DOI: 10.1242/dev.110.2.609. In situ hybridization analysis of TGFβ3 RNA expression during mouse development: comparative studies with TGFβ1 and β2

In situ hybridization analysis of TGFβ3 RNA expression during mouse development: comparative studies with TGFβ1 and β2

10.1242/dev.110.2.609

Crossref journal-article

The Company of Biologists

Development (237)

Abstract

ABSTRACT To date, three closely-related TGFβ genes have been found in the mouse; TGFβ1, TGFβ2 and TGFβ3. Previous experiments have indicated that TGFβ1 and TGFβ2 may play important roles during mouse embryo-genesis. The present study now reports the distribution of transcripts of TGFβ3 in comparison to the other two genes and reveals overlapping but distinct patterns of RNA expression. TGFβ3 RNA is expressed in a diverse array of tissues including perichondrium, bone, intervertebral discs, mesenteries, pleura, heart, lung, palate, and amnion, as well as in central nervous system (CNS) structures such as the meninges, choroid plexus and the olfactory bulbs. Furthermore, in several organ systems, TGFβ3 transcripts are expressed during periods of active morphogenesis suggesting that the protein may be an important factor for the growth and differentiation of many embryonic tissues.

Bibliography

Pelton, R. W., Dickinson, M. E., Moses, H. L., & Hogan, B. L. M. (1990). In situ hybridization analysis of TGFÎ²3 RNA expression during mouse development: comparative studies with TGFÎ²1 and Î²2. Development, 110(2), 609â620.

Authors 4

Ron W. Pelton (first)
Mary E. Dickinson (additional)
Harold L. Moses (additional)
Brigid L. M. Hogan (additional)

References 35 Referenced 279

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Dates

Type	When
Created	4 years, 4 months ago (April 25, 2021, 9:44 p.m.)
Deposited	2 years, 3 months ago (May 3, 2023, 8:14 a.m.)
Indexed	1 month, 4 weeks ago (July 2, 2025, 2:48 p.m.)
Issued	34 years, 11 months ago (Oct. 1, 1990)
Published	34 years, 11 months ago (Oct. 1, 1990)
Published Online	34 years, 11 months ago (Oct. 1, 1990)
Published Print	34 years, 11 months ago (Oct. 1, 1990)

Funders 0

None

BibTeX

@article{Pelton_1990, title={In situ hybridization analysis of TGFβ3 RNA expression during mouse development: comparative studies with TGFβ1 and β2}, volume={110}, ISSN={1477-9129}, url={http://dx.doi.org/10.1242/dev.110.2.609}, DOI={10.1242/dev.110.2.609}, number={2}, journal={Development}, publisher={The Company of Biologists}, author={Pelton, Ron W. and Dickinson, Mary E. and Moses, Harold L. and Hogan, Brigid L. M.}, year={1990}, month=oct, pages={609–620} }

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  "abstract": "<jats:title>ABSTRACT</jats:title>\n               <jats:p>To date, three closely-related TGF\u03b2 genes have been found in the mouse; TGF\u03b21, TGF\u03b22 and TGF\u03b23. Previous experiments have indicated that TGF\u03b21 and TGF\u03b22 may play important roles during mouse embryo-genesis. The present study now reports the distribution of transcripts of TGF\u03b23 in comparison to the other two genes and reveals overlapping but distinct patterns of RNA expression. TGF\u03b23 RNA is expressed in a diverse array of tissues including perichondrium, bone, intervertebral discs, mesenteries, pleura, heart, lung, palate, and amnion, as well as in central nervous system (CNS) structures such as the meninges, choroid plexus and the olfactory bulbs. Furthermore, in several organ systems, TGF\u03b23 transcripts are expressed during periods of active morphogenesis suggesting that the protein may be an important factor for the growth and differentiation of many embryonic tissues.</jats:p>",
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