DOI: 10.1242/dev.110.2.643. <i>Pax8</i>, a murine paired box gene expressed in the developing excretory system and thyroid gland

Pax8, a murine paired box gene expressed in the developing excretory system and thyroid gland

10.1242/dev.110.2.643

Crossref journal-article

The Company of Biologists

Development (237)

Abstract

ABSTRACTSeveral mouse genes designated ‘Pax genes’ contain a highly conserved DNA sequence homologous to the paired box of Drosophila. Here we describe the isolation of Pax8, a novel paired box containing clone from an 8.5 day p.c. mouse embryo cDNA library. An open reading frame of 457 amino acids (aa) contains the 128 aa paired domain near the amino terminus. Another conserved region present in some other paired box genes, the octapeptide Tyr-Ser-Ile-Asn-Gly-Leu-Leu-Gly, is located 43 aa C-terminal to the paired domain. Using an interspecies backcross system, we have mapped the Pax8 gene within the proximal portion of mouse chromosome 2 in a close linkage to the surf locus. Several developmental mutations are located in this region. In situ hybridization was used to determine the pattern of Pax8 expression during mouse embryogenesis. Pax8 is expressed transiently between 11.5 and 12.5 days of gestation along the rostrocaudal axis extending from the myelencephalon throughout the length of the neural tube, predominantly in two parallel regions on either side of the basal plate. We also detected Pax8 expression in the developing thyroid gland beginning at 10.5 days of gestation, during the thyroid evagination. In the mesonephros and metanephros the expression of Pax8 was localized to the mesenchymal condensations, which are induced by the nephric duct and ureter, respectively. These condensations develop to functional units, the nephrons, of the kidney. These data are consistent with a role for Pax8 in the induction of kidney epithelium. The embryonic expression pattern of Pax8 is compared with that of Pax2, another recently described paired box gene expressed in the developing excretory system.

Bibliography

Plachov, D., Chowdhury, K., Walther, C., Simon, D., Guenet, J.-L., & Gruss, P. (1990). Pax8, a murine paired box gene expressed in the developing excretory system and thyroid gland. Development, 110(2), 643â651.

Authors 6

Dimitrij Plachov (first)
Kamal Chowdhury (additional)
Claudia Walther (additional)
Dominique Simon (additional)
Jean-Louis Guenet (additional)
Peter Gruss (additional)

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Dates

Type	When
Created	4 years, 4 months ago (April 25, 2021, 9:44 p.m.)
Deposited	1 year ago (Aug. 29, 2024, 6:50 a.m.)
Indexed	1 week, 2 days ago (Aug. 23, 2025, 1:22 a.m.)
Issued	34 years, 11 months ago (Oct. 1, 1990)
Published	34 years, 11 months ago (Oct. 1, 1990)
Published Online	34 years, 11 months ago (Oct. 1, 1990)
Published Print	34 years, 11 months ago (Oct. 1, 1990)

Funders 0

None

BibTeX

@article{Plachov_1990, title={Pax8, a murine paired box gene expressed in the developing excretory system and thyroid gland}, volume={110}, ISSN={1477-9129}, url={http://dx.doi.org/10.1242/dev.110.2.643}, DOI={10.1242/dev.110.2.643}, number={2}, journal={Development}, publisher={The Company of Biologists}, author={Plachov, Dimitrij and Chowdhury, Kamal and Walther, Claudia and Simon, Dominique and Guenet, Jean-Louis and Gruss, Peter}, year={1990}, month=oct, pages={643–651} }

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  "abstract": "<jats:title>ABSTRACT</jats:title><jats:p>Several mouse genes designated \u2018Pax genes\u2019 contain a highly conserved DNA sequence homologous to the paired box of Drosophila. Here we describe the isolation of Pax8, a novel paired box containing clone from an 8.5 day p.c. mouse embryo cDNA library. An open reading frame of 457 amino acids (aa) contains the 128 aa paired domain near the amino terminus. Another conserved region present in some other paired box genes, the octapeptide Tyr-Ser-Ile-Asn-Gly-Leu-Leu-Gly, is located 43 aa C-terminal to the paired domain. Using an interspecies backcross system, we have mapped the Pax8 gene within the proximal portion of mouse chromosome 2 in a close linkage to the surf locus. Several developmental mutations are located in this region. In situ hybridization was used to determine the pattern of Pax8 expression during mouse embryogenesis. Pax8 is expressed transiently between 11.5 and 12.5 days of gestation along the rostrocaudal axis extending from the myelencephalon throughout the length of the neural tube, predominantly in two parallel regions on either side of the basal plate. We also detected Pax8 expression in the developing thyroid gland beginning at 10.5 days of gestation, during the thyroid evagination. In the mesonephros and metanephros the expression of Pax8 was localized to the mesenchymal condensations, which are induced by the nephric duct and ureter, respectively. These condensations develop to functional units, the nephrons, of the kidney. These data are consistent with a role for Pax8 in the induction of kidney epithelium. The embryonic expression pattern of Pax8 is compared with that of Pax2, another recently described paired box gene expressed in the developing excretory system.</jats:p>",
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