DOI: 10.1242/dev.112.1.161. The surface glycoprotein Thy-1 is excluded from growing axons during development: a study of the expression of Thy-1 during axogenesis in hippocampus and hindbrain

The surface glycoprotein Thy-1 is excluded from growing axons during development: a study of the expression of Thy-1 during axogenesis in hippocampus and hindbrain

10.1242/dev.112.1.161

Crossref journal-article

The Company of Biologists

Development (237)

Abstract

ABSTRACTThy-1 is a developmentally regulated surface glycoprotein expressed on a number of tissues, including nerve where it is a major surface component of mature neurons. During neural development in the rat and mouse, expression of Thy-1 protein does not necessarily follow appearance of its mRNA, but additionally requires completion of the initial phase of axonal growth. Where there is a substantial lag phase between initial elongation and final axonal outgrowth into a terminal field (e.g. pontine projection to the cerebellum), Thy-1 protein appears at the cell body and dendrites of the neurons, but is excluded from their axons until the terminal phase of axonal growth is completed. In the more complex case of the vestibular ganglion neurons, whose axons project primarily to the vestibular nuclei in the brainstem before birth, and then 1–2 weeks later into the cerebellum, Thy-1 enters the proximal axonal regions where growth is completed, but not the distal growing ends. Thus complex controls govern the initial expression and distribution of Thy-1 so as to exclude it from growing regions of axons.

Bibliography

Xue, G. P., Rivero, B. P., & Morris, R. J. (1991). The surface glycoprotein Thy-1 is excluded from growing axons during development: a study of the expression of Thy-1 during axogenesis in hippocampus and hindbrain. Development, 112(1), 161â176.

Authors 3

G. P. Xue (first)
B. Pliego Rivero (additional)
R. J. Morris (additional)

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Dates

Type	When
Created	4 years, 4 months ago (April 25, 2021, 9:40 p.m.)
Deposited	1 year ago (Aug. 29, 2024, 6:49 a.m.)
Indexed	5 months, 2 weeks ago (March 19, 2025, 9:53 a.m.)
Issued	34 years, 4 months ago (May 1, 1991)
Published	34 years, 4 months ago (May 1, 1991)
Published Online	34 years, 4 months ago (May 1, 1991)
Published Print	34 years, 4 months ago (May 1, 1991)

Funders 0

None

BibTeX

@article{Xue_1991, title={The surface glycoprotein Thy-1 is excluded from growing axons during development: a study of the expression of Thy-1 during axogenesis in hippocampus and hindbrain}, volume={112}, ISSN={1477-9129}, url={http://dx.doi.org/10.1242/dev.112.1.161}, DOI={10.1242/dev.112.1.161}, number={1}, journal={Development}, publisher={The Company of Biologists}, author={Xue, G. P. and Rivero, B. Pliego and Morris, R. J.}, year={1991}, month=may, pages={161–176} }

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    "1477-9129"
  ],
  "subject": [],
  "published": {
    "date-parts": [
      [
        1991,
        5,
        1
      ]
    ]
  }
}