DOI: 10.1242/dev.110.4.1241. An <i>in situ</i> assessment of the routes and extents of colonisation of the mouse embryo by embryonic stem cells and their descendants

An in situ assessment of the routes and extents of colonisation of the mouse embryo by embryonic stem cells and their descendants

10.1242/dev.110.4.1241

Crossref journal-article

The Company of Biologists

Development (237)

Abstract

Abstract An embryonic stem (ES) cell line stably expressing lacZ under the control of an endogenous promoter has been isolated and used as a marker to follow the fate of ES cells injected into blastocysts and morulae, before midgestation. The results show a multisite pattern of blastocyst colonization by ES cells deposited into the blastocoel cavity and a low degree of mingling between ES cells and ICM cells. Furthermore, analysis of dispersal of ES cell descendants in postimplantation chimaeric embryos showed that colonization can be highly variable from one region of the embryo to another. In contrast, a high and reproducible degree of chimaerism was obtained when the ES cells were injected at the morula stage prior to ICM formation.

Bibliography

Lallemand, Y., & BrÃ»let, P. (1990). An in situ assessment of the routes and extents of colonisation of the mouse embryo by embryonic stem cells and their descendants. Development, 110(4), 1241â1248.

Authors 2

Yvan Lallemand (first)
Philippe Brûlet (additional)

References 27 Referenced 44

10.1242/dev.106.1.37 / Development / An in situ transgenic enzyme marker for the midgestation mouse embryo and the visualization of inner cell mass clones during early organogenesis by Beddington (1989)
10.1242/dev.105.4.733 / Development / An assessment of the developmental potential of embryonic stem cells in the midgestation mouse embryo by Beddington (1989)
{'key': '2023050312051383500_DEVELOP_110_4_1241C3', 'first-page': '988', 'article-title': 'Efficient transformation and frequent single-site, singlecopy insertion of DNA can be obtained in mouse erythroleukemia cells transformed by electroporation', 'volume': '14', 'author': 'Boggs', 'year': '1986', 'journal-title': 'Exp. Hematol.'} / Exp. Hematol. / Efficient transformation and frequent single-site, singlecopy insertion of DNA can be obtained in mouse erythroleukemia cells transformed by electroporation by Boggs (1986)
{'key': '2023050312051383500_DEVELOP_110_4_1241C4', 'first-page': '113', 'article-title': 'Production and analysis of chimaeric mice', 'volume-title': 'Teratocarcinomas and Embryonic Stem Cells: a Practical Approach', 'author': 'Bradley', 'year': '1987'} / Teratocarcinomas and Embryonic Stem Cells: a Practical Approach / Production and analysis of chimaeric mice by Bradley (1987)
10.1038/309255a0 / Nature / Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines by Bradley (1984)
10.1093/nar/15.4.1353 / Nucl. Acids Res. / Comparison of the consensus sequence flanking translational start sites in Drosophila and vertebrates by Cavener (1987)
10.1093/nar/15.3.1311 / Nucl. Acids Res. / Electroporation for the efficient transfection of mammalian ceils with DNA by Chu (1987)
{'key': '2023050312051383500_DEVELOP_110_4_1241C8', 'first-page': '27', 'article-title': 'The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium', 'volume': '87', 'author': 'Doetschman', 'year': '1985', 'journal-title': 'J. Embryol. exp. Morph.'} / J. Embryol. exp. Morph. / The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium by Doetschman (1985)
10.1038/292154a0 / Nature, Lond. / Establishment in culture of pluripotential cells from mouse embryos by Evans (1981)
10.1016/0014-4827(89)90245-0 / Expl Cell Res. / Factors influencing the differentiation of embryonal carcinoma and embryo-derived stem cells by Fisher (1989)
10.1242/jcs.1988.Supplement_10.2 / J. Cell Sci. Suppl. / Multi-lineage ‘stem’ cells in the mammalian embryo by Gardner (1988)
10.1073/pnas.83.23.9065 / Proc. natn. Acad. Sci. U.S.A. / Transgenesis by means of blastocyst-derived embryonic stem cell lines by Gossler (1986)
10.1126/science.2497519 / Science / Mouse embryonic stem cells and reporter constructs to detect developmentally regulated genes by Gossler (1989)
10.1016/0092-8674(84)90472-0 / Cell / Two distinct enhancers with different cell specificities coexist in the regulatory region of polyoma by Herbomel (1984)
{'key': '2023050312051383500_DEVELOP_110_4_1241C15', 'volume-title': 'Manipulating the Mouse Embryo: a Laboratory Manual. (Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.)', 'author': 'Hogan', 'year': '1986'} / Manipulating the Mouse Embryo: a Laboratory Manual. (Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.) by Hogan (1986)
10.1073/pnas.86.22.8927 / Proc. natn. Acad. Sci. U.S.A. / Germ-line transmission of a planned alteration made in a hypoxanthine phosphoribosyltransferase gene by homologous recombination in embryonic stem cells by Koller (1989)
{'key': '2023050312051383500_DEVELOP_110_4_1241C17', 'article-title': 'Targeted replacement of the homeo-gene Hox-3.1 by the E. Coli β-galactosidase in mouse chimaeric embryos', 'volume-title': 'Proc. natn. Acad. Sci. U.S.A, (in press)', 'author': 'Le Mouellic', 'year': '1990'} / Proc. natn. Acad. Sci. U.S.A, (in press) / Targeted replacement of the homeo-gene Hox-3.1 by the E. Coli β-galactosidase in mouse chimaeric embryos by Le Mouellic (1990)
{'key': '2023050312051383500_DEVELOP_110_4_1241C18', 'first-page': '71', 'article-title': 'Embryo-derived stem cell lines', 'volume-title': 'Teratocarcinomas and Embryonic Stem Cells: a Practical Approach', 'author': 'Robertson', 'year': '1987'} / Teratocarcinomas and Embryonic Stem Cells: a Practical Approach / Embryo-derived stem cell lines by Robertson (1987)
10.1038/323445a0 / Nature, Lond. / Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector by Robertson (1986)
10.1016/0012-1606(79)90021-6 / Devi Biol. / The possible dual origin of the ectoderm of the chorion in the mouse embryo by Rossant (1979)
10.1126/science.2554496 / Science / Germ-line transmission of a c-abl mutation produced by targeted gene disruption in ES cells by Schwartzberg (1989)
{'key': '2023050312051383500_DEVELOP_110_4_1241C22', 'first-page': '289', 'article-title': 'Aggregation between teratocarcinoma cells and preimplantation mouse embryos', 'volume': '58', 'author': 'Stewart', 'year': '1980', 'journal-title': 'J. Embryol. exp. Morph.'} / J. Embryol. exp. Morph. / Aggregation between teratocarcinoma cells and preimplantation mouse embryos by Stewart (1980)
{'key': '2023050312051383500_DEVELOP_110_4_1241C23', 'first-page': '167', 'article-title': 'Formation of viable chimaeras by aggregation between teratocarcinomas and preimplantation mouse embryos', 'volume': '67', 'author': 'Stewart', 'year': '1982', 'journal-title': 'J. Embryol. exp. Morph.'} / J. Embryol. exp. Morph. / Formation of viable chimaeras by aggregation between teratocarcinomas and preimplantation mouse embryos by Stewart (1982)
10.1002/j.1460-2075.1985.tb04138.x / EMBO J. / Expression of foreign genes from retroviral vectors in mouse teratocarcinoma chimaeras by Stewart (1985)
10.1016/0922-3371(90)90120-L / Cell Differ. Dev. / A mouse embryonic stem cell line showing pluripotency of differentiation in early embryos and ubiquitous -galactosidase expression by Suemori (1990)
10.1016/0092-8674(89)90905-7 / Cell / Germ line transmission and expression of a corrected HPRT gene produced by gene targeting in embryonic stem cells by Thompson (1989)
10.1038/342435a0 / Nature, Lond. / Germ-line transmission of a /-microglobulin gene produced by homologous recombination in embryonic stem cells by Zijlstra (1989)

Dates

Type	When
Created	4 years, 4 months ago (April 25, 2021, 9:44 p.m.)
Deposited	2 years, 4 months ago (May 3, 2023, 8:21 a.m.)
Indexed	1 year, 1 month ago (Aug. 4, 2024, 12:32 a.m.)
Issued	34 years, 9 months ago (Dec. 1, 1990)
Published	34 years, 9 months ago (Dec. 1, 1990)
Published Online	34 years, 9 months ago (Dec. 1, 1990)
Published Print	34 years, 9 months ago (Dec. 1, 1990)

Funders 0

None

BibTeX

@article{Lallemand_1990, title={An in situ assessment of the routes and extents of colonisation of the mouse embryo by embryonic stem cells and their descendants}, volume={110}, ISSN={1477-9129}, url={http://dx.doi.org/10.1242/dev.110.4.1241}, DOI={10.1242/dev.110.4.1241}, number={4}, journal={Development}, publisher={The Company of Biologists}, author={Lallemand, Yvan and Brûlet, Philippe}, year={1990}, month=dec, pages={1241–1248} }

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    "date-parts": [
      [
        1990,
        12,
        1
      ]
    ]
  }
}