DOI: 10.1242/dev.117.2.571. Pattern formation in a secondary field: a hierarchy of regulatory genes subdivides the developing <i>Drosophila</i> wing disc into discrete subregions

Pattern formation in a secondary field: a hierarchy of regulatory genes subdivides the developing Drosophila wing disc into discrete subregions

10.1242/dev.117.2.571

Crossref journal-article

The Company of Biologists

Development (237)

Abstract

ABSTRACT The legs and wings of insects and vertebrates develop from secondary embryonic fields that arise after the primary body axes have been established. In order to understand how the insect imaginal wing field is patterned, we have examined in detail the temporal and spatial expression patterns of, and epistatic relationships between, four key regulatory genes that are specifically required for wing formation in Drosophila. The wing less protein, in a role surprisingly distinct from its embryonic segment polarity function, appears to be the earliest-acting member of the hierarchy and crucial fordistinguishing the notum/wing subfields, and for the compartmentalization of the dorsal and ventral wing surfaces. The wingless product is required to restrict the expression of the apterous gene to dorsal cells and to promote the expression of the vestigial and scalloped genes that demarcate the wing primordia and act in concert to promote morphogenesis.

Bibliography

Williams, J. A., Paddock, S. W., & Carroll, S. B. (1993). Pattern formation in a secondary field: a hierarchy of regulatory genes subdivides the developing Drosophila wing disc into discrete subregions. Development, 117(2), 571â584.

Authors 3

Jim A. Williams (first)
Stephen W. Paddock (additional)
Sean B. Carroll (additional)

References 36 Referenced 257

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{'key': '2024121722414056500_DEVELOP_117_2_571C5', 'first-page': '229', 'article-title': 'Pattern formation in imaginal discs', 'volume-title': 'In ‘The genetics and biology of Drosophila', 'author': 'Bryant', 'year': '1978'} / In ‘The genetics and biology of Drosophila / Pattern formation in imaginal discs by Bryant (1978)
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10.1101/gad.6.3.367 / GenesDev / The scalloped gene encodes a novel, evolutionarily conserved transcription factor required for sensory organ differentiation in Drosophila by Campbell (1992)
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10.1016/0012-1606(76)90052-X / Dev. Biol / Developmental compartmentalization in the dorsal mesothoracic disc of Drosophila by Garcia-Bellido (1976)
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10.1016/0012-1606(81)90234-7 / Dev. Biol / Mutations causing pattern deficiencies and duplications in the imaginal wing disc of Drosophila melanogaster by James (1981)
{'key': '2024121722414056500_DEVELOP_117_2_571C14', 'article-title': 'Morphogenesis and compartments in Drosophila', 'volume-title': 'In ‘Pattern Formation: A Primer in Developmental Biology’ (Malacinski, G. M. and Bryant, S. V., Eds) Collier Macmillan Publishers, London', 'author': 'Karlsson', 'year': '1984'} / In ‘Pattern Formation: A Primer in Developmental Biology’ (Malacinski, G. M. and Bryant, S. V., Eds) Collier Macmillan Publishers, London / Morphogenesis and compartments in Drosophila by Karlsson (1984)
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Dates

Type	When
Created	4 years, 4 months ago (April 25, 2021, 9:14 p.m.)
Deposited	8 months, 2 weeks ago (Dec. 17, 2024, 5:42 p.m.)
Indexed	2 months ago (July 1, 2025, 7:24 p.m.)
Issued	32 years, 7 months ago (Feb. 1, 1993)
Published	32 years, 7 months ago (Feb. 1, 1993)
Published Online	32 years, 7 months ago (Feb. 1, 1993)
Published Print	32 years, 7 months ago (Feb. 1, 1993)

Funders 0

None

BibTeX

@article{Williams_1993, title={Pattern formation in a secondary field: a hierarchy of regulatory genes subdivides the developing Drosophila wing disc into discrete subregions}, volume={117}, ISSN={1477-9129}, url={http://dx.doi.org/10.1242/dev.117.2.571}, DOI={10.1242/dev.117.2.571}, number={2}, journal={Development}, publisher={The Company of Biologists}, author={Williams, Jim A. and Paddock, Stephen W. and Carroll, Sean B.}, year={1993}, month=feb, pages={571–584} }

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