DOI: 10.1242/dev.115.1.21. <i>engrailed</i>expression in the anterior lineage compartment of the developing wing blade of<i>Drosophila</i>

engrailedexpression in the anterior lineage compartment of the developing wing blade ofDrosophila

10.1242/dev.115.1.21

Crossref journal-article

The Company of Biologists

Development (237)

Abstract

AbstractThe developing wing of Drosophila melanogaster was examined at larval and pupal stages of development to determine whether the anterior-posterior lineage boundary, as identified by lineage restrictions, was congruent with the boundaries defined by the expression of posterior-specific (engrailed, inverted), and anterior-specific (cubitus interruptus-D) genes. The lineage boundary was identified by marking mitotic recombinant clones, using an enhancer trap line with ubiquitous β-gal expression in imaginai tissues; clones of +/+ cells were identified by their lack of β-gal expression. Domains of gene expression were localized using antibodies and gene specific lacZ constructs. Surprisingly, it was found that engrailed expression extended a small distance into the anterior lineage compartment of the wing blade, as identified with anti-en/tnv mAh, anti-en polyclonal antiserum, or an en-promoter-lacZ insert, ryxho25. This anterior expression was not present in early third instar discs, but appeared during subsequent larval and pupal development. In contrast, the expression of cubitus interruptus-D, as identified using the ci-Dplac insert, appeared to be limited to the anterior lineage compartment. Thus, en expression is not limited to cells from the posterior lineage compartment, and en and ci-D activities can overlap in a region just anterior to the lineage compartment boundary in the developing wing. The lineage boundary could also be identified by a line of aligned cells in the prospective wing blade region of wandering third instar discs. A decapeniaplegic-lacZ construct was expressed in a stripe several cells anterior to the lineage boundary, and did not define or overlap into the posterior lineage compartment.

Bibliography

Blair, S. S. (1992). engrailedexpression in the anterior lineage compartment of the developing wing blade ofDrosophila. Development, 115(1), 21â33.

Authors 1

Seth S. Blair (first)

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Dates

Type	When
Created	4 years, 4 months ago (April 25, 2021, 9:02 p.m.)
Deposited	1 year, 9 months ago (Nov. 2, 2023, 2:33 p.m.)
Indexed	1 month, 3 weeks ago (July 2, 2025, 2:48 p.m.)
Issued	33 years, 3 months ago (May 1, 1992)
Published	33 years, 3 months ago (May 1, 1992)
Published Online	33 years, 3 months ago (May 1, 1992)
Published Print	33 years, 3 months ago (May 1, 1992)

Funders 0

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BibTeX

@article{Blair_1992, title={engrailedexpression in the anterior lineage compartment of the developing wing blade ofDrosophila}, volume={115}, ISSN={1477-9129}, url={http://dx.doi.org/10.1242/dev.115.1.21}, DOI={10.1242/dev.115.1.21}, number={1}, journal={Development}, publisher={The Company of Biologists}, author={Blair, Seth S.}, year={1992}, month=may, pages={21–33} }

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