DOI: 10.1242/dev.117.2.493. Implications of dynamic patterns of Delta and Notch expression for cellular interactions during <i>Drosophila</i> development

Implications of dynamic patterns of Delta and Notch expression for cellular interactions during Drosophila development

10.1242/dev.117.2.493

Crossref journal-article

The Company of Biologists

Development (237)

Abstract

ABSTRACT Delta and Notch function are required for cell fate specification in numerous tissues during embryonic and postembryonic Drosophila development. Delta is expressed by all members of interacting cell populations within which fates are being specified and is subsequently down-regulated as cells stably adopt particular fates. Multiphasic expression in the derivatives of many germ layers implies successive requirements for Delta function in a number of tissues. At the cellular level, Delta and Notch expression are generally coincident within developing tissues. At the subcellular level, Delta and Notch are localized in apparent endocytic vesicles during down-regulation from the surfaces of interacting cells, implying an interaction consistent with their proposed roles as signal and receptor in cellular interactions during development.

Bibliography

Kooh, P. J., Fehon, R. G., & Muskavitch, M. A. T. (1993). Implications of dynamic patterns of Delta and Notch expression for cellular interactions during Drosophila development. Development, 117(2), 493â507.

Authors 3

Pamela J. Kooh (first)
Richard G. Fehon (additional)
Marc A. T. Muskavitch (additional)

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Dates

Type	When
Created	4 years, 4 months ago (April 25, 2021, 9:13 p.m.)
Deposited	8 months, 2 weeks ago (Dec. 17, 2024, 5:42 p.m.)
Indexed	3 months, 2 weeks ago (May 13, 2025, 2:45 p.m.)
Issued	32 years, 7 months ago (Feb. 1, 1993)
Published	32 years, 7 months ago (Feb. 1, 1993)
Published Online	32 years, 7 months ago (Feb. 1, 1993)
Published Print	32 years, 7 months ago (Feb. 1, 1993)

Funders 0

None

BibTeX

@article{Kooh_1993, title={Implications of dynamic patterns of Delta and Notch expression for cellular interactions during Drosophila development}, volume={117}, ISSN={1477-9129}, url={http://dx.doi.org/10.1242/dev.117.2.493}, DOI={10.1242/dev.117.2.493}, number={2}, journal={Development}, publisher={The Company of Biologists}, author={Kooh, Pamela J. and Fehon, Richard G. and Muskavitch, Marc A. T.}, year={1993}, month=feb, pages={493–507} }

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