DOI: 10.1242/dev.114.4.947. A temporally regulated, diffusible activity is required for rod photoreceptor development in vitro

A temporally regulated, diffusible activity is required for rod photoreceptor development in vitro

10.1242/dev.114.4.947

Crossref journal-article

The Company of Biologists

Development (237)

Abstract

Abstract The retina is a relatively simple and well-characterized CNS structure in which cell-cell interactions have been hypothesized to influence cell type determination. By manipulating cell density in serum-free cultures we show that rat rod photoreceptor development requires a diffusible activity produced by neonatal retinal cells. This effect is not mediated by changes in cell survival or mitosis. Production of the rod promoting activity varies with developmental stage and is temporally correlated with the timing of rod generation in vivo. In low density cultures, which do not support rod development, an increased fraction of cells stain with an antibody specific for another retinal neuron, the bipolar cell. Thus, the diffusible rod promoting activity may influence cell fate determination, and not only terminal differentiation. These results provide an approach for the molecular characterization of developmentally important signals in the vertebrate retina.

Bibliography

Altshuler, D., & Cepko, C. (1992). A temporally regulated, diffusible activity is required for rod photoreceptor development in vitro. Development, 114(4), 947â957.

Authors 2

David Altshuler (first)
Connie Cepko (additional)

References 36 Referenced 140

10.1126/science.2911751 / Science / Plasticity and differentiation of embryonic retinal cells after terminal mitosis by Adler (1989)
10.1016/0006-8993(87)91644-1 / Brain Res. / Histiotypic organization and cell differentiation in rat retinal reaggregate cultures by Akagawa (1987)
{'key': '2024022606472211600_DEVELOP_114_4_947C3', 'article-title': 'Specification of cell type in the vertebrate retina', 'volume-title': 'Development of the Visual System,', 'author': 'Altshuler', 'year': '1991'} / Development of the Visual System, / Specification of cell type in the vertebrate retina by Altshuler (1991)
10.1002/ar.1090520203 / Anat. Rec. / The prenatal growth of the albino rat by Angulo (1932)
10.1016/0014-5793(88)80490-3 / Febs. Lett. / Isolation and analysis of the mouse opsin gene by Baehr (1988)
10.1016/0896-6273(90)90093-U / Neuron / The role of cell-cell interaction in the development of the Drosophila visual system by Banerjee (1990)
10.1101/SQB.1983.048.01.089 / Cold Spring Harbor Symp. Quant. Biol. / Monoclonal antibodies that label discrete cell types in the mammalian nervous system by Barnstable (1983)
10.1073/pnas.86.17.6474 / Proc. Natl. Acad. Sci. USA / Structure and expression of the murine retinoblastoma gene and characterization of its encoded protein by Bernards (1989)
10.1016/0003-2697(87)90021-2 / Analyt. Biochem. / Single-step method of RNA isolation by acid guanidinium triocyanate-phenol-chloroform extraction by Chomczynski (1987)
10.1007/BF01258151 / J. Neurocytol. / The subcellular localization of rat photoreceptor specific antigens by Fekete (1983)
10.1016/0896-6273(91)90168-Y / Neuron / Cerebellar granule cell neurogenesis is regulated by cell-cell interactions in vitro by Gao (1991)
10.1016/0042-6822(81)90022-2 / Virology / Cell cycle dependence of synthesis of unintegrated viral DNA in mouse cells newly infected with murine leukemia virus by Hard (1981)
10.1016/0896-6273(88)90205-X / Neuron / Cellular determination in the Xenopus retina is independent of lineage and birth date by Holt (1988)
10.1242/dev.110.4.1115 / Development / Time course of opsin expression in developing rod photoreceptors by Knight (1990)
10.1038/352207a0 / Nature / Interaction of bride of sevenless membrane-bound ligand and the sevenless tyrosine-kinase receptor by Krfimer (1991)
10.1016/0896-6273(90)90110-2 / Neuron / Analysis of the cell-cell interactions that control type-2 astrocyte development in vitro by Lillien (1990)
10.1016/0896-6273(88)90179-1 / Neuron / Type-2 astrocyte development in rat brain cultures is initiated by a CNTF-like protein produced by type-1 astroctyes by Lillien (1988)
{'key': '2024022606472211600_DEVELOP_114_4_947C18', 'first-page': '143', 'article-title': 'The development of the external form of the rat with observations on the origin of the extraembryonic coelom and foetal membranes', 'volume': '43', 'author': 'Long', 'year': '1936', 'journal-title': 'University of California Publications in Zoology'} / University of California Publications in Zoology / The development of the external form of the rat with observations on the origin of the extraembryonic coelom and foetal membranes by Long (1936)
10.1126/science.254.5029.282 / Science / Cell cycle dependence of laminar determination in developing neocortex by McConnell (1991)
10.1126/science.1672778 / Science / Pattern formation during animal development by Melton (1991)
10.1016/0304-3940(88)90025-0 / Neurosci. Lett. / Dopamine cells and rod bipolar cells contain protein kinase C-like immunoreactivity in some vertebrate retinas by Negishi (1988)
10.1016/0165-3806(87)90177-5 / Dev. Brain Res. / Paradoxical induction of dopaminergic cells following intravitreal injection of high doses of 6-hydroxydopamine in juvenile carp retina by Negishi (1987)
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10.1016/0896-6273(90)90136-4 / Neuron / Lineageindependent determination of cell type in the embryonic mouse retina by Turner (1990)
10.1016/0092-8674(77)90047-2 / Cell / Cellular functions are required for the synthesis and integration of avian sarcoma virus-specific DNA by Varmus (1977)
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Dates

Type	When
Created	4 years, 4 months ago (April 23, 2021, 2:26 p.m.)
Deposited	1 year, 6 months ago (Feb. 26, 2024, 1:47 a.m.)
Indexed	2 months, 3 weeks ago (June 11, 2025, 8:34 p.m.)
Issued	33 years, 5 months ago (April 1, 1992)
Published	33 years, 5 months ago (April 1, 1992)
Published Online	33 years, 5 months ago (April 1, 1992)
Published Print	33 years, 5 months ago (April 1, 1992)

Funders 0

None

BibTeX

@article{Altshuler_1992, title={A temporally regulated, diffusible activity is required for rod photoreceptor development in vitro}, volume={114}, ISSN={1477-9129}, url={http://dx.doi.org/10.1242/dev.114.4.947}, DOI={10.1242/dev.114.4.947}, number={4}, journal={Development}, publisher={The Company of Biologists}, author={Altshuler, David and Cepko, Connie}, year={1992}, month=apr, pages={947–957} }

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