DOI: 10.1242/dev.110.1.291. Cell patterning in the <i>Drosophila</i> segment: spatial regulation of the segment polarity gene <i>patched</i>

Cell patterning in the Drosophila segment: spatial regulation of the segment polarity gene patched

10.1242/dev.110.1.291

Crossref journal-article

The Company of Biologists

Development (237)

Abstract

Abstract Intrasegmental patterning in the Drosophila embryo requires the activity of the segment polarity genes. The acquisition of positional information by cells during embryogenesis is reflected in the dynamic patterns of expression of several of these genes. In the case of patched, early ubiquitous expression is followed by its repression in the anterior portion of each parasegment; subsequently each broad band of expression splits into two narrow stripes. In this study we analyse the contribution of other segment polarity gene functions to the evolution of this pattern; we find that the first step in patched regulation is under the control of engrailed whereas the second requires the activity of both cubitus interruptusD and patched itself. Furthermore, the products of engrailed, wingless and hedgehog are essential for maintaining the normal pattern of expression of patched.

Bibliography

Hidalgo, A., & Ingham, P. (1990). Cell patterning in the Drosophila segment: spatial regulation of the segment polarity gene patched. Development, 110(1), 291â301.

Authors 2

Alicia Hidalgo (first)
Philip Ingham (additional)

References 35 Referenced 146

10.1242/dev.101.1.1 / Development / The molecular basis for metameric pattern in the Drosophila embryo by Akam (1987)
10.1002/j.1460-2075.1987.tb02429.x / EMBO J / Molecular cloning of wingless, a segment polarity gene in Drosophila: The spatial distribution of a transcript in embryos by Baker (1987)
10.1242/dev.103.2.289 / Development / Localization of transcripts from the wingless gene in whole Drosophila embryos by Baker (1988)
10.1101/gad.1.10.1247 / Genes and Dev / Structure of two genes at the gooseberry locus related to the paired gene and their spatial expression during Drosophila embryogenesis by Baumgartner (1987)
10.1002/j.1460-2075.1990.tb08276.x / EMBO J. / The proto-oncogene int-1 encodes a secreted protein associated with the extracellular matrix by Bradley (1990)
{'volume-title': 'The Embryonic Development of', 'year': '1985', 'author': 'Campos-Ortega', 'key': '2024121722200182100_DEVELOP_110_1_291C6'} / The Embryonic Development of by Campos-Ortega (1985)
10.1002/j.1460-2075.1987.tb02575.x / EMBO J. / The gooseberry-zipper region of Drosophila: five genes encode different spatially restricted transcripts in the embryo by Coté (1987)
{'key': '2024121722200182100_DEVELOP_110_1_291C8', 'article-title': 'Molecular and cellular interactions responsible for intrasegmental patterning during Drosophila embryogenesis', 'volume': '3', 'author': 'Dinardo', 'year': '1990', 'journal-title': 'Seminars in Cell Biology'} / Seminars in Cell Biology / Molecular and cellular interactions responsible for intrasegmental patterning during Drosophila embryogenesis by Dinardo (1990)
10.1016/0092-8674(85)90012-1 / Cell / Development of embryonic pattern in D. melanogaster as revealed by accumulation of the nuclear engrailed protein by Dinardo (1985)
10.1101/gad.1.10.1212 / Genes and Dev / Establishment and refinement of segmental pattern in the Drosophila embryo: spatial control of engrailed expression by pair-rule genes by Dinardo (1987)
10.1038/332604a0 / Nature / Two tiered regulation of spatially patterned engrailed gene expression during Drosophda embryogenesis by Dinardo (1988)
10.1038/313284a0 / Nature / Isolation of a homeobox containing gene from the engrailed region of Drosophila and the spatial distribution of its transcripts by Fjose (1985)
10.1016/0092-8674(89)90021-4 / Cell / The Drosophila patched gene encodes a putative membrane protein required for segmental patterning by Hooper (1989)
10.1016/0092-8674(86)90018-8 / Cell / Regulatory interactions between the segmentation genes fushi-tarazu, hairy, and engrailed in the Drosophila blastoderm by Howard (1986)
10.1038/335025a0 / Nature / The molecular genetics of embryonic pattern formation in Drosophila by Ingham (1988)
10.1038/331073a0 / Nature / Regulation of segment polarity genes in the Drosophila blastoderm by fushi-tarazu and even-skipped by Ingham (1988)
10.1038/318439a0 / Nature / Transcription pattern of the Drosophila segmentation gene hairy by Ingham (1985)
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10.1038/328440a0 / Nature / Borders of parasegments in Drosophila embryos are delimited by the fushi tarazu and even-skipped genes by Lawrence (1987)
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{'key': '2024121722200182100_DEVELOP_110_1_291C28', 'first-page': '2723', 'article-title': 'Secreted int-1 protein is associated with the cell surface', 'volume': '10', 'author': 'Papkoff', 'year': '1990', 'journal-title': 'Molec. cell. Biol'} / Molec. cell. Biol / Secreted int-1 protein is associated with the cell surface by Papkoff (1990)
{'key': '2024121722200182100_DEVELOP_110_1_291C29', 'article-title': 'The Drosophila segment polarity gene patched is involved in a position-signalling mechanism in imaginai discs', 'author': 'Phillips', 'year': '1990', 'journal-title': 'Development, in press'} / Development, in press / The Drosophila segment polarity gene patched is involved in a position-signalling mechanism in imaginai discs by Phillips (1990)
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Dates

Type	When
Created	4 years, 4 months ago (April 25, 2021, 9:52 p.m.)
Deposited	8 months, 2 weeks ago (Dec. 17, 2024, 5:20 p.m.)
Indexed	39 minutes ago (Sept. 2, 2025, 10:54 a.m.)
Issued	35 years ago (Sept. 1, 1990)
Published	35 years ago (Sept. 1, 1990)
Published Online	35 years ago (Sept. 1, 1990)
Published Print	35 years ago (Sept. 1, 1990)

Funders 0

None

BibTeX

@article{Hidalgo_1990, title={Cell patterning in the Drosophila segment: spatial regulation of the segment polarity gene patched}, volume={110}, ISSN={1477-9129}, url={http://dx.doi.org/10.1242/dev.110.1.291}, DOI={10.1242/dev.110.1.291}, number={1}, journal={Development}, publisher={The Company of Biologists}, author={Hidalgo, Alicia and Ingham, Philip}, year={1990}, month=sep, pages={291–301} }

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