DOI: 10.1242/dev.115.3.791. Developmental regulation of chromatin composition during mouse embryogenesis: somatic histone H1 is first detectable at the 4-cell stage

Developmental regulation of chromatin composition during mouse embryogenesis: somatic histone H1 is first detectable at the 4-cell stage

10.1242/dev.115.3.791

Crossref journal-article

The Company of Biologists

Development (237)

Abstract

ABSTRACT We have examined the distribution of histone H1 in oocytes and preimplantation embryos of the mouse, using a polyclonal antibody raised against the histone H1 sub-types present in somatic cells. Immunofluorescence and immunoblotting analyses failed to detect somatic histone H1 in germinal vesicle (GV)-stage oocytes. In contrast, somatic histone H1 was detectable by immunofluorescence in the nuclei of GV oocytes previously injected with histone H1 as well as the nuclei of ovarian granulosa cells, and by immunoblotting in 8-cell embryos. 1- and 2-cell embryos examined by immuofluorescence did not contain detectable somatic histone H1. At the early 4-cell stage (54–56 hours post-hCG), 5 of 52 embryos contained somatic histone H1 in one or more nuclei. By the late 4-cell stage (66–68 hours post-hCG), however, 58 of 62 embryos contained somatic histone H1. In 8-cell embryos, morulae and blastocysts, all nuclei contained somatic histone H1 in every case. When embryos were exposed to the transcriptional inhibitor, -amanitin, beginning at the late 2-cell stage, they cleaved to the 4-cell stage but fewer than 10% developed histone H1 immunoreactivity. When treatment began at the early 4-cell stage, the embryos that remained at the 4-cell stage in the presence of the drug developed histone H1 immunoreactivity in half of the cases. Embryos that reached the 5-to 8-cell stage in the presence of the drug developed histone H1 immunoreactivity in every case. The protein synthesis inhibitor, puromycin, prevented development of histone H1 immunoreactivity in most embryos when added either at the late 2-cell or early 4-cell stage. When embryos were exposed to the DNA replication inhibitor, aphidicolin, beginning at the late 2-cell stage, they cleaved to the 4-cell stage, but developed only a very weak histone H1 immunoreactivity. These results indicate that oocytes and 1- and 2-cell embryos contain little or no somatic histone H1, which may imply that these cells contain immunologically distinct histone H1 subtypes. The somatic subtypes first appear at the 4-cell stage, through a process requiring embryonic transcription and DNA replication during the third cell cycle. These results suggest that the deposition of somatic histone H1 on chromatin is developmentally regulated during mouse embryogenesis.

Bibliography

Clarke, H. J., Oblin, C., & Bustin, M. (1992). Developmental regulation of chromatin composition during mouse embryogenesis: somatic histone H1 is first detectable at the 4-cell stage. Development, 115(3), 791â799.

Authors 3

Hugh J. Clarke (first)
Colette Oblin (additional)
Michael Bustin (additional)

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Dates

Type	When
Created	4 years, 4 months ago (April 25, 2021, 8:56 p.m.)
Deposited	1 year, 8 months ago (Dec. 2, 2023, 5:25 p.m.)
Indexed	3 months, 3 weeks ago (May 6, 2025, 5:53 a.m.)
Issued	33 years, 2 months ago (July 1, 1992)
Published	33 years, 2 months ago (July 1, 1992)
Published Online	33 years, 2 months ago (July 1, 1992)
Published Print	33 years, 2 months ago (July 1, 1992)

Funders 0

None

BibTeX

@article{Clarke_1992, title={Developmental regulation of chromatin composition during mouse embryogenesis: somatic histone H1 is first detectable at the 4-cell stage}, volume={115}, ISSN={1477-9129}, url={http://dx.doi.org/10.1242/dev.115.3.791}, DOI={10.1242/dev.115.3.791}, number={3}, journal={Development}, publisher={The Company of Biologists}, author={Clarke, Hugh J. and Oblin, Colette and Bustin, Michael}, year={1992}, month=jul, pages={791–799} }

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