derived from late embryonic stages of Drosophila melanogaster', 'volume': '27', 'author': 'Schneider', 'year': '1972', 'journal-title': 'J. Embryol. Exp. Morph'} / J. Embryol. Exp. Morph / Cell lines derived from late embryonic stages of Drosophila melanogaster by Schneider (1972)
10.1126/science.1313187 / Science / Intercellular communication and cell-cell adhesion by Singer (1992)
10.1101/gad.4.10.1688 / Genes Dev / The Drosophila neurogenic locus mastermind encodes a nuclear protein unusually rich in amino acid homopolymers by Smoller (1990)
10.1038/ng1092-119 / Nature Genetics / Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins by Stifani (1992)
10.1016/0092-8674(93)90424-O / Cell / Intrinsic activity of the lin-12 and Notch intracellular domains in vivo by Struhl (1993)
10.1016/0012-1606(87)90239-9 / Dev. Biol / Neuronal differentiation in the Drosophila ommatidium by Tomlinson (1987)
10.1016/0092-8674(90)90801-K / Cell / Signal transduction by receptors with tyrosine kinase activity by Ullrich (1990)
10.3109/01677068509102325 / J. Neurogen / Genetic interactions in early neurogenesis of Drosophila melanogaster by Vässin (1985)
10.1242/dev.113.1.199 / Development / A homolog of Drosophila Notch expressed during mammalian development by Weinmaster (1991)
10.1242/dev.116.4.931 / Development / Notch2: a second mammalian Notch gene by Weinmaster (1992)
10.1016/0092-8674(85)90229-6 / Cell / Nucleotide sequence from the neurogenic locus Notch implies a gene product that shares homology with proteins containing EGF-like repeats by Wharton (1985)
10.1093/genetics/126.3.665 / Genetics / deltex, a locus interacting with the neurogenic genes, Notch, Delta and mastermind in Drosophila melanogaster by Xu (1990)
10.1242/dev.115.4.913 / Development / The involvement of the Notch locus in Drosophila oogenesis by Xu (1992)
10.1101/gad.4.3.464 / Genes Dev / The Notch locus and the genetic circuitry involved in early Drosophila neurogenesis by Xu (1990)
10.1016/0092-8674(93)90662-A / Cell / Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites by Zervos (1993)

Dates

Type	When
Created	4 years, 4 months ago (April 25, 2021, 9:33 p.m.)
Deposited	2 years, 1 month ago (July 20, 2023, 5:50 a.m.)
Indexed	1 month, 3 weeks ago (July 1, 2025, 9:50 a.m.)
Issued	31 years, 5 months ago (March 1, 1994)
Published	31 years, 5 months ago (March 1, 1994)
Published Online	31 years, 5 months ago (March 1, 1994)
Published Print	31 years, 5 months ago (March 1, 1994)

Funders 0

None

BibTeX

@article{Diederich_1994, title={Cytosolic interaction between deltex and Notch ankyrin repeats implicates deltex in the Notch signaling pathway}, volume={120}, ISSN={1477-9129}, url={http://dx.doi.org/10.1242/dev.120.3.473}, DOI={10.1242/dev.120.3.473}, number={3}, journal={Development}, publisher={The Company of Biologists}, author={Diederich, Robert J. and Matsuno, Kenji and Hing, Huey and Artavanis-Tsakonas, Spyros}, year={1994}, month=mar, pages={473–481} }

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      "author": "Bennett",
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