DOI: 10.1242/dev.115.1.11. <i>c-ros:</i> the vertebrate homolog of the <i>sevenless</i> tyrosine kinase receptor is tightly regulated during organogenesis in mouse embryonic development*

c-ros: the vertebrate homolog of the sevenless tyrosine kinase receptor is tightly regulated during organogenesis in mouse embryonic development*

10.1242/dev.115.1.11

Crossref journal-article

The Company of Biologists

Development (237)

Abstract

Abstract The c-ros proto-oncogene is the vertebrate homologue of the Drosophila sevenless tyrosine kinase receptor. Examination of c-ros mRNA transcripts in the mouse embryo reveals a stringent pattern of expression. Only kidney, intestine and lung exhibit ros-specific RNA using sensitive techniques such as RNAse protection and in situ hybridization. The temporal and spatial arrangement of c-ros transcripts is coincident with the phenotypic induction and proliferation of epithelium during organogenesis of the kidney and intestine. The data provide evidence for a role of c-ros in the obligate cell-cell interactions that characterize the morphogenic induction and proliferation of epithelial cells in the kidney, intestine and lung. The c-ros tyrosine kinase receptor may provide a signal transduction pathway for epithelial-mesenchymal interactions.

Bibliography

Tessarollo, L., Nagarajan, L., & Parada, L. F. (1992). c-ros: the vertebrate homolog of the sevenless tyrosine kinase receptor is tightly regulated during organogenesis in mouse embryonic development*. Development, 115(1), 11â20.

Authors 3

Lino Tessarollo (first)
Lalitha Nagarajan (additional)
Luis F. Parada (additional)

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Dates

Type	When
Created	4 years, 4 months ago (April 25, 2021, 9:01 p.m.)
Deposited	2 years, 3 months ago (May 3, 2023, 11:47 a.m.)
Indexed	1 year, 3 months ago (May 9, 2024, 6:33 p.m.)
Issued	33 years, 3 months ago (May 1, 1992)
Published	33 years, 3 months ago (May 1, 1992)
Published Online	33 years, 3 months ago (May 1, 1992)
Published Print	33 years, 3 months ago (May 1, 1992)

Funders 0

None

BibTeX

@article{Tessarollo_1992, title={c-ros: the vertebrate homolog of the sevenless tyrosine kinase receptor is tightly regulated during organogenesis in mouse embryonic development*}, volume={115}, ISSN={1477-9129}, url={http://dx.doi.org/10.1242/dev.115.1.11}, DOI={10.1242/dev.115.1.11}, number={1}, journal={Development}, publisher={The Company of Biologists}, author={Tessarollo, Lino and Nagarajan, Lalitha and Parada, Luis F.}, year={1992}, month=may, pages={11–20} }

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