DOI: 10.1242/dev.119.1.247. Mouse <i>Wnt</i> genes exhibit discrete domains of expression in the early embryonic CNS and limb buds

Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds

10.1242/dev.119.1.247

Crossref journal-article

The Company of Biologists

Development (237)

Abstract

ABSTRACT Mutation and expression studies have implicated the Wnt gene family in early developmental decision making in vertebrates and flies. In a detailed comparative analysis, we have used in situ hybridization of 8.0- to 9.5-day mouse embryos to characterize expression of all ten published Wnt genes in the central nervous system (CNS) and limb buds. Seven of the family members show restricted expression patterns in the brain. At least three genes (Wnt-3, Wnt-3a, and Wnt-7b) exhibit sharp bound-aries of expression in the forebrain that may predict sub-divisions of the region later in development. In the spinal cord, Wnt-1, Wnt-3, and Wnt-3a are expressed dorsally, Wnt-5a, Wnt-7a, and Wnt-7b more ventrally, and Wnt-4 both dorsally and in the floor plate. In the forelimb primordia, Wnt-3, Wnt-4, Wnt-6 and Wnt-7b are expressed fairly uniformly throughout the limb ectoderm. Wnt-5a RNA is distributed in a proximal to distal gradient through the limb mesenchyme and ectoderm. Along the limb’s dorsal-ventral axis, Wnt-5a is expressed in the ventral ectoderm and Wnt-7a in the dorsal ectoderm. We discuss the significance of these patterns of restricted and partially overlapping domains of expression with respect to the putative function of Wnt signalling in early CNS and limb development.

Bibliography

Parr, B. A., Shea, M. J., Vassileva, G., & McMahon, A. P. (1993). Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds. Development, 119(1), 247â261.

Authors 4

Brian A. Parr (first)
Martin J. Shea (additional)
Galya Vassileva (additional)
Andrew P. McMahon (additional)

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Dates

Type	When
Created	4 years, 4 months ago (April 25, 2021, 9:19 p.m.)
Deposited	1 year, 8 months ago (Dec. 2, 2023, 5:35 p.m.)
Indexed	6 days, 21 hours ago (Aug. 20, 2025, 9:05 a.m.)
Issued	31 years, 11 months ago (Sept. 1, 1993)
Published	31 years, 11 months ago (Sept. 1, 1993)
Published Online	31 years, 11 months ago (Sept. 1, 1993)
Published Print	31 years, 11 months ago (Sept. 1, 1993)

Funders 0

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BibTeX

@article{Parr_1993, title={Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds}, volume={119}, ISSN={1477-9129}, url={http://dx.doi.org/10.1242/dev.119.1.247}, DOI={10.1242/dev.119.1.247}, number={1}, journal={Development}, publisher={The Company of Biologists}, author={Parr, Brian A. and Shea, Martin J. and Vassileva, Galya and McMahon, Andrew P.}, year={1993}, month=sep, pages={247–261} }

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  "abstract": "<jats:title>ABSTRACT</jats:title>\n               <jats:p>Mutation and expression studies have implicated the Wnt gene family in early developmental decision making in vertebrates and flies. In a detailed comparative analysis, we have used in situ hybridization of 8.0- to 9.5-day mouse embryos to characterize expression of all ten published Wnt genes in the central nervous system (CNS) and limb buds. Seven of the family members show restricted expression patterns in the brain. At least three genes (Wnt-3, Wnt-3a, and Wnt-7b) exhibit sharp bound-aries of expression in the forebrain that may predict sub-divisions of the region later in development. In the spinal cord, Wnt-1, Wnt-3, and Wnt-3a are expressed dorsally, Wnt-5a, Wnt-7a, and Wnt-7b more ventrally, and Wnt-4 both dorsally and in the floor plate. In the forelimb primordia, Wnt-3, Wnt-4, Wnt-6 and Wnt-7b are expressed fairly uniformly throughout the limb ectoderm. Wnt-5a RNA is distributed in a proximal to distal gradient through the limb mesenchyme and ectoderm. Along the limb\u2019s dorsal-ventral axis, Wnt-5a is expressed in the ventral ectoderm and Wnt-7a in the dorsal ectoderm. We discuss the significance of these patterns of restricted and partially overlapping domains of expression with respect to the putative function of Wnt signalling in early CNS and limb development.</jats:p>",
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