DOI: 10.1242/dev.110.4.1159. Expression of the murine homeobox-containing gene <i>Hox-2.3</i> suggests multiple time-dependent and tissue-specific roles during development

Expression of the murine homeobox-containing gene Hox-2.3 suggests multiple time-dependent and tissue-specific roles during development

10.1242/dev.110.4.1159

Crossref journal-article

The Company of Biologists

Development (237)

Abstract

Abstract This study reports the expression pattern of the murine homeobox-containing gene Hox-2.3 during development. Using in situ hybridization, we first detect Hox-2.3 transcripts in the allantois primordium at 7.5 days post coitum (p.c.). One day later transcripts are found in embryonic ectoderm and mesoderm. In 9.5- and 10.5-day embryos Hox-2.3 expression is observed in the central nervous system (CNS) from a rostral boundary in the upper spinal cord to the caudal end. Within this anteroposterior domain, Hox-2.3 expression is also found in the peripheral nervous system, in the mesoderm and in the hindgut epithelium. The rostral boundary in the mesoderm is located at the level of the 11th somite and thus shifted posteriorwards compared to the rostral boundary in the neural tube. During subsequent development, the initially broad expression pattern in the somitic, lateral plate and intermediate mesoderm becomes restricted to structures in the urogenital system. In adults, the spinal cord and the derivatives of the Wolffian and Müllerian ducts continue to express the gene at a high level. The described temporal and tissue-specific changes in expression of Hox-2.3 are suggestive of several levels of regulation as reported for Drosophila homeotic genes and argue for more than one role of the gene during development and in adults.

Bibliography

Vogels, R., De Graaff, W., & Deschamps, J. (1990). Expression of the murine homeobox-containing gene Hox-2.3 suggests multiple time-dependent and tissue-specific roles during development. Development, 110(4), 1159â1168.

Authors 3

Ronald Vogels (first)
Wim De Graaff (additional)
Jacqueline Deschamps (additional)

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Dates

Type	When
Created	4 years, 3 months ago (April 25, 2021, 9:44 p.m.)
Deposited	2 years, 3 months ago (May 3, 2023, 8:16 a.m.)
Indexed	11 months, 1 week ago (Sept. 12, 2024, 1:56 p.m.)
Issued	34 years, 8 months ago (Dec. 1, 1990)
Published	34 years, 8 months ago (Dec. 1, 1990)
Published Online	34 years, 8 months ago (Dec. 1, 1990)
Published Print	34 years, 8 months ago (Dec. 1, 1990)

Funders 0

None

BibTeX

@article{Vogels_1990, title={Expression of the murine homeobox-containing gene Hox-2.3 suggests multiple time-dependent and tissue-specific roles during development}, volume={110}, ISSN={1477-9129}, url={http://dx.doi.org/10.1242/dev.110.4.1159}, DOI={10.1242/dev.110.4.1159}, number={4}, journal={Development}, publisher={The Company of Biologists}, author={Vogels, Ronald and De Graaff, Wim and Deschamps, Jacqueline}, year={1990}, month=dec, pages={1159–1168} }

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