DOI: 10.1242/dev.110.3.733. Primary structure and embryonic expression pattern of the mouse <i>Hox-4.3</i>* homeobox gene

Primary structure and embryonic expression pattern of the mouse Hox-4.3* homeobox gene

10.1242/dev.110.3.733

Crossref journal-article

The Company of Biologists

Development (237)

Abstract

Abstract We report the cloning, genomic localization, primary structure and developmental expression pattern of the novel mouse Hox-4.3 gene. This gene is located within the HOX-4(5) complex, at a position which classifies it as a member of the Hox-3.1 and -2.4 subfamily, the DNA and predicted protein sequences further confirmed this classification. Hox-4.3 has a primary structure characteristic of a Hox gene but, in addition, contains several monotonic stretches of amino acids, one of the ‘paired’-like type. As expected from its presence and position within the complex, Hox-4.3 is developmentally expressed in structures of either mesodermal or neurecto-dermal origin located or derived from below a precise craniocaudal level. However, a very important offset between anteroposterior boundaries within neuroectoderm versus mesoderm derivatives is observed. Like other genes of the HOX-4(5) complex, Hox-4.3 is expressed in developing limbs and gonads, suggesting that ‘cluster specificity’ could be a feature of the HOX network.

Bibliography

IzpisÃ¹a-Belmonte, J.-C., DollÃ©, P., Renucci, A., Zappavigna, V., Falkenstein, H., & Duboule, D. (1990). Primary structure and embryonic expression pattern of the mouse Hox-4.3* homeobox gene. Development, 110(3), 733â745.

Authors 6

Juan-Carlos Izpisùa-Belmonte (first)
Pascal Dollé (additional)
Armand Renucci (additional)
Vincenzo Zappavigna (additional)
Hildegard Falkenstein (additional)
Denis Duboule (additional)

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Dates

Type	When
Created	4 years, 4 months ago (April 25, 2021, 9:38 p.m.)
Deposited	1 year, 1 month ago (July 10, 2024, 3:24 a.m.)
Indexed	1 year ago (Aug. 9, 2024, 1:53 p.m.)
Issued	34 years, 10 months ago (Nov. 1, 1990)
Published	34 years, 10 months ago (Nov. 1, 1990)
Published Online	34 years, 10 months ago (Nov. 1, 1990)
Published Print	34 years, 10 months ago (Nov. 1, 1990)

Funders 0

None

BibTeX

@article{Izpis_a_Belmonte_1990, title={Primary structure and embryonic expression pattern of the mouse Hox-4.3* homeobox gene}, volume={110}, ISSN={1477-9129}, url={http://dx.doi.org/10.1242/dev.110.3.733}, DOI={10.1242/dev.110.3.733}, number={3}, journal={Development}, publisher={The Company of Biologists}, author={Izpisùa-Belmonte, Juan-Carlos and Dollé, Pascal and Renucci, Armand and Zappavigna, Vincenzo and Falkenstein, Hildegard and Duboule, Denis}, year={1990}, month=nov, pages={733–745} }

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