DOI: 10.1242/dev.120.2.463. Mesoderm induction by activin requires FGF-mediated intracellular signals

Mesoderm induction by activin requires FGF-mediated intracellular signals

10.1242/dev.120.2.463

Crossref journal-article

The Company of Biologists

Development (237)

Abstract

ABSTRACT We have examined the role of FGF signaling during activin-mediated mesoderm induction in Xenopus. Using dominant inhibitory mutants of FGF signal transducers to disrupt the FGF-signaling pathway at the plasma membrane or in the cytosol prevents animal cap blastomeres from expressing several mesodermal markers in response to exogenous activin. Dominant inhibitory mutants of the FGF receptor, c-ras or c-raf inhibit the ability of activin to induce molecular markers of both dorsal and ventral mesoderm including Xbra, Mix1 and Xnot. Some transcriptional responses to activin such as goosecoid and Xwnt8 are inhibited less effectively than others, however, suggesting that there may differing requirements for an FGF signal in the responses of mesoderm-specific genes to activin induction. Despite the requirement for this signaling pathway during activin induction, downstream components of this pathway are not activated in response to activin, suggesting that activin does not signal directly through this pathway.

Bibliography

LaBonne, C., & Whitman, M. (1994). Mesoderm induction by activin requires FGF-mediated intracellular signals. Development, 120(2), 463â472.

Authors 2

Carole LaBonne (first)
Malcolm Whitman (additional)

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Dates

Type	When
Created	4 years, 4 months ago (April 23, 2021, 2:46 p.m.)
Deposited	2 years, 1 month ago (July 20, 2023, 5:46 a.m.)
Indexed	1 month, 4 weeks ago (July 2, 2025, 2:48 p.m.)
Issued	31 years, 7 months ago (Feb. 1, 1994)
Published	31 years, 7 months ago (Feb. 1, 1994)
Published Online	31 years, 7 months ago (Feb. 1, 1994)
Published Print	31 years, 7 months ago (Feb. 1, 1994)

Funders 0

None

BibTeX

@article{LaBonne_1994, title={Mesoderm induction by activin requires FGF-mediated intracellular signals}, volume={120}, ISSN={1477-9129}, url={http://dx.doi.org/10.1242/dev.120.2.463}, DOI={10.1242/dev.120.2.463}, number={2}, journal={Development}, publisher={The Company of Biologists}, author={LaBonne, Carole and Whitman, Malcolm}, year={1994}, month=feb, pages={463–472} }

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